TY - JOUR
T1 - Additional diagnostic value of cardiac magnetic resonance feature tracking in patients with biopsy-proven arrhythmogenic cardiomyopathy
AU - Muscogiuri, Giuseppe
AU - Fusini, Laura
AU - Ricci, Francesca
AU - Sicuso, Rita
AU - Guglielmo, Marco
AU - Baggiano, Andrea
AU - Gasperetti, Alessio
AU - Casella, Michela
AU - Mushtaq, Saima
AU - Conte, Edoardo
AU - Annoni, Andrea
AU - Formenti, Alberto
AU - Mancini, Maria Elisabetta
AU - Babbaro, Mario
AU - Mollace, Rocco
AU - Collevecchio, Ada
AU - Scafuri, Stefano
AU - Kukavica, Deni
AU - Andreini, Daniele
AU - Basso, Cristina
AU - Rizzo, Stefania
AU - De Gaspari, Monica
AU - Priori, Silvia
AU - Dello Russo, Antonio
AU - Tondo, Claudio
AU - Pepi, Mauro
AU - Sommariva, Elena
AU - Rabbat, Mark
AU - Guaricci, Andrea Igoren
AU - Pontone, Gianluca
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/9/15
Y1 - 2021/9/15
N2 - Background: We aim to evaluate the value of Cardiac magnetic resonance (CMR) feature tracking (CMR-FT) in addition to Task Force Criteria(TFC) in patients with (arrhythmogenic cardiomyopathy) AC biopsy-proved. Methods: Thirty-five patients with AC histologically proven who performed CMR with late gadolinium enhancement (LGE) acquisition were enrolled. The study population was divided in Group1 (negative CMR TFC and LV ejection fraction≥55%) and Group2 (positive CMR TFC and/or LVEF<55%) and compared to an age and gender-matched control group. CMR datasets of all patients were analyzed to calculate LV indexed end-diastolic (LVEDi) and end-systolic (LVESi) volumes and RV indexed end-diastolic (RVEDi) and end-systolic (RVESi) volumes, both LV ejection fraction (LVEF) and RV ejection fraction (RVEF). Moreover, LV and RV global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain were measured. Results: The AC patients showed both higher LVEDi (p:0.002) and RVEDi (p:0.017) and lower LVEF (p: 0.016) as compared to control patients. Moreover, AC patients showed impaired LV-GLS (p < 0.001), LV-GRS (p < 0.001), LV-GCS (p < 0.001) and RV-GRS (p:0.026) as compared to control subjects. Group1 patients showed a significant reduction of LV-GRS (p < 0.05) and LV-GCS p < 0.01) as compared to control subjects. At univariate analysis LV-GCS was the most discriminatory parameter between Group1 vs heathy subjects with an optimal cut-off of −15.8 (Sensitivity: 74%; Specificity: 10%). Conclusions: In patients with AC biopsy-proven, CMR-FT could improve the diagnostic yield in the subset of patients who results negative for imaging TFC criteria resulting as useful gatekeeper for indication of myocardial biopsy in case of equivocal clinical and imaging presentation.
AB - Background: We aim to evaluate the value of Cardiac magnetic resonance (CMR) feature tracking (CMR-FT) in addition to Task Force Criteria(TFC) in patients with (arrhythmogenic cardiomyopathy) AC biopsy-proved. Methods: Thirty-five patients with AC histologically proven who performed CMR with late gadolinium enhancement (LGE) acquisition were enrolled. The study population was divided in Group1 (negative CMR TFC and LV ejection fraction≥55%) and Group2 (positive CMR TFC and/or LVEF<55%) and compared to an age and gender-matched control group. CMR datasets of all patients were analyzed to calculate LV indexed end-diastolic (LVEDi) and end-systolic (LVESi) volumes and RV indexed end-diastolic (RVEDi) and end-systolic (RVESi) volumes, both LV ejection fraction (LVEF) and RV ejection fraction (RVEF). Moreover, LV and RV global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain were measured. Results: The AC patients showed both higher LVEDi (p:0.002) and RVEDi (p:0.017) and lower LVEF (p: 0.016) as compared to control patients. Moreover, AC patients showed impaired LV-GLS (p < 0.001), LV-GRS (p < 0.001), LV-GCS (p < 0.001) and RV-GRS (p:0.026) as compared to control subjects. Group1 patients showed a significant reduction of LV-GRS (p < 0.05) and LV-GCS p < 0.01) as compared to control subjects. At univariate analysis LV-GCS was the most discriminatory parameter between Group1 vs heathy subjects with an optimal cut-off of −15.8 (Sensitivity: 74%; Specificity: 10%). Conclusions: In patients with AC biopsy-proven, CMR-FT could improve the diagnostic yield in the subset of patients who results negative for imaging TFC criteria resulting as useful gatekeeper for indication of myocardial biopsy in case of equivocal clinical and imaging presentation.
KW - Arrhythmogenic cardiomyopathy
KW - Myocardial biopsy
KW - Myocardial strain
UR - http://www.scopus.com/inward/record.url?scp=85110479453&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2021.06.052
DO - 10.1016/j.ijcard.2021.06.052
M3 - Article
C2 - 34242689
AN - SCOPUS:85110479453
SN - 0167-5273
VL - 339
SP - 203
EP - 210
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -