Accuracy of whole-body MRI in the assessment of splenic involvement in lymphoma

Annemieke S Littooij; Thomas C Kwee; Ignasi Barber; Claudio Granata; B de Keizer; Frederik Ja Beek; MGG Hobbelink; Rob Fijnheer; Jaap Stoker; Rutger Jan Nievelstein

doi:10.1177/0284185115571657

Accuracy of whole-body MRI in the assessment of splenic involvement in lymphoma

Annemieke S Littooij, Thomas C Kwee, Ignasi Barber, Claudio Granata, B de Keizer, Frederik Ja Beek, MGG Hobbelink, Rob Fijnheer, Jaap Stoker, Rutger Jan Nievelstein

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Accurate evaluation of the spleen is an important component of staging lymphoma, because this may have prognostic and therapeutic implications.

PURPOSE: To determine the diagnostic value of whole-body magnetic resonance imaging (MRI), including diffusion-weighted imaging (whole-body MRI-DWI) in the detection of splenic involvement in lymphoma.

MATERIAL AND METHODS: This IRB approved, prospective multicenter study included a total of 107 patients with newly diagnosed, histologically proven lymphoma who underwent 1.5 T whole-body MRI-DWI and FDG-PET/CT. Whole-body MRI-DWI and FDG-PET/CT were independently evaluated by a radiologist and a nuclear medicine physician, in a blinded manner. Splenic involvement at MRI was defined as splenic index > 725 cm(3) or discrete nodules. At FDG-PET/CT splenic involvement was defined as splenic uptake greater than liver uptake or hypodense nodules at contrast-enhanced CT. FDG-PET/CT augmented with follow-up imaging after treatment was used as reference standard.

RESULTS: Splenic involvement was detected with FDG-PET/CT in 21 patients, all demonstrating response to treatment. The sensitivity, specificity, positive predictive value, and negative predictive value of whole-body MRI-DWI for the detection of splenic involvement were 85.7 %, 96.5 %, 85.7%, and 96.5%, respectively. Three out of six discrepancies were related to suboptimal criterion of splenic size used with whole-body MRI-DWI versus the size-independent FDG uptake.

CONCLUSION: Whole-body MRI-DWI is reasonably accurate in the detection of splenic lymphomatous involvement.

Original language	English
Journal	Acta Radiologica
DOIs	https://doi.org/10.1177/0284185115571657
Publication status	Published - 13 Feb 2015

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@article{e21a1b31d5c04f4b907a2630fb69fa94,

title = "Accuracy of whole-body MRI in the assessment of splenic involvement in lymphoma",

abstract = "BACKGROUND: Accurate evaluation of the spleen is an important component of staging lymphoma, because this may have prognostic and therapeutic implications.PURPOSE: To determine the diagnostic value of whole-body magnetic resonance imaging (MRI), including diffusion-weighted imaging (whole-body MRI-DWI) in the detection of splenic involvement in lymphoma.MATERIAL AND METHODS: This IRB approved, prospective multicenter study included a total of 107 patients with newly diagnosed, histologically proven lymphoma who underwent 1.5 T whole-body MRI-DWI and FDG-PET/CT. Whole-body MRI-DWI and FDG-PET/CT were independently evaluated by a radiologist and a nuclear medicine physician, in a blinded manner. Splenic involvement at MRI was defined as splenic index > 725 cm(3) or discrete nodules. At FDG-PET/CT splenic involvement was defined as splenic uptake greater than liver uptake or hypodense nodules at contrast-enhanced CT. FDG-PET/CT augmented with follow-up imaging after treatment was used as reference standard.RESULTS: Splenic involvement was detected with FDG-PET/CT in 21 patients, all demonstrating response to treatment. The sensitivity, specificity, positive predictive value, and negative predictive value of whole-body MRI-DWI for the detection of splenic involvement were 85.7 %, 96.5 %, 85.7%, and 96.5%, respectively. Three out of six discrepancies were related to suboptimal criterion of splenic size used with whole-body MRI-DWI versus the size-independent FDG uptake.CONCLUSION: Whole-body MRI-DWI is reasonably accurate in the detection of splenic lymphomatous involvement.",

author = "Littooij, {Annemieke S} and Kwee, {Thomas C} and Ignasi Barber and Claudio Granata and {de Keizer}, B and Beek, {Frederik Ja} and MGG Hobbelink and Rob Fijnheer and Jaap Stoker and Nievelstein, {Rutger Jan}",

note = "{\textcopyright} The Foundation Acta Radiologica 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.",

year = "2015",

month = feb,

day = "13",

doi = "10.1177/0284185115571657",

language = "English",

journal = "Acta Radiologica",

issn = "0284-1851",

publisher = "SAGE Publications Ltd",

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TY - JOUR

T1 - Accuracy of whole-body MRI in the assessment of splenic involvement in lymphoma

