Accuracy of 18F-FDG PET/CT for primary tumor visualization and staging in T1 breast cancer

Bas B Koolen; Femke van der Leij; Wouter V Vogel; Emiel J Th Rutgers; Marie-Jeanne T F D Vrancken Peeters; Paula H M Elkhuizen; Renato A Valdés Olmos

doi:10.3109/0284186X.2013.783714

Accuracy of 18F-FDG PET/CT for primary tumor visualization and staging in T1 breast cancer

Bas B Koolen^*, Femke van der Leij, Wouter V Vogel, Emiel J Th Rutgers, Marie-Jeanne T F D Vrancken Peeters, Paula H M Elkhuizen, Renato A Valdés Olmos

^*Corresponding author for this work

Cancer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: The aim of this study was to assess the accuracy of 18F-FDG PET/CT in T1 breast cancer regarding visualization of the primary tumor and the detection of locoregional and distant metastases.

METHODS: Sixty-two women with invasive T1 breast cancer underwent a PET/CT. Image acquisition of the thorax was done in prone position with hanging breasts, followed by whole-body scanning in supine position. Primary tumor FDG uptake was evaluated and compared with clinical and histopathological characteristics. Presence of locoregional and distant metastases was assessed and compared with conventional imaging procedures.

RESULTS: The primary tumor was visible with PET/CT in 54 (87%) of 62 patients, increasing from 59% (10/17) in tumors ≤ 10 mm to 98% (44/45) in tumors over 10 mm. All triple negative and HER2-positive tumors and 40/48 (83%) ER-positive/HER2-negative tumors were visualized. Sensitivity and specificity of PET/CT in the detection of axillary metastases were 73% and 100%, respectively. PET/CT depicted periclavicular nodes in two patients. Of 12 distant lesions, one was confirmed to be a lung metastasis, three were false positive, and eight were new primary proliferative lesions.

CONCLUSION: Using optimal imaging acquisition, the majority of T1 breast carcinomas can be visualized with PET/CT. Specificity in the detection of axillary metastases is excellent, but sensitivity appears to be limited. Additional whole body imaging has a low yield in this specific patient group.

Original language	English
Pages (from-to)	50-7
Number of pages	8
Journal	Acta Oncologica
Volume	53
Issue number	1
DOIs	https://doi.org/10.3109/0284186X.2013.783714
Publication status	Published - Jan 2014

Keywords

Aged
Breast Neoplasms/diagnostic imaging
Carcinoma, Ductal, Breast/diagnostic imaging
Carcinoma, Lobular/diagnostic imaging
Female
Fluorodeoxyglucose F18
Follow-Up Studies
Humans
Lymphatic Metastasis
Middle Aged
Multimodal Imaging
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Staging
Positron-Emission Tomography
Prognosis
Radiopharmaceuticals
Sensitivity and Specificity
Tomography, X-Ray Computed

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10.3109/0284186X.2013.783714

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@article{f7dbd722b99c48f3b5de9257c16d0874,

title = "Accuracy of 18F-FDG PET/CT for primary tumor visualization and staging in T1 breast cancer",

abstract = "BACKGROUND: The aim of this study was to assess the accuracy of 18F-FDG PET/CT in T1 breast cancer regarding visualization of the primary tumor and the detection of locoregional and distant metastases.METHODS: Sixty-two women with invasive T1 breast cancer underwent a PET/CT. Image acquisition of the thorax was done in prone position with hanging breasts, followed by whole-body scanning in supine position. Primary tumor FDG uptake was evaluated and compared with clinical and histopathological characteristics. Presence of locoregional and distant metastases was assessed and compared with conventional imaging procedures.RESULTS: The primary tumor was visible with PET/CT in 54 (87%) of 62 patients, increasing from 59% (10/17) in tumors ≤ 10 mm to 98% (44/45) in tumors over 10 mm. All triple negative and HER2-positive tumors and 40/48 (83%) ER-positive/HER2-negative tumors were visualized. Sensitivity and specificity of PET/CT in the detection of axillary metastases were 73% and 100%, respectively. PET/CT depicted periclavicular nodes in two patients. Of 12 distant lesions, one was confirmed to be a lung metastasis, three were false positive, and eight were new primary proliferative lesions.CONCLUSION: Using optimal imaging acquisition, the majority of T1 breast carcinomas can be visualized with PET/CT. Specificity in the detection of axillary metastases is excellent, but sensitivity appears to be limited. Additional whole body imaging has a low yield in this specific patient group.",

