Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study

Jenny Chang-Claude; Nadine Andrieu; Matti Rookus; Richard Brohet; Antonis C. Antoniou; Susan Peock; Rosemarie Davidson; Louise Izatt; Trevor Cole; Catherine Noguès; Elisabeth Luporsi; Laetitia Huiart; Nicoline Hoogerbrugge; Flora E. Van Leeuwen; Ana Osorio; Jorunn Eyfjord; Paolo Radice; David E. Goldgar; Douglas F. Easton; Teresa Wagner; Verena Korn; Anne Marie Gerdes; Edith Olah; Jorunn Eyford; Siranonoush Manoukian; Marco A. Pierotti; Javier Benitez; Trinidad Caldes; Miguel De La Hoya; Jan Lubinski; Brita Arver; H. Olsson; Niklas Loman; Jacques Simard; Catherine Sibille; Christi Van Asperen; Hanne Meijers-Heijboer; Senno Verhoef; Hans Vasen; Margreet Ausems; Fred Menko; Encarna Gomez-Garcia; Margaret Cook; Cassandra Engel; Neva Haites; Helen Gregory; Patrick Morrison; Carole McKeown; Alan Donaldson; Joan Paterson; Jonathan Gray; Peter Daly; David Barton; Mary Porteus; Michael Steel; Carole Brewer; Julia Rankin; Victoria Murday; Gabriella Pichert; Huw Dorkins; Richard Trembath; Tim Bishop; Carol Chu; Ian Ellis; Gareth Evans; Fiona Lalloo; Andrew Shenton; James Mackay; Anne Robinson; Susan Ritchie; Fiona Douglas; John Burn; Sarah Durell; Lucy Side; Ros Eeles; Jackie Cook; Oliver Quarrell; Shirley Hodgson; Diana Eccles; Anneke Lucassen; Emmanuelle Fourme; Rosette Lidereau; Denise Stevens; Dominique Stoppa-Lyonnet; Marion Gauthier-Villars; Agnès Chompret; Jean Pierre Fricker; Christine Lasset; Valérie Bonadona; Pascaline Berthet; Hagay Sobol; François Eisinger; Laurence Gladieff; Rosine Guimbaud; Alain Lortholary; Marc Frénay; Laurence Faivre; Michel Longy; Tan Dat Nguyen; Paul Gesta; Philippe Vennin; Claude Adenis; Annie Chevrier; Annick Rossi; Yves Jean Bignon; Jean Marc Limacher; Catherine Dugast; Liliane Demange; Hélène Zattara-Cannoni; Hélène Dreyfus; Mehrdad Noruzinia; Laurence Venat-Bouvet; Catherine Bonaïti; Claire Julian-Reynier; Florent De Vathaire

doi:10.1158/1055-9965.EPI-06-0829

Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study

Jenny Chang-Claude^*, Nadine Andrieu, Matti Rookus, Richard Brohet, Antonis C. Antoniou, Susan Peock, Rosemarie Davidson, Louise Izatt, Trevor Cole, Catherine Noguès, Elisabeth Luporsi, Laetitia Huiart, Nicoline Hoogerbrugge, Flora E. Van Leeuwen, Ana Osorio, Jorunn Eyfjord, Paolo Radice, David E. Goldgar, Douglas F. Easton, Teresa WagnerVerena Korn, Anne Marie Gerdes, Edith Olah, Jorunn Eyford, Siranonoush Manoukian, Marco A. Pierotti, Javier Benitez, Trinidad Caldes, Miguel De La Hoya, Jan Lubinski, Brita Arver, H. Olsson, Niklas Loman, Jacques Simard, Catherine Sibille, Christi Van Asperen, Hanne Meijers-Heijboer, Senno Verhoef, Hans Vasen, Margreet Ausems, Fred Menko, Encarna Gomez-Garcia, Margaret Cook, Cassandra Engel, Neva Haites, Helen Gregory, Patrick Morrison, Carole McKeown, Alan Donaldson, Joan Paterson, Jonathan Gray, Peter Daly, David Barton, Mary Porteus, Michael Steel, Carole Brewer, Julia Rankin, Victoria Murday, Gabriella Pichert, Huw Dorkins, Richard Trembath, Tim Bishop, Carol Chu, Ian Ellis, Gareth Evans, Fiona Lalloo, Andrew Shenton, James Mackay, Anne Robinson, Susan Ritchie, Fiona Douglas, John Burn, Sarah Durell, Lucy Side, Ros Eeles, Jackie Cook, Oliver Quarrell, Shirley Hodgson, Diana Eccles, Anneke Lucassen, Emmanuelle Fourme, Rosette Lidereau, Denise Stevens, Dominique Stoppa-Lyonnet, Marion Gauthier-Villars, Agnès Chompret, Jean Pierre Fricker, Christine Lasset, Valérie Bonadona, Pascaline Berthet, Hagay Sobol, François Eisinger, Laurence Gladieff, Rosine Guimbaud, Alain Lortholary, Marc Frénay, Laurence Faivre, Michel Longy, Tan Dat Nguyen, Paul Gesta, Philippe Vennin, Claude Adenis, Annie Chevrier, Annick Rossi, Yves Jean Bignon, Jean Marc Limacher, Catherine Dugast, Liliane Demange, Hélène Zattara-Cannoni, Hélène Dreyfus, Mehrdad Noruzinia, Laurence Venat-Bouvet, Catherine Bonaïti, Claire Julian-Reynier, Florent De Vathaire

