TY - JOUR
T1 - Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats
AU - Baliu-Piqué, Mariona
AU - Kurniawan, Henry
AU - Ravesloot, Lars
AU - Verheij, Myrddin W.
AU - Drylewicz, Julia
AU - Lievaart-Peterson, Karianne
AU - Borghans, José A.M.
AU - Koets, Ad
AU - Tesselaar, Kiki
N1 - Funding Information:
The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007–2013) through the Marie-Curie Action “Quantitative T cell Immunology” Initial Training Network, with reference number FP7-PEOPLE-2012-ITN 317040-QuanTI, and the Dutch Ministry of Agriculture, Nature and Food Quality (WOT-01-002-002.02) and the Dutch Public – Private Partnership Small Ruminants program (Paratuberculosis in dairy goat husbandry).
Funding Information:
The research leading to these results has received funding from the European Union Seventh Framework Programme ( FP7/2007–2013 ) through the Marie-Curie Action “Quantitative T cell Immunology” Initial Training Network, with reference number FP7-PEOPLE-2012-ITN 317040 -QuanTI, and the Dutch Ministry of Agriculture, Nature and Food Quality ( WOT-01-002-002.02 ) and the Dutch Public – Private Partnership Small Ruminants program (Paratuberculosis in dairy goat husbandry).
Publisher Copyright:
© 2018
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Neonatal mammals have increased disease susceptibility and sub-optimal vaccine responses. This raises problems in both humans and farm animals. The high prevalence of paratuberculosis in goats and the lack of an effective vaccine against it have a strong impact on the dairy sector, and calls for vaccines optimized for the neonatal immune system. We characterized the composition of the T-cell pool in neonatal kids and adult goats and quantified their turnover rates using in vivo deuterium labelling. From birth to adulthood, CD4+ T-cells were the predominant subset in the thymus and lymph nodes, while spleen and bone marrow contained mainly CD8+ lymphocytes. In blood, CD4+ T-cells were the predominant subset during the neonatal period, while CD8+ T-cells predominated in adults. We observed that thymic mass and cellularity increased during the first 5 months after birth, but decreased later in life. Deuterium labelling revealed that T-cell turnover rates in neonatal kids are considerably higher than in adult animals.
AB - Neonatal mammals have increased disease susceptibility and sub-optimal vaccine responses. This raises problems in both humans and farm animals. The high prevalence of paratuberculosis in goats and the lack of an effective vaccine against it have a strong impact on the dairy sector, and calls for vaccines optimized for the neonatal immune system. We characterized the composition of the T-cell pool in neonatal kids and adult goats and quantified their turnover rates using in vivo deuterium labelling. From birth to adulthood, CD4+ T-cells were the predominant subset in the thymus and lymph nodes, while spleen and bone marrow contained mainly CD8+ lymphocytes. In blood, CD4+ T-cells were the predominant subset during the neonatal period, while CD8+ T-cells predominated in adults. We observed that thymic mass and cellularity increased during the first 5 months after birth, but decreased later in life. Deuterium labelling revealed that T-cell turnover rates in neonatal kids are considerably higher than in adult animals.
KW - Deuterium
KW - Development
KW - Goat
KW - Mathematical modelling
KW - Neonatal adaptive immunity
KW - Stable isotope labelling
KW - T-cell turnover
KW - T-lymphocytes
UR - https://www.scopus.com/pages/publications/85059321817
U2 - 10.1016/j.dci.2018.12.004
DO - 10.1016/j.dci.2018.12.004
M3 - Article
C2 - 30550777
AN - SCOPUS:85059321817
SN - 0145-305X
VL - 93
SP - 1
EP - 10
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
ER -