Adult lung function and long-term air pollution exposure. ESCAPE: A multicentre cohort study and meta-analysis

Martin Adam, Tamara Schikowski, Anne Elie Carsin, Yutong Cai, Benedicte Jacquemin, Margaux Sanchez, Andrea Vierkötter, Alessandro Marcon, Dirk Keidel, Dorothee Sugiri, Zaina Al Kanani, Rachel Nadif, Valérie Siroux, Rebecca Hardy, Diana Kuh, Thierry Rochat, Pierre Olivier Bridevaux, Marloes Eeftens, Ming Yi Tsai, Simona VillaniHarish Chandra Phuleria, Matthias Birk, Josef Cyrys, Marta Cirach, Audrey De Nazelle, Mark J. Nieuwenhuijsen, Bertil Forsberg, Kees De Hoogh, Christophe Declerq, Roberto Bono, Pavilio Piccioni, Ulrich Quass, Joachim Heinrich, Deborah Jarvis, Isabelle Pin, Rob Beelen, Gerard Hoek, Bert Brunekreef, Christian Schindler, Jordi Sunyer, Ursula Krämer, Francine Kauffmann, Anna L. Hansell, Nino Künzli, Nicole M. Probst-Hensch

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Scopus)


The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO2, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10μg·m-3 increase in NO2 exposure was associated with lower levels of FEV1 (-14.0 mL, 95% CI -25.8 to -2.1) and FVC (-14.9 mL, 95% CI -28.7 to -1.1). An increase of 10 μg·m-3 in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV1 (-44.6 mL, 95% CI -85.4 to -3.8) and FVC (-59.0 mL, 95% CI-112.3 to -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.

Original languageEnglish
Pages (from-to)38-50
Number of pages13
JournalEuropean Respiratory Journal
Issue number1
Publication statusPublished - 1 Jan 2015


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