Additional value of a high sensitive thyroglobulin assay in the follow-up of patients with differentiated thyroid carcinoma

Andries H. Groen; Mariëlle S. Klein Hesselink; John T M Plukker; Wim J. Sluiter; Anouk N A van der Horst-Schrivers; Adrienne H. Brouwers; Eef G W M Lentjes; Anneke C. Muller Kobold; Thera P. Links

doi:10.1111/cen.13180

Additional value of a high sensitive thyroglobulin assay in the follow-up of patients with differentiated thyroid carcinoma

Andries H. Groen, Mariëlle S. Klein Hesselink, John T M Plukker, Wim J. Sluiter, Anouk N A van der Horst-Schrivers, Adrienne H. Brouwers, Eef G W M Lentjes, Anneke C. Muller Kobold, Thera P. Links^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: Thyroglobulin (Tg) is an excellent tumour marker, as detectable or increasing Tg levels are highly indicative of persistent or recurrent differentiated thyroid carcinoma (DTC). The clinical value of a highly sensitive (hs)-Tg assay in patients with DTC has not yet been established. The aim of this study was to investigate the additional value of unstimulated hs-Tg measurements (Tg-on) compared to stimulated IRMA-Tg measurements (Tg-off) in the follow-up of patients with DTC.

DESIGN, PATIENTS, MEASUREMENTS: We retrospectively studied patients treated for DTC between 2006 and 2013 and compared hs-Tg and IRMA-Tg measurements. The study group consisted of 99 DTC patients in remission; Tg-on was measured 3 months after remnant ablation and Tg-off 6 months after ablation.

RESULTS: In the study group, 44 patients showed a hs-Tg-on <0·15 μg/l (functional sensitivity); of these, 43 had an IRMA-Tg-off measurement <1·0 μg/l, resulting in a negative predictive value of 97·7% and a positive predictive value of 56·4%.

CONCLUSIONS: The hs-Tg-on measurement is able to predict patients with an IRMA-Tg-off <1·0 μg/l, and therefore decreases the need for Tg stimulation after ablation.

Original language	English
Pages (from-to)	419-424
Number of pages	6
Journal	Clinical Endocrinology
Volume	86
Issue number	3
DOIs	https://doi.org/10.1111/cen.13180
Publication status	Published - Mar 2017

Keywords

Adult
Biomarkers, Tumor/blood
Catheter Ablation
Female
Follow-Up Studies
Humans
Male
Middle Aged
Postoperative Period
Predictive Value of Tests
Remission Induction
Retrospective Studies
Thyroglobulin/blood
Thyroid Function Tests/methods
Thyroid Neoplasms/diagnosis

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10.1111/cen.13180

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Groen, A. H., Klein Hesselink, M. S., Plukker, J. T. M., Sluiter, W. J., van der Horst-Schrivers, A. N. A., Brouwers, A. H., Lentjes, E. G. W. M., Muller Kobold, A. C., & Links, T. P. (2017). Additional value of a high sensitive thyroglobulin assay in the follow-up of patients with differentiated thyroid carcinoma. Clinical Endocrinology, 86(3), 419-424. https://doi.org/10.1111/cen.13180

@article{641b243726e64587971cac744444154b,

title = "Additional value of a high sensitive thyroglobulin assay in the follow-up of patients with differentiated thyroid carcinoma",

abstract = "OBJECTIVE: Thyroglobulin (Tg) is an excellent tumour marker, as detectable or increasing Tg levels are highly indicative of persistent or recurrent differentiated thyroid carcinoma (DTC). The clinical value of a highly sensitive (hs)-Tg assay in patients with DTC has not yet been established. The aim of this study was to investigate the additional value of unstimulated hs-Tg measurements (Tg-on) compared to stimulated IRMA-Tg measurements (Tg-off) in the follow-up of patients with DTC.DESIGN, PATIENTS, MEASUREMENTS: We retrospectively studied patients treated for DTC between 2006 and 2013 and compared hs-Tg and IRMA-Tg measurements. The study group consisted of 99 DTC patients in remission; Tg-on was measured 3 months after remnant ablation and Tg-off 6 months after ablation.RESULTS: In the study group, 44 patients showed a hs-Tg-on <0·15 μg/l (functional sensitivity); of these, 43 had an IRMA-Tg-off measurement <1·0 μg/l, resulting in a negative predictive value of 97·7% and a positive predictive value of 56·4%.CONCLUSIONS: The hs-Tg-on measurement is able to predict patients with an IRMA-Tg-off <1·0 μg/l, and therefore decreases the need for Tg stimulation after ablation.",

keywords = "Adult, Biomarkers, Tumor/blood, Catheter Ablation, Female, Follow-Up Studies, Humans, Male, Middle Aged, Postoperative Period, Predictive Value of Tests, Remission Induction, Retrospective Studies, Thyroglobulin/blood, Thyroid Function Tests/methods, Thyroid Neoplasms/diagnosis",

author = "Groen, {Andries H.} and {Klein Hesselink}, {Mari{\"e}lle S.} and Plukker, {John T M} and Sluiter, {Wim J.} and {van der Horst-Schrivers}, {Anouk N A} and Brouwers, {Adrienne H.} and Lentjes, {Eef G W M} and {Muller Kobold}, {Anneke C.} and Links, {Thera P.}",

note = "Funding Information: The hs-Tg assay was donated by Thermo Fisher. T.P. Links received an unrestricted research support grant from Genzyme. The other authors have nothing to declare. We would like to thank the technicians of the laboratory of Binding Analysis of the University Medical Center Groningen for their help. Publisher Copyright: {\textcopyright} 2016 John Wiley & Sons Ltd",

year = "2017",

month = mar,

doi = "10.1111/cen.13180",

language = "English",

volume = "86",

pages = "419--424",

journal = "Clinical Endocrinology",

issn = "0300-0664",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - Additional value of a high sensitive thyroglobulin assay in the follow-up of patients with differentiated thyroid carcinoma

AU - Groen, Andries H.

AU - Klein Hesselink, Mariëlle S.

AU - Plukker, John T M

AU - Sluiter, Wim J.

AU - van der Horst-Schrivers, Anouk N A

AU - Brouwers, Adrienne H.

AU - Lentjes, Eef G W M

AU - Muller Kobold, Anneke C.

AU - Links, Thera P.

N1 - Funding Information: The hs-Tg assay was donated by Thermo Fisher. T.P. Links received an unrestricted research support grant from Genzyme. The other authors have nothing to declare. We would like to thank the technicians of the laboratory of Binding Analysis of the University Medical Center Groningen for their help. Publisher Copyright: © 2016 John Wiley & Sons Ltd

PY - 2017/3

Y1 - 2017/3

N2 - OBJECTIVE: Thyroglobulin (Tg) is an excellent tumour marker, as detectable or increasing Tg levels are highly indicative of persistent or recurrent differentiated thyroid carcinoma (DTC). The clinical value of a highly sensitive (hs)-Tg assay in patients with DTC has not yet been established. The aim of this study was to investigate the additional value of unstimulated hs-Tg measurements (Tg-on) compared to stimulated IRMA-Tg measurements (Tg-off) in the follow-up of patients with DTC.DESIGN, PATIENTS, MEASUREMENTS: We retrospectively studied patients treated for DTC between 2006 and 2013 and compared hs-Tg and IRMA-Tg measurements. The study group consisted of 99 DTC patients in remission; Tg-on was measured 3 months after remnant ablation and Tg-off 6 months after ablation.RESULTS: In the study group, 44 patients showed a hs-Tg-on <0·15 μg/l (functional sensitivity); of these, 43 had an IRMA-Tg-off measurement <1·0 μg/l, resulting in a negative predictive value of 97·7% and a positive predictive value of 56·4%.CONCLUSIONS: The hs-Tg-on measurement is able to predict patients with an IRMA-Tg-off <1·0 μg/l, and therefore decreases the need for Tg stimulation after ablation.

AB - OBJECTIVE: Thyroglobulin (Tg) is an excellent tumour marker, as detectable or increasing Tg levels are highly indicative of persistent or recurrent differentiated thyroid carcinoma (DTC). The clinical value of a highly sensitive (hs)-Tg assay in patients with DTC has not yet been established. The aim of this study was to investigate the additional value of unstimulated hs-Tg measurements (Tg-on) compared to stimulated IRMA-Tg measurements (Tg-off) in the follow-up of patients with DTC.DESIGN, PATIENTS, MEASUREMENTS: We retrospectively studied patients treated for DTC between 2006 and 2013 and compared hs-Tg and IRMA-Tg measurements. The study group consisted of 99 DTC patients in remission; Tg-on was measured 3 months after remnant ablation and Tg-off 6 months after ablation.RESULTS: In the study group, 44 patients showed a hs-Tg-on <0·15 μg/l (functional sensitivity); of these, 43 had an IRMA-Tg-off measurement <1·0 μg/l, resulting in a negative predictive value of 97·7% and a positive predictive value of 56·4%.CONCLUSIONS: The hs-Tg-on measurement is able to predict patients with an IRMA-Tg-off <1·0 μg/l, and therefore decreases the need for Tg stimulation after ablation.

KW - Adult

KW - Biomarkers, Tumor/blood

KW - Catheter Ablation

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Postoperative Period

KW - Predictive Value of Tests

KW - Remission Induction

KW - Retrospective Studies

KW - Thyroglobulin/blood

KW - Thyroid Function Tests/methods

KW - Thyroid Neoplasms/diagnosis

UR - http://www.scopus.com/inward/record.url?scp=84995511389&partnerID=8YFLogxK

U2 - 10.1111/cen.13180

DO - 10.1111/cen.13180

M3 - Article

C2 - 27588675

AN - SCOPUS:84995511389

SN - 0300-0664

VL - 86

SP - 419

EP - 424

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 3

ER -

Additional value of a high sensitive thyroglobulin assay in the follow-up of patients with differentiated thyroid carcinoma

Abstract

Keywords

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