Advancing lung organoids for COVID-19 research

Jelte van der Vaart; Mart M. Lamers; Bart L. Haagmans; Hans Clevers

doi:10.1242/dmm.049060

Advancing lung organoids for COVID-19 research

Jelte van der Vaart, Mart M. Lamers, Bart L. Haagmans, Hans Clevers^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

The COVID-19 pandemic has emphasised the need to develop effective treatments to combat emerging viruses. Model systems that poorly represent a virus’ cellular environment, however, may impede research and waste resources. Collaborations between cell biologists and virologists have led to the rapid development of representative organoid model systems to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We believe that lung organoids, in particular, have advanced our understanding of SARS-CoV-2 pathogenesis, and have laid a foundation to study future pandemic viruses and develop effective treatments.

Original language	English
Article number	dmm049060
Pages (from-to)	1-6
Journal	DMM Disease Models and Mechanisms
Volume	14
Issue number	6
DOIs	https://doi.org/10.1242/dmm.049060
Publication status	Published - Jun 2021

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10.1242/dmm.049060Licence: CC BY

dmm049060Final published version, 4.1 MBLicence: CC BY

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title = "Advancing lung organoids for COVID-19 research",

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AB - The COVID-19 pandemic has emphasised the need to develop effective treatments to combat emerging viruses. Model systems that poorly represent a virus’ cellular environment, however, may impede research and waste resources. Collaborations between cell biologists and virologists have led to the rapid development of representative organoid model systems to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We believe that lung organoids, in particular, have advanced our understanding of SARS-CoV-2 pathogenesis, and have laid a foundation to study future pandemic viruses and develop effective treatments.

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Advancing lung organoids for COVID-19 research

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