TY - JOUR
T1 - ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects
AU - Manzine, Patricia Regina
AU - Marcello, Elena
AU - Borroni, Barbara
AU - Kamphuis, Willem
AU - Hol, Elly
AU - Padovani, Alessandro
AU - Nascimento, Carla Crispim
AU - De Godoy Bueno, Patricia
AU - Assis Carvalho Vale, Francisco
AU - Iost Pavarini, Sofia Cristina
AU - Di Luca, Monica
AU - Cominetti, Márcia Regina
PY - 2015/1/1
Y1 - 2015/1/1
N2 - ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No significant differences in ADAM10 gene expression were observed. Therefore, the decrease of ADAM10 protein in platelets of AD patients is not caused by a reduction in ADAM10 mRNA. Further studies must be performed to investigate other pathways in the down regulation of ADAM10 protein.
AB - ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No significant differences in ADAM10 gene expression were observed. Therefore, the decrease of ADAM10 protein in platelets of AD patients is not caused by a reduction in ADAM10 mRNA. Further studies must be performed to investigate other pathways in the down regulation of ADAM10 protein.
KW - Aging
KW - biomarkers
KW - blood
KW - platelets
UR - https://www.scopus.com/pages/publications/84940453816
U2 - 10.3109/1354750X.2015.1062554
DO - 10.3109/1354750X.2015.1062554
M3 - Article
AN - SCOPUS:84940453816
SN - 1354-750X
VL - 20
SP - 196
EP - 201
JO - Biomarkers
JF - Biomarkers
IS - 3
ER -