AU - Littooij, Annemieke S

AU - Kwee, Thomas C

AU - Barber, Ignasi

AU - Granata, Claudio

AU - de Keizer, B

AU - Beek, Frederik Ja

AU - Hobbelink, MGG

AU - Fijnheer, Rob

AU - Stoker, Jaap

AU - Nievelstein, Rutger Jan

PY - 2015/2/13

Y1 - 2015/2/13

N2 - BACKGROUND: Accurate evaluation of the spleen is an important component of staging lymphoma, because this may have prognostic and therapeutic implications.PURPOSE: To determine the diagnostic value of whole-body magnetic resonance imaging (MRI), including diffusion-weighted imaging (whole-body MRI-DWI) in the detection of splenic involvement in lymphoma.MATERIAL AND METHODS: This IRB approved, prospective multicenter study included a total of 107 patients with newly diagnosed, histologically proven lymphoma who underwent 1.5 T whole-body MRI-DWI and FDG-PET/CT. Whole-body MRI-DWI and FDG-PET/CT were independently evaluated by a radiologist and a nuclear medicine physician, in a blinded manner. Splenic involvement at MRI was defined as splenic index > 725 cm(3) or discrete nodules. At FDG-PET/CT splenic involvement was defined as splenic uptake greater than liver uptake or hypodense nodules at contrast-enhanced CT. FDG-PET/CT augmented with follow-up imaging after treatment was used as reference standard.RESULTS: Splenic involvement was detected with FDG-PET/CT in 21 patients, all demonstrating response to treatment. The sensitivity, specificity, positive predictive value, and negative predictive value of whole-body MRI-DWI for the detection of splenic involvement were 85.7 %, 96.5 %, 85.7%, and 96.5%, respectively. Three out of six discrepancies were related to suboptimal criterion of splenic size used with whole-body MRI-DWI versus the size-independent FDG uptake.CONCLUSION: Whole-body MRI-DWI is reasonably accurate in the detection of splenic lymphomatous involvement.

AB - BACKGROUND: Accurate evaluation of the spleen is an important component of staging lymphoma, because this may have prognostic and therapeutic implications.PURPOSE: To determine the diagnostic value of whole-body magnetic resonance imaging (MRI), including diffusion-weighted imaging (whole-body MRI-DWI) in the detection of splenic involvement in lymphoma.MATERIAL AND METHODS: This IRB approved, prospective multicenter study included a total of 107 patients with newly diagnosed, histologically proven lymphoma who underwent 1.5 T whole-body MRI-DWI and FDG-PET/CT. Whole-body MRI-DWI and FDG-PET/CT were independently evaluated by a radiologist and a nuclear medicine physician, in a blinded manner. Splenic involvement at MRI was defined as splenic index > 725 cm(3) or discrete nodules. At FDG-PET/CT splenic involvement was defined as splenic uptake greater than liver uptake or hypodense nodules at contrast-enhanced CT. FDG-PET/CT augmented with follow-up imaging after treatment was used as reference standard.RESULTS: Splenic involvement was detected with FDG-PET/CT in 21 patients, all demonstrating response to treatment. The sensitivity, specificity, positive predictive value, and negative predictive value of whole-body MRI-DWI for the detection of splenic involvement were 85.7 %, 96.5 %, 85.7%, and 96.5%, respectively. Three out of six discrepancies were related to suboptimal criterion of splenic size used with whole-body MRI-DWI versus the size-independent FDG uptake.CONCLUSION: Whole-body MRI-DWI is reasonably accurate in the detection of splenic lymphomatous involvement.

U2 - 10.1177/0284185115571657

DO - 10.1177/0284185115571657

M3 - Article

C2 - 25681490

SN - 0284-1851

JO - Acta Radiologica

JF - Acta Radiologica

ER -

Accuracy of whole-body MRI in the assessment of splenic involvement in lymphoma

Abstract

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