TY - JOUR
T1 - Adverse late health outcomes among children treated with 3D radiotherapy techniques
T2 - Study design of the Dutch pediatric 3D-RT study
AU - Beijer, Josien G.M.
AU - Kok, Judith L.
AU - Janssens, Geert O.
AU - Streefkerk, Nina
AU - de Vries, Andrica C.H.
AU - Slagter, Cleo
AU - Maduro, John H.
AU - Kroon, Petra S.
AU - Grootenhuis, Martha A.
AU - van Dulmen-den Broeder, Eline
AU - Loonen, Jacqueline J.
AU - Wendling, Markus
AU - Tissing, Wim J.E.
AU - van der Pal, Helena J.
AU - Louwerens, Marloes
AU - Bel, Arjan
AU - den Hartogh, Jaap
AU - van der Heiden-van der Loo, Margriet
AU - Kremer, Leontien C.M.
AU - Teepen, Jop C.
AU - Ronckers, Cécile M.
N1 - Funding Information:
C. Ronckers, Ph.D., reported a personal grant from the Dutch Cancer Society (grant no: UVA2012‐5517). J. Beijer reported a grant from the Dutch Cancer Society (grant no: UVA2015‐7655). The other authors reported no conflicts of interest and did not receive funding.
Funding Information:
We thank our colleagues in the departments of pediatric oncology and radiation oncology who assist(ed) in patient identification and data collection in the participating institutions. We thank the Trail and Data Center LATER and our colleagues who generously shared their expertise and advice in the study preparation phase. We are indebted to Aslihan Mantici, Luca Wams and Inge Niehoff for their meticulous efforts to maximize data completion and accuracy.
Publisher Copyright:
© 2023 The Authors. Cancer Reports published by Wiley Periodicals LLC.
PY - 2023/2
Y1 - 2023/2
N2 - Background: Adverse late health outcomes after multimodal treatment for pediatric cancer are diverse and of prime interest. Currently available evidence and survivorship care guidelines are largely based on studies addressing side-effects of two dimensional planned radiotherapy. Aims: The Dutch pediatric 3D-planned radiotherapy (3D-RT) study aims to gain insight in the long-term health outcomes among children who had radiotherapy in the 3D era. Here, we describe the study design, data-collection methods, and baseline cohort characteristics. Methods and Results: The 3D-RT study represents an expansion of the Dutch Childhood Cancer Survivor study (DCCSS) LATER cohort, including pediatric cancer patients diagnosed during 2000–2012, who survived at least 5 years after initial diagnosis and 2 years post external beam radiotherapy. Individual cancer treatment parameters were obtained from medical files. A national infrastructure for uniform collection and archival of digital radiotherapy files (Computed Tomography [CT]-scans, delineations, plan, and dose files) was established. Health outcome information, including subsequent tumors, originated from medical records at the LATER outpatient clinics, and national registry-linkage. With a median follow-up of 10.9 (interquartile range [IQR]: 7.9–14.3) years after childhood cancer diagnosis, 711 eligible survivors were identified. The most common cancer types were Hodgkin lymphoma, medulloblastoma, and nephroblastoma. Most survivors received radiotherapy directed to the head/cranium only, the craniospinal axis, or the abdominopelvic region. Conclusion: The 3D-RT study will provide knowledge on the risk of adverse late health outcomes and radiation-associated dose-effect relationships. This information is valuable to guide follow-up care of childhood cancer survivors and to refine future treatment protocols.
AB - Background: Adverse late health outcomes after multimodal treatment for pediatric cancer are diverse and of prime interest. Currently available evidence and survivorship care guidelines are largely based on studies addressing side-effects of two dimensional planned radiotherapy. Aims: The Dutch pediatric 3D-planned radiotherapy (3D-RT) study aims to gain insight in the long-term health outcomes among children who had radiotherapy in the 3D era. Here, we describe the study design, data-collection methods, and baseline cohort characteristics. Methods and Results: The 3D-RT study represents an expansion of the Dutch Childhood Cancer Survivor study (DCCSS) LATER cohort, including pediatric cancer patients diagnosed during 2000–2012, who survived at least 5 years after initial diagnosis and 2 years post external beam radiotherapy. Individual cancer treatment parameters were obtained from medical files. A national infrastructure for uniform collection and archival of digital radiotherapy files (Computed Tomography [CT]-scans, delineations, plan, and dose files) was established. Health outcome information, including subsequent tumors, originated from medical records at the LATER outpatient clinics, and national registry-linkage. With a median follow-up of 10.9 (interquartile range [IQR]: 7.9–14.3) years after childhood cancer diagnosis, 711 eligible survivors were identified. The most common cancer types were Hodgkin lymphoma, medulloblastoma, and nephroblastoma. Most survivors received radiotherapy directed to the head/cranium only, the craniospinal axis, or the abdominopelvic region. Conclusion: The 3D-RT study will provide knowledge on the risk of adverse late health outcomes and radiation-associated dose-effect relationships. This information is valuable to guide follow-up care of childhood cancer survivors and to refine future treatment protocols.
KW - childhood cancer survivors
KW - pediatric radiotherapy
KW - radiation dose effects
KW - side effects
KW - study design
UR - https://www.scopus.com/pages/publications/85147269339
U2 - 10.1002/cnr2.1620
DO - 10.1002/cnr2.1620
M3 - Article
C2 - 36715495
AN - SCOPUS:85147269339
SN - 2573-8348
VL - 6
JO - Cancer Reports
JF - Cancer Reports
IS - 2
M1 - e1620
ER -