TY - JOUR
T1 - Age of platelet concentrates and time to the next transfusion
AU - Caram-Deelder, Camila
AU - van der Bom, Johanna G
AU - Putter, Hein
AU - Leyte, Anja
AU - van de Kerkhof, Daan
AU - Evers, Dorothea
AU - Beckers, Erik A M
AU - Weerkamp, Floor
AU - Hudig, Francisca
AU - Zwaginga, Jaap Jan
AU - Rondeel, Jan M.M.
AU - de Vooght, Karen M.K.
AU - Pe´que´riaux, Nathalie C.V.
AU - Visser, Otto J
AU - Wallis, Jonathan P.
AU - Middelburg, Rutger A.
N1 - Funding Information:
We thank Aad Pors (Sanquin Leiden) and Peter F. Kemper (Dutch transfusion data warehouse) for delivering the data. CCD designed research, performed research, collected data, analyzed and interpreted data, performed statistical analysis, and wrote the manuscript; JGvdB designed research, interpreted data, and revised the manuscript; HP analyzed the data; JW designed research and revised the manuscript; RAM designed research, interpreted data, and wrote and revised the manuscript; all other authors were involved in the hospitals' data collection and revised the manuscript. All authors had full access to the data and approved the submission.
Publisher Copyright:
© 2017 AABB
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - BACKGROUND: Storage time of platelet (PLT) concentrates has been negatively associated with clinical efficacy outcomes. The aim of this study was to quantify the association between storage time of PLT concentrates and interval to the next PLT transfusion for different types of PLT components, stored for up to 7 days and transfused to transfusion-dependent hematooncology patients with thrombocytopenia. STUDY DESIGN AND METHODS: From a cohort of patients from 10 major Dutch hospitals, patients were selected whose transfusion patterns were compatible with PLT transfusion dependency due to hematooncologic disease. Mean time to the next transfusion and mean differences in time to the next transfusion for different storage time categories (i.e., fresh, <4 days; intermediate, 4-5 days; and old, >5 days) were estimated, per component type, using multilevel mixed-effects linear models. RESULTS: Among a cohort of 29,761 patients who received 140,896 PLT transfusions we selected 4441 hematooncology patients who had received 12,724 PLT transfusions during periods of PLT transfusion dependency. Transfusion of fresh, compared to old, buffy coat–derived PLTs in plasma was associated with a delay to the next transfusion of 6.2 hours (95% confidence interval [CI], 4.5-8.0 hr). For buffy coat–derived PLTs in PAS-B and -C this difference was 7.7 hours (95% CI, 2.2-13.3 hr) and 3.9 hours (95% CI, –2.1 to 9.9 hr) while for apheresis PLTs in plasma it was only 1.8 hours (95% CI, –3.5 to 7.1 hr). CONCLUSION: Our results indicate that the time to the next transfusion shortens with increasing age of transfused buffy coat–derived PLT concentrates. This association was not observed for apheresis PLTs.
AB - BACKGROUND: Storage time of platelet (PLT) concentrates has been negatively associated with clinical efficacy outcomes. The aim of this study was to quantify the association between storage time of PLT concentrates and interval to the next PLT transfusion for different types of PLT components, stored for up to 7 days and transfused to transfusion-dependent hematooncology patients with thrombocytopenia. STUDY DESIGN AND METHODS: From a cohort of patients from 10 major Dutch hospitals, patients were selected whose transfusion patterns were compatible with PLT transfusion dependency due to hematooncologic disease. Mean time to the next transfusion and mean differences in time to the next transfusion for different storage time categories (i.e., fresh, <4 days; intermediate, 4-5 days; and old, >5 days) were estimated, per component type, using multilevel mixed-effects linear models. RESULTS: Among a cohort of 29,761 patients who received 140,896 PLT transfusions we selected 4441 hematooncology patients who had received 12,724 PLT transfusions during periods of PLT transfusion dependency. Transfusion of fresh, compared to old, buffy coat–derived PLTs in plasma was associated with a delay to the next transfusion of 6.2 hours (95% confidence interval [CI], 4.5-8.0 hr). For buffy coat–derived PLTs in PAS-B and -C this difference was 7.7 hours (95% CI, 2.2-13.3 hr) and 3.9 hours (95% CI, –2.1 to 9.9 hr) while for apheresis PLTs in plasma it was only 1.8 hours (95% CI, –3.5 to 7.1 hr). CONCLUSION: Our results indicate that the time to the next transfusion shortens with increasing age of transfused buffy coat–derived PLT concentrates. This association was not observed for apheresis PLTs.
KW - Journal Article
UR - https://www.scopus.com/pages/publications/85032832819
U2 - 10.1111/trf.14388
DO - 10.1111/trf.14388
M3 - Article
AN - SCOPUS:85032832819
SN - 0041-1132
VL - 58
SP - 121
EP - 131
JO - Transfusion
JF - Transfusion
IS - 1
ER -