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

51 Citations (Scopus)

Abstract

Background: Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown. Methods: We assessed breast cancer risk in a large series of 1,187 BRCA1 and 414 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study. Rate ratios were estimated using a weighted Cox-regression approach. Results: Breast cancer risk was not significantly related to age at menopause {hazard ratio [HR] for menopause below age 35 years, 0.60 [95% confidence interval (95% CI), 0.25-1.44]; 35 to 40 years, 1.15 [0.65-2.04]; 45 to 54 years, 1.02 [0.65-1.60]; ≥55 years, 1.12 [0.12-5.02], as compared with premenopausal women}. However, there was some suggestion of a reduction in risk after menopause in BRCA2 carriers. There was some evidence of a protective effect of oophorectomy (HR, 0.56; 95% CI, 0.29-1.09) and a significant trend of decreasing risk with increasing time since oophorectomy, but no apparent effect of natural menopause. There was no association between age at menarche and breast cancer risk, nor any apparent association with the estimated total duration of breast mitotic activity. Conclusions: These results are consistent with other observations suggesting a protective effect of oophorectomy, similar in relative effect to that in the general population. The absence of an effect of age at natural menopause is, however, not consistent with findings in the general population and may reflect the different natural history of the disease in carriers.

Original language	English
Pages (from-to)	740-746
Number of pages	7
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	16
Issue number	4
DOIs	https://doi.org/10.1158/1055-9965.EPI-06-0829
Publication status	Published - 1 Apr 2007

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Chang-Claude, J., Andrieu, N., Rookus, M., Brohet, R., Antoniou, A. C., Peock, S., Davidson, R., Izatt, L., Cole, T., Noguès, C., Luporsi, E., Huiart, L., Hoogerbrugge, N., Van Leeuwen, F. E., Osorio, A., Eyfjord, J., Radice, P., Goldgar, D. E., Easton, D. F., ... De Vathaire, F. (2007). Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study. Cancer Epidemiology Biomarkers and Prevention, 16(4), 740-746. https://doi.org/10.1158/1055-9965.EPI-06-0829

@article{9818d0a7e6674b10a19118ba0dc99061,

title = "Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study",

abstract = "Background: Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown. Methods: We assessed breast cancer risk in a large series of 1,187 BRCA1 and 414 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study. Rate ratios were estimated using a weighted Cox-regression approach. Results: Breast cancer risk was not significantly related to age at menopause {hazard ratio [HR] for menopause below age 35 years, 0.60 [95% confidence interval (95% CI), 0.25-1.44]; 35 to 40 years, 1.15 [0.65-2.04]; 45 to 54 years, 1.02 [0.65-1.60]; ≥55 years, 1.12 [0.12-5.02], as compared with premenopausal women}. However, there was some suggestion of a reduction in risk after menopause in BRCA2 carriers. There was some evidence of a protective effect of oophorectomy (HR, 0.56; 95% CI, 0.29-1.09) and a significant trend of decreasing risk with increasing time since oophorectomy, but no apparent effect of natural menopause. There was no association between age at menarche and breast cancer risk, nor any apparent association with the estimated total duration of breast mitotic activity. Conclusions: These results are consistent with other observations suggesting a protective effect of oophorectomy, similar in relative effect to that in the general population. The absence of an effect of age at natural menopause is, however, not consistent with findings in the general population and may reflect the different natural history of the disease in carriers.",

