Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: a very strong risk factor for adenovirus DNAemia in pediatric patients

Anne P J de Pagter; Lianne M Haveman; Rob Schuurman; Martin Schutten; Marc Bierings; Jaap-Jan Boelens

doi:10.1086/644739

Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: a very strong risk factor for adenovirus DNAemia in pediatric patients

Anne P J de Pagter
, Lianne M Haveman
, Rob Schuurman
, Martin Schutten
, Marc Bierings
, Jaap-Jan Boelens

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.

Original language	English
Pages (from-to)	1536-1539
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	49
Issue number	10
DOIs	https://doi.org/10.1086/644739
Publication status	Published - 15 Nov 2009

Keywords

Adenoviridae Infections
Adenoviruses, Human
Adolescent
Carrier State
Child
Child, Preschool
DNA, Viral
Female
Graft Rejection
Hematopoietic Stem Cell Transplantation
Humans
Infant
Infant, Newborn
Male
Nasopharynx
Prevalence
Prospective Studies
Risk Factors
Viremia
Young Adult

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10.1086/644739

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@article{46622ba671b3499faf4916f3ffb8a77e,

title = "Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: a very strong risk factor for adenovirus DNAemia in pediatric patients",

abstract = "Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.",

keywords = "Adenoviridae Infections, Adenoviruses, Human, Adolescent, Carrier State, Child, Child, Preschool, DNA, Viral, Female, Graft Rejection, Hematopoietic Stem Cell Transplantation, Humans, Infant, Infant, Newborn, Male, Nasopharynx, Prevalence, Prospective Studies, Risk Factors, Viremia, Young Adult",

author = "\{de Pagter\}, \{Anne P J\} and Haveman, \{Lianne M\} and Rob Schuurman and Martin Schutten and Marc Bierings and Jaap-Jan Boelens",

year = "2009",

month = nov,

day = "15",

doi = "10.1086/644739",

language = "English",

volume = "49",

pages = "1536--1539",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "10",

}

Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: a very strong risk factor for adenovirus DNAemia in pediatric patients. / de Pagter, Anne P J; Haveman, Lianne M; Schuurman, Rob et al.
In: Clinical Infectious Diseases, Vol. 49, No. 10, 15.11.2009, p. 1536-1539.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation

T2 - a very strong risk factor for adenovirus DNAemia in pediatric patients

AU - de Pagter, Anne P J

AU - Haveman, Lianne M

AU - Schuurman, Rob

AU - Schutten, Martin

AU - Bierings, Marc

AU - Boelens, Jaap-Jan

PY - 2009/11/15

Y1 - 2009/11/15

N2 - Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.

AB - Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.

KW - Adenoviridae Infections

KW - Adenoviruses, Human

KW - Adolescent

KW - Carrier State

KW - Child

KW - Child, Preschool

KW - DNA, Viral

KW - Female

KW - Graft Rejection

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Nasopharynx

KW - Prevalence

KW - Prospective Studies

KW - Risk Factors

KW - Viremia

KW - Young Adult

U2 - 10.1086/644739

DO - 10.1086/644739

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C2 - 19845474

SN - 1058-4838

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SP - 1536

EP - 1539

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 10

ER -

Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: a very strong risk factor for adenovirus DNAemia in pediatric patients

Abstract

Keywords

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