ACQUISITION AND QUANTITATION IN PROTON SPECTROSCOPY

PR LUYTEN; AJH MARIEN; JA DENHOLLANDER

ACQUISITION AND QUANTITATION IN PROTON SPECTROSCOPY

PR LUYTEN^*, AJH MARIEN, JA DENHOLLANDER

^*Corresponding author for this work

Highfield Research Group

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Localized proton NMR spectroscopy in the human brain is one of the more technically advanced applications of human in vivo NMR spectroscopy. Spin/echo techniques introduced reliable localization procedures, whereas the introduction of phase encoding techniques improved the spatial information content considerably. Using the sensitivity of the H-1 NMR signal, a spatial resolution of 7 x 7 x 15 mm can be obtained. Chemical shift images can be reconstructed to represent the choline, creatine, N-acetyl aspartate and lactate distribution in the human brain. These low resolution images may be used as a new functional imaging modality to visualize and derive quantitative biochemical information from focal brain lesions under normal and pathological conditions.

Original language	English
Pages (from-to)	64-69
Number of pages	6
Journal	NMR in Biomedicine
Volume	4
Issue number	2
Publication status	Published - Apr 1991

Keywords

NUCLEAR MAGNETIC-RESONANCE
NMR-SPECTROSCOPY
HUMAN-BRAIN
SELECTIVE EXCITATION
INVIVO SPECTROSCOPY
INTRACRANIAL TUMORS
STIMULATED ECHOES
LOCALIZATION
METABOLITES
INVERSION

Cite this

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title = "ACQUISITION AND QUANTITATION IN PROTON SPECTROSCOPY",

abstract = "Localized proton NMR spectroscopy in the human brain is one of the more technically advanced applications of human in vivo NMR spectroscopy. Spin/echo techniques introduced reliable localization procedures, whereas the introduction of phase encoding techniques improved the spatial information content considerably. Using the sensitivity of the H-1 NMR signal, a spatial resolution of 7 x 7 x 15 mm can be obtained. Chemical shift images can be reconstructed to represent the choline, creatine, N-acetyl aspartate and lactate distribution in the human brain. These low resolution images may be used as a new functional imaging modality to visualize and derive quantitative biochemical information from focal brain lesions under normal and pathological conditions.",

keywords = "NUCLEAR MAGNETIC-RESONANCE, NMR-SPECTROSCOPY, HUMAN-BRAIN, SELECTIVE EXCITATION, INVIVO SPECTROSCOPY, INTRACRANIAL TUMORS, STIMULATED ECHOES, LOCALIZATION, METABOLITES, INVERSION",

author = "PR LUYTEN and AJH MARIEN and JA DENHOLLANDER",

year = "1991",

month = apr,

language = "English",

volume = "4",

pages = "64--69",

journal = "NMR in Biomedicine",

issn = "0952-3480",

publisher = "John Wiley & Sons Inc.",

number = "2",

}

TY - JOUR

T1 - ACQUISITION AND QUANTITATION IN PROTON SPECTROSCOPY

AU - LUYTEN, PR

AU - MARIEN, AJH

AU - DENHOLLANDER, JA

PY - 1991/4

Y1 - 1991/4

N2 - Localized proton NMR spectroscopy in the human brain is one of the more technically advanced applications of human in vivo NMR spectroscopy. Spin/echo techniques introduced reliable localization procedures, whereas the introduction of phase encoding techniques improved the spatial information content considerably. Using the sensitivity of the H-1 NMR signal, a spatial resolution of 7 x 7 x 15 mm can be obtained. Chemical shift images can be reconstructed to represent the choline, creatine, N-acetyl aspartate and lactate distribution in the human brain. These low resolution images may be used as a new functional imaging modality to visualize and derive quantitative biochemical information from focal brain lesions under normal and pathological conditions.

AB - Localized proton NMR spectroscopy in the human brain is one of the more technically advanced applications of human in vivo NMR spectroscopy. Spin/echo techniques introduced reliable localization procedures, whereas the introduction of phase encoding techniques improved the spatial information content considerably. Using the sensitivity of the H-1 NMR signal, a spatial resolution of 7 x 7 x 15 mm can be obtained. Chemical shift images can be reconstructed to represent the choline, creatine, N-acetyl aspartate and lactate distribution in the human brain. These low resolution images may be used as a new functional imaging modality to visualize and derive quantitative biochemical information from focal brain lesions under normal and pathological conditions.

KW - NUCLEAR MAGNETIC-RESONANCE

KW - NMR-SPECTROSCOPY

KW - HUMAN-BRAIN

KW - SELECTIVE EXCITATION

KW - INVIVO SPECTROSCOPY

KW - INTRACRANIAL TUMORS

KW - STIMULATED ECHOES

KW - LOCALIZATION

KW - METABOLITES

KW - INVERSION

M3 - Article

SN - 0952-3480

VL - 4

SP - 64

EP - 69

JO - NMR in Biomedicine

JF - NMR in Biomedicine

IS - 2

ER -

ACQUISITION AND QUANTITATION IN PROTON SPECTROSCOPY

Abstract

Keywords

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