Afbeelden van amyloïdplaques in de hersenen met PET

Rik Ossenkoppele; Nelleke Tolboom; Yolande A Pijnenburg; Adriaan A Lammertsma; Philip Scheltens; Bart N M van Berckel

Afbeelden van amyloïdplaques in de hersenen met PET

Translated title of the contribution: Amyloid-plaque imaging of the brain using PET

Rik Ossenkoppele^*, Nelleke Tolboom, Yolande A Pijnenburg, Adriaan A Lammertsma, Philip Scheltens, Bart N M van Berckel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Alzheimer's disease (AD) is neuropathologically characterized by the presence of senile plaques. The formation of these plaques is caused by the accumulation of amyloid-beta protein (Aβ), a process that begins decades before the onset of the first clinical symptoms. Senile plaques can be visualized by using positron emission tomography (PET) and the tracer 11C-PIB. Such 'amyloid imaging' can contribute significantly to both early and differential diagnosis of Alzheimer's disease. In the future, amyloid imaging could also be useful for selecting patients for clinical trials and in evaluating the effects of disease modifying agents tailored at lowering Aβ burden.

Translated title of the contribution	Amyloid-plaque imaging of the brain using PET
Original language	Dutch
Article number	A2981
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	155
Publication status	Published - 2011
Externally published	Yes

Keywords

Alzheimer Disease/diagnostic imaging
Amyloid beta-Peptides/analysis
Brain/diagnostic imaging
Carbon Radioisotopes
Humans
Plaque, Amyloid/diagnostic imaging
Positron-Emission Tomography/methods

Cite this

@article{8acc0b1263d142fda9f0e12a20666d80,

title = "Afbeelden van amylo{\"i}dplaques in de hersenen met PET",

abstract = "Alzheimer's disease (AD) is neuropathologically characterized by the presence of senile plaques. The formation of these plaques is caused by the accumulation of amyloid-beta protein (Aβ), a process that begins decades before the onset of the first clinical symptoms. Senile plaques can be visualized by using positron emission tomography (PET) and the tracer 11C-PIB. Such 'amyloid imaging' can contribute significantly to both early and differential diagnosis of Alzheimer's disease. In the future, amyloid imaging could also be useful for selecting patients for clinical trials and in evaluating the effects of disease modifying agents tailored at lowering Aβ burden.",

keywords = "Alzheimer Disease/diagnostic imaging, Amyloid beta-Peptides/analysis, Brain/diagnostic imaging, Carbon Radioisotopes, Humans, Plaque, Amyloid/diagnostic imaging, Positron-Emission Tomography/methods",

author = "Rik Ossenkoppele and Nelleke Tolboom and Pijnenburg, {Yolande A} and Lammertsma, {Adriaan A} and Philip Scheltens and {van Berckel}, {Bart N M}",

year = "2011",

language = "Dutch",

volume = "155",

journal = "Nederlands Tijdschrift voor Geneeskunde",

issn = "0028-2162",

publisher = "Bohn Stafleu van Loghum",

}

TY - JOUR

T1 - Afbeelden van amyloïdplaques in de hersenen met PET

AU - Ossenkoppele, Rik

AU - Tolboom, Nelleke

AU - Pijnenburg, Yolande A

AU - Lammertsma, Adriaan A

AU - Scheltens, Philip

AU - van Berckel, Bart N M

PY - 2011

Y1 - 2011

N2 - Alzheimer's disease (AD) is neuropathologically characterized by the presence of senile plaques. The formation of these plaques is caused by the accumulation of amyloid-beta protein (Aβ), a process that begins decades before the onset of the first clinical symptoms. Senile plaques can be visualized by using positron emission tomography (PET) and the tracer 11C-PIB. Such 'amyloid imaging' can contribute significantly to both early and differential diagnosis of Alzheimer's disease. In the future, amyloid imaging could also be useful for selecting patients for clinical trials and in evaluating the effects of disease modifying agents tailored at lowering Aβ burden.

AB - Alzheimer's disease (AD) is neuropathologically characterized by the presence of senile plaques. The formation of these plaques is caused by the accumulation of amyloid-beta protein (Aβ), a process that begins decades before the onset of the first clinical symptoms. Senile plaques can be visualized by using positron emission tomography (PET) and the tracer 11C-PIB. Such 'amyloid imaging' can contribute significantly to both early and differential diagnosis of Alzheimer's disease. In the future, amyloid imaging could also be useful for selecting patients for clinical trials and in evaluating the effects of disease modifying agents tailored at lowering Aβ burden.

KW - Alzheimer Disease/diagnostic imaging

KW - Amyloid beta-Peptides/analysis

KW - Brain/diagnostic imaging

KW - Carbon Radioisotopes

KW - Humans

KW - Plaque, Amyloid/diagnostic imaging

KW - Positron-Emission Tomography/methods

M3 - Article

C2 - 21586182

SN - 0028-2162

VL - 155

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

M1 - A2981

ER -

Afbeelden van amyloïdplaques in de hersenen met PET

Abstract

Keywords

Fingerprint

Cite this