Added value of non-rigid image registration for intrafraction dose accumulation in magnetic resonance imaging-guided prostate radiotherapy

Georgios Tsekas; Cornel Zachiu; Gijsbert H. Bol; Johannes C.J. de Boer; Bas W. Raaymakers

doi:10.1016/j.phro.2025.100711

Added value of non-rigid image registration for intrafraction dose accumulation in magnetic resonance imaging-guided prostate radiotherapy

Georgios Tsekas^*
, Cornel Zachiu
, Gijsbert H. Bol
, Johannes C.J. de Boer
, Bas W. Raaymakers

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

This work investigates potential advantages of non-rigid versus rigid image registration for intrafraction dose reconstruction in hypofractionated prostate radiotherapy. The data of 15 patients were analyzed using 3D cine magnetic resonance imaging (MRI) in combination with machine log files and the accumulated dose distributions were compared to the planned ones. Both image registration methods resulted in comparable results for the majority ( ∼ 95%) of patient fractions. However, better image alignment was reported for the non-rigid method compared to rigid in cases of transient gas pockets, indicating better image registration quality in the presence of large intrafraction deformations.

Original language	English
Article number	100711
Journal	Physics and Imaging in Radiation Oncology
Volume	33
DOIs	https://doi.org/10.1016/j.phro.2025.100711
Publication status	Published - Jan 2025

Keywords

Adaptive radiotherapy
Deformable image registration
Hypofractionated radiotherapy
Intrafraction motion
Prostate cancer
Rigid image registration

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10.1016/j.phro.2025.100711Licence: CC BY

PIIS2405631625000168Final published version, 931 KBLicence: CC BY

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title = "Added value of non-rigid image registration for intrafraction dose accumulation in magnetic resonance imaging-guided prostate radiotherapy",

abstract = "This work investigates potential advantages of non-rigid versus rigid image registration for intrafraction dose reconstruction in hypofractionated prostate radiotherapy. The data of 15 patients were analyzed using 3D cine magnetic resonance imaging (MRI) in combination with machine log files and the accumulated dose distributions were compared to the planned ones. Both image registration methods resulted in comparable results for the majority ( ∼ 95\%) of patient fractions. However, better image alignment was reported for the non-rigid method compared to rigid in cases of transient gas pockets, indicating better image registration quality in the presence of large intrafraction deformations.",

keywords = "Adaptive radiotherapy, Deformable image registration, Hypofractionated radiotherapy, Intrafraction motion, Prostate cancer, Rigid image registration",

author = "Georgios Tsekas and Cornel Zachiu and Bol, \{Gijsbert H.\} and \{de Boer\}, \{Johannes C.J.\} and Raaymakers, \{Bas W.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

month = jan,

doi = "10.1016/j.phro.2025.100711",

language = "English",

volume = "33",

journal = "Physics and Imaging in Radiation Oncology",

issn = "2405-6316",

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TY - JOUR

T1 - Added value of non-rigid image registration for intrafraction dose accumulation in magnetic resonance imaging-guided prostate radiotherapy

AU - Tsekas, Georgios

AU - Zachiu, Cornel

AU - Bol, Gijsbert H.

AU - de Boer, Johannes C.J.

AU - Raaymakers, Bas W.

PY - 2025/1

Y1 - 2025/1

N2 - This work investigates potential advantages of non-rigid versus rigid image registration for intrafraction dose reconstruction in hypofractionated prostate radiotherapy. The data of 15 patients were analyzed using 3D cine magnetic resonance imaging (MRI) in combination with machine log files and the accumulated dose distributions were compared to the planned ones. Both image registration methods resulted in comparable results for the majority ( ∼ 95%) of patient fractions. However, better image alignment was reported for the non-rigid method compared to rigid in cases of transient gas pockets, indicating better image registration quality in the presence of large intrafraction deformations.

AB - This work investigates potential advantages of non-rigid versus rigid image registration for intrafraction dose reconstruction in hypofractionated prostate radiotherapy. The data of 15 patients were analyzed using 3D cine magnetic resonance imaging (MRI) in combination with machine log files and the accumulated dose distributions were compared to the planned ones. Both image registration methods resulted in comparable results for the majority ( ∼ 95%) of patient fractions. However, better image alignment was reported for the non-rigid method compared to rigid in cases of transient gas pockets, indicating better image registration quality in the presence of large intrafraction deformations.

KW - Adaptive radiotherapy

KW - Deformable image registration

KW - Hypofractionated radiotherapy

KW - Intrafraction motion

KW - Prostate cancer

KW - Rigid image registration

UR - https://www.scopus.com/pages/publications/85217222677

U2 - 10.1016/j.phro.2025.100711

DO - 10.1016/j.phro.2025.100711

M3 - Article

AN - SCOPUS:85217222677

SN - 2405-6316

VL - 33

JO - Physics and Imaging in Radiation Oncology

JF - Physics and Imaging in Radiation Oncology

M1 - 100711

ER -

Added value of non-rigid image registration for intrafraction dose accumulation in magnetic resonance imaging-guided prostate radiotherapy

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