author = "Jenny Chang-Claude and Nadine Andrieu and Matti Rookus and Richard Brohet and Antoniou, {Antonis C.} and Susan Peock and Rosemarie Davidson and Louise Izatt and Trevor Cole and Catherine Nogu{\`e}s and Elisabeth Luporsi and Laetitia Huiart and Nicoline Hoogerbrugge and {Van Leeuwen}, {Flora E.} and Ana Osorio and Jorunn Eyfjord and Paolo Radice and Goldgar, {David E.} and Easton, {Douglas F.} and Teresa Wagner and Verena Korn and Gerdes, {Anne Marie} and Edith Olah and Jorunn Eyford and Siranonoush Manoukian and Pierotti, {Marco A.} and Javier Benitez and Trinidad Caldes and {De La Hoya}, Miguel and Jan Lubinski and Brita Arver and H. Olsson and Niklas Loman and Jacques Simard and Catherine Sibille and {Van Asperen}, Christi and Hanne Meijers-Heijboer and Senno Verhoef and Hans Vasen and Margreet Ausems and Fred Menko and Encarna Gomez-Garcia and Margaret Cook and Cassandra Engel and Neva Haites and Helen Gregory and Patrick Morrison and Carole McKeown and Alan Donaldson and Joan Paterson and Jonathan Gray and Peter Daly and David Barton and Mary Porteus and Michael Steel and Carole Brewer and Julia Rankin and Victoria Murday and Gabriella Pichert and Huw Dorkins and Richard Trembath and Tim Bishop and Carol Chu and Ian Ellis and Gareth Evans and Fiona Lalloo and Andrew Shenton and James Mackay and Anne Robinson and Susan Ritchie and Fiona Douglas and John Burn and Sarah Durell and Lucy Side and Ros Eeles and Jackie Cook and Oliver Quarrell and Shirley Hodgson and Diana Eccles and Anneke Lucassen and Emmanuelle Fourme and Rosette Lidereau and Denise Stevens and Dominique Stoppa-Lyonnet and Marion Gauthier-Villars and Agn{\`e}s Chompret and Fricker, {Jean Pierre} and Christine Lasset and Val{\'e}rie Bonadona and Pascaline Berthet and Hagay Sobol and Fran{\c c}ois Eisinger and Laurence Gladieff and Rosine Guimbaud and Alain Lortholary and Marc Fr{\'e}nay and Laurence Faivre and Michel Longy and Nguyen, {Tan Dat} and Paul Gesta and Philippe Vennin and Claude Adenis and Annie Chevrier and Annick Rossi and Bignon, {Yves Jean} and Limacher, {Jean Marc} and Catherine Dugast and Liliane Demange and H{\'e}l{\`e}ne Zattara-Cannoni and H{\'e}l{\`e}ne Dreyfus and Mehrdad Noruzinia and Laurence Venat-Bouvet and Catherine Bona{\"i}ti and Claire Julian-Reynier and {De Vathaire}, Florent",

year = "2007",

month = apr,

day = "1",

doi = "10.1158/1055-9965.EPI-06-0829",

language = "English",

volume = "16",

pages = "740--746",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

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Chang-Claude, J, Andrieu, N, Rookus, M, Brohet, R, Antoniou, AC, Peock, S, Davidson, R, Izatt, L, Cole, T, Noguès, C, Luporsi, E, Huiart, L, Hoogerbrugge, N, Van Leeuwen, FE, Osorio, A, Eyfjord, J, Radice, P, Goldgar, DE, Easton, DF, Wagner, T, Korn, V, Gerdes, AM, Olah, E, Eyford, J, Manoukian, S, Pierotti, MA, Benitez, J, Caldes, T, De La Hoya, M, Lubinski, J, Arver, B, Olsson, H, Loman, N, Simard, J, Sibille, C, Van Asperen, C, Meijers-Heijboer, H, Verhoef, S, Vasen, H, Ausems, M, Menko, F, Gomez-Garcia, E, Cook, M, Engel, C, Haites, N, Gregory, H, Morrison, P, McKeown, C, Donaldson, A, Paterson, J, Gray, J, Daly, P, Barton, D, Porteus, M, Steel, M, Brewer, C, Rankin, J, Murday, V, Pichert, G, Dorkins, H, Trembath, R, Bishop, T, Chu, C, Ellis, I, Evans, G, Lalloo, F, Shenton, A, Mackay, J, Robinson, A, Ritchie, S, Douglas, F, Burn, J, Durell, S, Side, L, Eeles, R, Cook, J, Quarrell, O, Hodgson, S, Eccles, D, Lucassen, A, Fourme, E, Lidereau, R, Stevens, D, Stoppa-Lyonnet, D, Gauthier-Villars, M, Chompret, A, Fricker, JP, Lasset, C, Bonadona, V, Berthet, P, Sobol, H, Eisinger, F, Gladieff, L, Guimbaud, R, Lortholary, A, Frénay, M, Faivre, L, Longy, M, Nguyen, TD, Gesta, P, Vennin, P, Adenis, C, Chevrier, A, Rossi, A, Bignon, YJ, Limacher, JM, Dugast, C, Demange, L, Zattara-Cannoni, H, Dreyfus, H, Noruzinia, M, Venat-Bouvet, L, Bonaïti, C, Julian-Reynier, C & De Vathaire, F 2007, 'Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study', Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 4, pp. 740-746. https://doi.org/10.1158/1055-9965.EPI-06-0829

TY - JOUR

T1 - Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study

AU - Chang-Claude, Jenny

AU - Andrieu, Nadine

AU - Rookus, Matti

AU - Brohet, Richard

AU - Antoniou, Antonis C.

AU - Peock, Susan

AU - Davidson, Rosemarie

AU - Izatt, Louise

AU - Cole, Trevor

AU - Noguès, Catherine

AU - Luporsi, Elisabeth

AU - Huiart, Laetitia

AU - Hoogerbrugge, Nicoline

AU - Van Leeuwen, Flora E.

AU - Osorio, Ana

AU - Eyfjord, Jorunn

AU - Radice, Paolo

AU - Goldgar, David E.

AU - Easton, Douglas F.

AU - Wagner, Teresa

AU - Korn, Verena

AU - Gerdes, Anne Marie

AU - Olah, Edith

AU - Eyford, Jorunn

AU - Manoukian, Siranonoush

AU - Pierotti, Marco A.

AU - Benitez, Javier

AU - Caldes, Trinidad

AU - De La Hoya, Miguel

AU - Lubinski, Jan

AU - Arver, Brita

AU - Olsson, H.

AU - Loman, Niklas

AU - Simard, Jacques

AU - Sibille, Catherine

AU - Van Asperen, Christi

AU - Meijers-Heijboer, Hanne

AU - Verhoef, Senno

AU - Vasen, Hans

AU - Ausems, Margreet

AU - Menko, Fred

AU - Gomez-Garcia, Encarna

AU - Cook, Margaret

AU - Engel, Cassandra

AU - Haites, Neva

AU - Gregory, Helen

AU - Morrison, Patrick

AU - McKeown, Carole

AU - Donaldson, Alan

AU - Paterson, Joan

AU - Gray, Jonathan

AU - Daly, Peter

AU - Barton, David

AU - Porteus, Mary

AU - Steel, Michael

AU - Brewer, Carole

AU - Rankin, Julia

AU - Murday, Victoria

AU - Pichert, Gabriella

AU - Dorkins, Huw

AU - Trembath, Richard

AU - Bishop, Tim

AU - Chu, Carol

AU - Ellis, Ian

AU - Evans, Gareth

AU - Lalloo, Fiona

AU - Shenton, Andrew

AU - Mackay, James

AU - Robinson, Anne

AU - Ritchie, Susan

AU - Douglas, Fiona

AU - Burn, John

AU - Durell, Sarah

AU - Side, Lucy

AU - Eeles, Ros

AU - Cook, Jackie

AU - Quarrell, Oliver

AU - Hodgson, Shirley

AU - Eccles, Diana

AU - Lucassen, Anneke

AU - Fourme, Emmanuelle

AU - Lidereau, Rosette

AU - Stevens, Denise

AU - Stoppa-Lyonnet, Dominique

AU - Gauthier-Villars, Marion

AU - Chompret, Agnès

AU - Fricker, Jean Pierre

AU - Lasset, Christine

AU - Bonadona, Valérie

AU - Berthet, Pascaline

AU - Sobol, Hagay

AU - Eisinger, François

AU - Gladieff, Laurence

AU - Guimbaud, Rosine

AU - Lortholary, Alain

AU - Frénay, Marc

AU - Faivre, Laurence

AU - Longy, Michel

AU - Nguyen, Tan Dat

AU - Gesta, Paul

AU - Vennin, Philippe

AU - Adenis, Claude

AU - Chevrier, Annie

AU - Rossi, Annick

AU - Bignon, Yves Jean

AU - Limacher, Jean Marc

AU - Dugast, Catherine

AU - Demange, Liliane

AU - Zattara-Cannoni, Hélène

AU - Dreyfus, Hélène

AU - Noruzinia, Mehrdad

AU - Venat-Bouvet, Laurence

AU - Bonaïti, Catherine

AU - Julian-Reynier, Claire

AU - De Vathaire, Florent

PY - 2007/4/1

Y1 - 2007/4/1

N2 - Background: Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown. Methods: We assessed breast cancer risk in a large series of 1,187 BRCA1 and 414 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study. Rate ratios were estimated using a weighted Cox-regression approach. Results: Breast cancer risk was not significantly related to age at menopause {hazard ratio [HR] for menopause below age 35 years, 0.60 [95% confidence interval (95% CI), 0.25-1.44]; 35 to 40 years, 1.15 [0.65-2.04]; 45 to 54 years, 1.02 [0.65-1.60]; ≥55 years, 1.12 [0.12-5.02], as compared with premenopausal women}. However, there was some suggestion of a reduction in risk after menopause in BRCA2 carriers. There was some evidence of a protective effect of oophorectomy (HR, 0.56; 95% CI, 0.29-1.09) and a significant trend of decreasing risk with increasing time since oophorectomy, but no apparent effect of natural menopause. There was no association between age at menarche and breast cancer risk, nor any apparent association with the estimated total duration of breast mitotic activity. Conclusions: These results are consistent with other observations suggesting a protective effect of oophorectomy, similar in relative effect to that in the general population. The absence of an effect of age at natural menopause is, however, not consistent with findings in the general population and may reflect the different natural history of the disease in carriers.

AB - Background: Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown. Methods: We assessed breast cancer risk in a large series of 1,187 BRCA1 and 414 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study. Rate ratios were estimated using a weighted Cox-regression approach. Results: Breast cancer risk was not significantly related to age at menopause {hazard ratio [HR] for menopause below age 35 years, 0.60 [95% confidence interval (95% CI), 0.25-1.44]; 35 to 40 years, 1.15 [0.65-2.04]; 45 to 54 years, 1.02 [0.65-1.60]; ≥55 years, 1.12 [0.12-5.02], as compared with premenopausal women}. However, there was some suggestion of a reduction in risk after menopause in BRCA2 carriers. There was some evidence of a protective effect of oophorectomy (HR, 0.56; 95% CI, 0.29-1.09) and a significant trend of decreasing risk with increasing time since oophorectomy, but no apparent effect of natural menopause. There was no association between age at menarche and breast cancer risk, nor any apparent association with the estimated total duration of breast mitotic activity. Conclusions: These results are consistent with other observations suggesting a protective effect of oophorectomy, similar in relative effect to that in the general population. The absence of an effect of age at natural menopause is, however, not consistent with findings in the general population and may reflect the different natural history of the disease in carriers.

UR - http://www.scopus.com/inward/record.url?scp=34247504165&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-06-0829

DO - 10.1158/1055-9965.EPI-06-0829

M3 - Article

C2 - 17416765

AN - SCOPUS:34247504165

SN - 1055-9965

VL - 16

SP - 740

EP - 746

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

IS - 4

ER -

Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study

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