TY - JOUR
T1 - Advances and potential of regenerative medicine in pediatric nephrology
AU - Slaats, Gisela G
AU - Chen, Junyu
AU - Levtchenko, Elena
AU - Verhaar, Marianne C
AU - Arcolino, Fanny Oliveira
N1 - Funding Information:
This work was funded by the Gravitation Program “Materials Driven Regeneration,” funded by the Netherlands Organization for Scientific Research (024.003.013) (to M.C.V.). The authors acknowledge the support of the partners of “Regenerative Medicine Crossing Borders” (RegMed XB). E. L. is supported by the ERC Consolidator grant 101045467 – NEOGRAFT.
Publisher Copyright:
© 2023, The Author(s).
PY - 2024/2
Y1 - 2024/2
N2 - The endogenous capacity of the kidney to repair is limited, and generation of new nephrons after injury for adequate function recovery remains a need. Discovery of factors that promote the endogenous regenerative capacity of the injured kidney or generation of transplantable kidney tissue represent promising therapeutic strategies. While several encouraging results are obtained after administration of stem or progenitor cells, stem cell secretome, or extracellular vesicles in experimental kidney injury models, very little data exist in the clinical setting to make conclusions about their efficacy. In this review, we provide an overview of the cutting-edge knowledge on kidney regeneration, including pre-clinical methodologies used to elucidate regenerative pathways and describe the perspectives of regenerative medicine for kidney patients.
AB - The endogenous capacity of the kidney to repair is limited, and generation of new nephrons after injury for adequate function recovery remains a need. Discovery of factors that promote the endogenous regenerative capacity of the injured kidney or generation of transplantable kidney tissue represent promising therapeutic strategies. While several encouraging results are obtained after administration of stem or progenitor cells, stem cell secretome, or extracellular vesicles in experimental kidney injury models, very little data exist in the clinical setting to make conclusions about their efficacy. In this review, we provide an overview of the cutting-edge knowledge on kidney regeneration, including pre-clinical methodologies used to elucidate regenerative pathways and describe the perspectives of regenerative medicine for kidney patients.
KW - Kidney
KW - Pediatric nephrology
KW - Regenerative medicine
UR - http://www.scopus.com/inward/record.url?scp=85163828446&partnerID=8YFLogxK
U2 - 10.1007/s00467-023-06039-0
DO - 10.1007/s00467-023-06039-0
M3 - Review article
C2 - 37400705
SN - 0931-041X
VL - 39
SP - 383
EP - 395
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 2
ER -