TY - JOUR
T1 - Adjuvant oestrogen therapy does not improve disease activity in postmenopausal patients with rheumatoid arthritis
AU - Van den Brink, H. R.
AU - Van Everdingen, A. A.
AU - Van Wijk, M. J.G.
AU - Jacobs, J. W.G.
AU - Bijlsma, J. W.J.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Objective - To investigate whether oestrogens can be used as treatment to diminish disease activity in women with rheumatoid arthritis. Methods - Forty postmenopausal female patients with active rheumatoid arthritis participated in a placebo-controlled, double-blind study on the possible beneficial effect of adjuvant treatment of oestradiol on disease activity. Results - Thirty three patients completed 52 weeks of treatment with 2 mg oestradiolvalerate or placebo. No statistically significant difference was found in and between both treatment groups with regard to articular indices, pain score by visual analogue scale, erythrocyte sedimentation rate and health questionnaire on daily activities before, during and at the end of the study. Conclusion - This first randomised prospective placebo-controlled study shows no beneficial effect of oestrogens on disease activity in postmenopausal female patients with rheumatoid arthritis.
AB - Objective - To investigate whether oestrogens can be used as treatment to diminish disease activity in women with rheumatoid arthritis. Methods - Forty postmenopausal female patients with active rheumatoid arthritis participated in a placebo-controlled, double-blind study on the possible beneficial effect of adjuvant treatment of oestradiol on disease activity. Results - Thirty three patients completed 52 weeks of treatment with 2 mg oestradiolvalerate or placebo. No statistically significant difference was found in and between both treatment groups with regard to articular indices, pain score by visual analogue scale, erythrocyte sedimentation rate and health questionnaire on daily activities before, during and at the end of the study. Conclusion - This first randomised prospective placebo-controlled study shows no beneficial effect of oestrogens on disease activity in postmenopausal female patients with rheumatoid arthritis.
UR - http://www.scopus.com/inward/record.url?scp=0027746256&partnerID=8YFLogxK
U2 - 10.1136/ard.52.12.862
DO - 10.1136/ard.52.12.862
M3 - Article
C2 - 8311536
AN - SCOPUS:0027746256
SN - 0003-4967
VL - 52
SP - 862
EP - 865
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 12
ER -