Agressive fibromatosis involving the mandible--case report and review of the literature

László Seper; Horst Bürger; Josef Vormoor; Ulrich Joos; Johannes Kleinheinz

doi:10.1016/j.tripleo.2004.03.026

Agressive fibromatosis involving the mandible--case report and review of the literature

László Seper, Horst Bürger, Josef Vormoor, Ulrich Joos, Johannes Kleinheinz

Research output: Contribution to journal › Review article › peer-review

Abstract

BACKGROUND: Aggressive fibromatosis (AF) involving the mandible is rare, and surgery is often complicated by a high recurrence rate.

CASE REPORT: A 4-year-old boy was referred because of a fast growing painless mass which involved the entire left angle of the mandible. Excisional biopsy revealed AF, and local excision of the tumor was performed. Six months after surgery a recurrence was detected. The tumor was determined to be unresectable and the boy was treated with low-dose chemotherapy including methotrexate and vinblastine for 1 year. With combined chemotherapy and surgical debulking, mutilating surgical resection will be delayed as long as possible or until completion of facial growth.

CONCLUSION: According to the literature, surgery is the most common treatment of AF in the head and neck region. However, particularly in children, alternative modes of therapy must be considered because of the high recurrence rate and to avoid mutilating operations.

Original language	English
Pages (from-to)	30-8
Number of pages	9
Journal	Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics
Volume	99
Issue number	1
DOIs	https://doi.org/10.1016/j.tripleo.2004.03.026
Publication status	Published - Jan 2005
Externally published	Yes

Keywords

Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Child, Preschool
Diagnosis, Differential
Fibromatosis, Aggressive/pathology
Follow-Up Studies
Humans
Male
Mandibular Neoplasms/pathology
Neoplasm Recurrence, Local/pathology

Access to Document

10.1016/j.tripleo.2004.03.026

Cite this

@article{ae0489dccda448188cb0efe45ad661fd,

title = "Agressive fibromatosis involving the mandible--case report and review of the literature",

abstract = "BACKGROUND: Aggressive fibromatosis (AF) involving the mandible is rare, and surgery is often complicated by a high recurrence rate.CASE REPORT: A 4-year-old boy was referred because of a fast growing painless mass which involved the entire left angle of the mandible. Excisional biopsy revealed AF, and local excision of the tumor was performed. Six months after surgery a recurrence was detected. The tumor was determined to be unresectable and the boy was treated with low-dose chemotherapy including methotrexate and vinblastine for 1 year. With combined chemotherapy and surgical debulking, mutilating surgical resection will be delayed as long as possible or until completion of facial growth.CONCLUSION: According to the literature, surgery is the most common treatment of AF in the head and neck region. However, particularly in children, alternative modes of therapy must be considered because of the high recurrence rate and to avoid mutilating operations.",

keywords = "Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Child, Preschool, Diagnosis, Differential, Fibromatosis, Aggressive/pathology, Follow-Up Studies, Humans, Male, Mandibular Neoplasms/pathology, Neoplasm Recurrence, Local/pathology",

author = "L{\'a}szl{\'o} Seper and Horst B{\"u}rger and Josef Vormoor and Ulrich Joos and Johannes Kleinheinz",

year = "2005",

month = jan,

doi = "10.1016/j.tripleo.2004.03.026",

language = "English",

volume = "99",

pages = "30--8",

journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics",

issn = "1079-2104",

publisher = "Mosby Inc.",

number = "1",

}

TY - JOUR

T1 - Agressive fibromatosis involving the mandible--case report and review of the literature

AU - Seper, László

AU - Bürger, Horst

AU - Vormoor, Josef

AU - Joos, Ulrich

AU - Kleinheinz, Johannes

PY - 2005/1

Y1 - 2005/1

N2 - BACKGROUND: Aggressive fibromatosis (AF) involving the mandible is rare, and surgery is often complicated by a high recurrence rate.CASE REPORT: A 4-year-old boy was referred because of a fast growing painless mass which involved the entire left angle of the mandible. Excisional biopsy revealed AF, and local excision of the tumor was performed. Six months after surgery a recurrence was detected. The tumor was determined to be unresectable and the boy was treated with low-dose chemotherapy including methotrexate and vinblastine for 1 year. With combined chemotherapy and surgical debulking, mutilating surgical resection will be delayed as long as possible or until completion of facial growth.CONCLUSION: According to the literature, surgery is the most common treatment of AF in the head and neck region. However, particularly in children, alternative modes of therapy must be considered because of the high recurrence rate and to avoid mutilating operations.

AB - BACKGROUND: Aggressive fibromatosis (AF) involving the mandible is rare, and surgery is often complicated by a high recurrence rate.CASE REPORT: A 4-year-old boy was referred because of a fast growing painless mass which involved the entire left angle of the mandible. Excisional biopsy revealed AF, and local excision of the tumor was performed. Six months after surgery a recurrence was detected. The tumor was determined to be unresectable and the boy was treated with low-dose chemotherapy including methotrexate and vinblastine for 1 year. With combined chemotherapy and surgical debulking, mutilating surgical resection will be delayed as long as possible or until completion of facial growth.CONCLUSION: According to the literature, surgery is the most common treatment of AF in the head and neck region. However, particularly in children, alternative modes of therapy must be considered because of the high recurrence rate and to avoid mutilating operations.

KW - Antineoplastic Combined Chemotherapy Protocols/therapeutic use

KW - Child, Preschool

KW - Diagnosis, Differential

KW - Fibromatosis, Aggressive/pathology

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Mandibular Neoplasms/pathology

KW - Neoplasm Recurrence, Local/pathology

U2 - 10.1016/j.tripleo.2004.03.026

DO - 10.1016/j.tripleo.2004.03.026

M3 - Review article

C2 - 15599346

SN - 1079-2104

VL - 99

SP - 30

EP - 38

JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics

JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics

IS - 1

ER -

Agressive fibromatosis involving the mandible--case report and review of the literature

Abstract

Keywords

Access to Document

Fingerprint

Cite this