Adipose tissue-derived stromal/stem cells

J. V. Korpershoek; K. L. Lydon; D. B.F. Saris

doi:10.1016/B978-0-12-822902-6.00009-X

Adipose tissue-derived stromal/stem cells

J. V. Korpershoek, K. L. Lydon, D. B.F. Saris

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Adipose tissue-derived mesenchymal stromal cells (MSCs) are an orthobiologic that is derived from adipose tissue, allowing use in both allogeneic and autologous applications. This chapter covers the isolation and expansion of adipose MSCs and the mechanisms of action that make adipose MSCs an attractive orthobiologic. The requirements for in vitro trilineage differentiation are described, and the evidence of in vivo cartilage and bone regeneration by adipose MSCs is evaluated. Furthermore, the mechanisms behind chondroinduction are provided. Finally, the processes contributing to the immunomodulatory effects of adipose MSCs are described. To date, osteoconduction, chondroinduction, and immunomodulation seem to be the most essential processes for this orthobiologic. The importance of other processes might be elucidated through future research, and the behavior of MSCs in vivo remains largely unknown.

Original language	English
Title of host publication	OrthoBiologics
Editors	R.M. Frank, G.R. Jackson, J. Chahla
Publisher	Elsevier
Pages	73-80
Number of pages	8
ISBN (Electronic)	9780128229026
ISBN (Print)	9780128229033
DOIs	https://doi.org/10.1016/B978-0-12-822902-6.00009-X
Publication status	Published - 2024

Keywords

Adipose tissue
antiinflammatory
ASC
chondroinduction
differentiation
immunomodulation
MSCs
regeneration

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10.1016/B978-0-12-822902-6.00009-X

Cite this

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abstract = "Adipose tissue-derived mesenchymal stromal cells (MSCs) are an orthobiologic that is derived from adipose tissue, allowing use in both allogeneic and autologous applications. This chapter covers the isolation and expansion of adipose MSCs and the mechanisms of action that make adipose MSCs an attractive orthobiologic. The requirements for in vitro trilineage differentiation are described, and the evidence of in vivo cartilage and bone regeneration by adipose MSCs is evaluated. Furthermore, the mechanisms behind chondroinduction are provided. Finally, the processes contributing to the immunomodulatory effects of adipose MSCs are described. To date, osteoconduction, chondroinduction, and immunomodulation seem to be the most essential processes for this orthobiologic. The importance of other processes might be elucidated through future research, and the behavior of MSCs in vivo remains largely unknown.",

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AB - Adipose tissue-derived mesenchymal stromal cells (MSCs) are an orthobiologic that is derived from adipose tissue, allowing use in both allogeneic and autologous applications. This chapter covers the isolation and expansion of adipose MSCs and the mechanisms of action that make adipose MSCs an attractive orthobiologic. The requirements for in vitro trilineage differentiation are described, and the evidence of in vivo cartilage and bone regeneration by adipose MSCs is evaluated. Furthermore, the mechanisms behind chondroinduction are provided. Finally, the processes contributing to the immunomodulatory effects of adipose MSCs are described. To date, osteoconduction, chondroinduction, and immunomodulation seem to be the most essential processes for this orthobiologic. The importance of other processes might be elucidated through future research, and the behavior of MSCs in vivo remains largely unknown.

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KW - antiinflammatory

KW - ASC

KW - chondroinduction

KW - differentiation

KW - immunomodulation

KW - MSCs

KW - regeneration

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Adipose tissue-derived stromal/stem cells

Abstract

Keywords

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