Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines

E. Alonso De Velasco; H. A.Th Dekker; P. Antal; K. P. Jalink; J. A.G. van Strijp; A. F.M. Verheul; J. Verhoef; H. Snippe

doi:10.1016/0264-410X(94)90151-1

Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines

E. Alonso De Velasco^*
, H. A.Th Dekker
, P. Antal
, K. P. Jalink
, J. A.G. van Strijp
, A. F.M. Verheul
, J. Verhoef
, H. Snippe

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

23 Citations (Scopus)

Abstract

The adjuvant effect of Quil A on the primary antibody response of mice to pneumococcal capsular polysaccharide conjugates was examined. Quil A increased the anti-capsular polysaccharide antibody titres, the protection against Streptococcus pneumoniae, and the opsonic capacity of the antibodies as measured in a newly developed in vitro phagocytosis assay, using the mouse macrophage cell line J774.

Original language	English
Pages (from-to)	1419-1422
Number of pages	4
Journal	Vaccine
Volume	12
Issue number	15
DOIs	https://doi.org/10.1016/0264-410X(94)90151-1
Publication status	Published - 1 Jan 1994

Keywords

opsonization
Quil A
Streptococcus pneumoniae

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10.1016/0264-410X(94)90151-1

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title = "Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines",

abstract = "The adjuvant effect of Quil A on the primary antibody response of mice to pneumococcal capsular polysaccharide conjugates was examined. Quil A increased the anti-capsular polysaccharide antibody titres, the protection against Streptococcus pneumoniae, and the opsonic capacity of the antibodies as measured in a newly developed in vitro phagocytosis assay, using the mouse macrophage cell line J774.",

keywords = "opsonization, Quil A, Streptococcus pneumoniae",

author = "\{Alonso De Velasco\}, E. and Dekker, \{H. A.Th\} and P. Antal and Jalink, \{K. P.\} and \{van Strijp\}, \{J. A.G.\} and Verheul, \{A. F.M.\} and J. Verhoef and H. Snippe",

year = "1994",

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doi = "10.1016/0264-410X(94)90151-1",

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T1 - Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines

AU - Alonso De Velasco, E.

AU - Dekker, H. A.Th

AU - Antal, P.

AU - Jalink, K. P.

AU - van Strijp, J. A.G.

AU - Verheul, A. F.M.

AU - Verhoef, J.

AU - Snippe, H.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The adjuvant effect of Quil A on the primary antibody response of mice to pneumococcal capsular polysaccharide conjugates was examined. Quil A increased the anti-capsular polysaccharide antibody titres, the protection against Streptococcus pneumoniae, and the opsonic capacity of the antibodies as measured in a newly developed in vitro phagocytosis assay, using the mouse macrophage cell line J774.

AB - The adjuvant effect of Quil A on the primary antibody response of mice to pneumococcal capsular polysaccharide conjugates was examined. Quil A increased the anti-capsular polysaccharide antibody titres, the protection against Streptococcus pneumoniae, and the opsonic capacity of the antibodies as measured in a newly developed in vitro phagocytosis assay, using the mouse macrophage cell line J774.

KW - opsonization

KW - Quil A

KW - Streptococcus pneumoniae

UR - https://www.scopus.com/pages/publications/0027996785

U2 - 10.1016/0264-410X(94)90151-1

DO - 10.1016/0264-410X(94)90151-1

M3 - Article

C2 - 7887020

AN - SCOPUS:0027996785

SN - 0264-410X

VL - 12

SP - 1419

EP - 1422

JO - Vaccine

JF - Vaccine

IS - 15

ER -

Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines

Abstract

Keywords

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