TY - JOUR
T1 - Adipokines and inflammation markers and risk of differentiated thyroid carcinoma
T2 - The EPIC study
AU - Dossus, Laure
AU - Franceschi, Silvia
AU - Biessy, Carine
AU - Navionis, Anne-Sophie
AU - Travis, Ruth C.
AU - Weiderpass, Elisabete
AU - Scalbert, Augustin
AU - Romieu, Isabelle
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Overvad, Kim
AU - Boutron-Ruault, Marie Christine
AU - Bonnet, Fabrice
AU - Fournier, Agnès
AU - Fortner, Renee T.
AU - Kaaks, Rudolf
AU - Aleksandrova, Krasimira
AU - Trichopoulou, Antonia
AU - La Vecchia, Carlo
AU - Peppa, Eleni
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Palli, Domenico
AU - Agnoli, Claudia
AU - Vineis, Paolo
AU - Bueno-de-Mesquita, H B As
AU - Peeters, Petra H
AU - Skeie, Guri
AU - Zamora-Ros, Raul
AU - Chirlaque, María-Dolores
AU - Ardanaz, Eva
AU - Sánchez, Maria-Jose
AU - Ramón Quirós, Jose
AU - Dorronsoro, Miren
AU - Sandström, Maria
AU - Nilsson, Lena Maria
AU - Schmidt, Julie A.
AU - Khaw, Kay Tee
AU - Tsilidis, Konstantinos K.
AU - Aune, Dagfinn
AU - Riboli, Elio
AU - Rinaldi, Sabina
N1 - Publisher Copyright:
© 2017 International Agency for Research on Cancer (IARC/WHO); licensed by UICC
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1 = 0.69, 95% CI: 0.49-0.98, Ptrend = 0.04) but not among men (ORT3vs.T1 = 1.36, 95% CI: 0.67-2.76, Ptrend = 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1 = 1.59, 95% CI: 1.13-2.25, Ptrend = 0.01) but not in men (ORT3vs.T1 = 1.78, 95% CI: 0.80-3.98, Ptrend = 0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.
AB - Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1 = 0.69, 95% CI: 0.49-0.98, Ptrend = 0.04) but not among men (ORT3vs.T1 = 1.36, 95% CI: 0.67-2.76, Ptrend = 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1 = 1.59, 95% CI: 1.13-2.25, Ptrend = 0.01) but not in men (ORT3vs.T1 = 1.78, 95% CI: 0.80-3.98, Ptrend = 0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.
KW - adipokine
KW - cytokine
KW - inflammation
KW - prospective cohort
KW - thyroid cancer
U2 - 10.1002/ijc.31172
DO - 10.1002/ijc.31172
M3 - Article
C2 - 29168186
SN - 0020-7136
VL - 142
SP - 1332
EP - 1342
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 7
ER -