TY - JOUR
T1 - Adipose Tissue Dysfunction
T2 - Clinical Relevance and Diagnostic Possibilities
AU - Schrover, I. M.
AU - Spiering, W.
AU - Leiner, T.
AU - Visseren, F. L J
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Adipose tissue dysfunction is defined as an imbalance between pro- and anti-inflammatory adipokines, causing insulin resistance, systemic low-grade inflammation, hypercoagulability, and elevated blood pressure. These can lead to cardiovascular disease and diabetes mellitus type 2. Although quantity of adipose tissue is an important determinant of adipose tissue dysfunction, it can be diagnosed in both obese and lean individuals. This implies that not only quantity of adipose tissue should be used as a measure for adipose tissue dysfunction. Instead, focus should be on measuring quality of adipose tissue, which can be done with diagnostic modalities ranging from anthropometric measurements to tissue biopsies and advanced imaging techniques. In daily clinical practice, high quantity of visceral adipose tissue (reflected in high waist circumference or adipose tissue imaging), insulin resistance, or presence of the metabolic syndrome are easy and low-cost diagnostic modalities to evaluate presence or absence of adipose tissue dysfunction.
AB - Adipose tissue dysfunction is defined as an imbalance between pro- and anti-inflammatory adipokines, causing insulin resistance, systemic low-grade inflammation, hypercoagulability, and elevated blood pressure. These can lead to cardiovascular disease and diabetes mellitus type 2. Although quantity of adipose tissue is an important determinant of adipose tissue dysfunction, it can be diagnosed in both obese and lean individuals. This implies that not only quantity of adipose tissue should be used as a measure for adipose tissue dysfunction. Instead, focus should be on measuring quality of adipose tissue, which can be done with diagnostic modalities ranging from anthropometric measurements to tissue biopsies and advanced imaging techniques. In daily clinical practice, high quantity of visceral adipose tissue (reflected in high waist circumference or adipose tissue imaging), insulin resistance, or presence of the metabolic syndrome are easy and low-cost diagnostic modalities to evaluate presence or absence of adipose tissue dysfunction.
KW - adipose tissue
KW - diagnosis
KW - dysfunction
KW - metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=84964459435&partnerID=8YFLogxK
U2 - 10.1055/s-0042-103243
DO - 10.1055/s-0042-103243
M3 - Literature review
C2 - 27065460
AN - SCOPUS:84964459435
SN - 0018-5043
VL - 48
SP - 213
EP - 225
JO - Hormone and metabolic research
JF - Hormone and metabolic research
IS - 4
ER -