keywords = "Aged, Breast Neoplasms/diagnostic imaging, Carcinoma, Ductal, Breast/diagnostic imaging, Carcinoma, Lobular/diagnostic imaging, Female, Fluorodeoxyglucose F18, Follow-Up Studies, Humans, Lymphatic Metastasis, Middle Aged, Multimodal Imaging, Neoplasm Grading, Neoplasm Invasiveness, Neoplasm Staging, Positron-Emission Tomography, Prognosis, Radiopharmaceuticals, Sensitivity and Specificity, Tomography, X-Ray Computed",

author = "Koolen, {Bas B} and {van der Leij}, Femke and Vogel, {Wouter V} and Rutgers, {Emiel J Th} and {Vrancken Peeters}, {Marie-Jeanne T F D} and Elkhuizen, {Paula H M} and {Vald{\'e}s Olmos}, {Renato A}",

year = "2014",

month = jan,

doi = "10.3109/0284186X.2013.783714",

language = "English",

volume = "53",

pages = "50--7",

journal = "Acta Oncologica",

issn = "0284-186X",

publisher = "Informa Healthcare",

number = "1",

}

TY - JOUR

T1 - Accuracy of 18F-FDG PET/CT for primary tumor visualization and staging in T1 breast cancer

AU - Koolen, Bas B

AU - van der Leij, Femke

AU - Vogel, Wouter V

AU - Rutgers, Emiel J Th

AU - Vrancken Peeters, Marie-Jeanne T F D

AU - Elkhuizen, Paula H M

AU - Valdés Olmos, Renato A

PY - 2014/1

Y1 - 2014/1

N2 - BACKGROUND: The aim of this study was to assess the accuracy of 18F-FDG PET/CT in T1 breast cancer regarding visualization of the primary tumor and the detection of locoregional and distant metastases.METHODS: Sixty-two women with invasive T1 breast cancer underwent a PET/CT. Image acquisition of the thorax was done in prone position with hanging breasts, followed by whole-body scanning in supine position. Primary tumor FDG uptake was evaluated and compared with clinical and histopathological characteristics. Presence of locoregional and distant metastases was assessed and compared with conventional imaging procedures.RESULTS: The primary tumor was visible with PET/CT in 54 (87%) of 62 patients, increasing from 59% (10/17) in tumors ≤ 10 mm to 98% (44/45) in tumors over 10 mm. All triple negative and HER2-positive tumors and 40/48 (83%) ER-positive/HER2-negative tumors were visualized. Sensitivity and specificity of PET/CT in the detection of axillary metastases were 73% and 100%, respectively. PET/CT depicted periclavicular nodes in two patients. Of 12 distant lesions, one was confirmed to be a lung metastasis, three were false positive, and eight were new primary proliferative lesions.CONCLUSION: Using optimal imaging acquisition, the majority of T1 breast carcinomas can be visualized with PET/CT. Specificity in the detection of axillary metastases is excellent, but sensitivity appears to be limited. Additional whole body imaging has a low yield in this specific patient group.

AB - BACKGROUND: The aim of this study was to assess the accuracy of 18F-FDG PET/CT in T1 breast cancer regarding visualization of the primary tumor and the detection of locoregional and distant metastases.METHODS: Sixty-two women with invasive T1 breast cancer underwent a PET/CT. Image acquisition of the thorax was done in prone position with hanging breasts, followed by whole-body scanning in supine position. Primary tumor FDG uptake was evaluated and compared with clinical and histopathological characteristics. Presence of locoregional and distant metastases was assessed and compared with conventional imaging procedures.RESULTS: The primary tumor was visible with PET/CT in 54 (87%) of 62 patients, increasing from 59% (10/17) in tumors ≤ 10 mm to 98% (44/45) in tumors over 10 mm. All triple negative and HER2-positive tumors and 40/48 (83%) ER-positive/HER2-negative tumors were visualized. Sensitivity and specificity of PET/CT in the detection of axillary metastases were 73% and 100%, respectively. PET/CT depicted periclavicular nodes in two patients. Of 12 distant lesions, one was confirmed to be a lung metastasis, three were false positive, and eight were new primary proliferative lesions.CONCLUSION: Using optimal imaging acquisition, the majority of T1 breast carcinomas can be visualized with PET/CT. Specificity in the detection of axillary metastases is excellent, but sensitivity appears to be limited. Additional whole body imaging has a low yield in this specific patient group.

KW - Aged

KW - Breast Neoplasms/diagnostic imaging

KW - Carcinoma, Ductal, Breast/diagnostic imaging

KW - Carcinoma, Lobular/diagnostic imaging

KW - Female

KW - Fluorodeoxyglucose F18

KW - Follow-Up Studies

KW - Humans

KW - Lymphatic Metastasis

KW - Middle Aged

KW - Multimodal Imaging

KW - Neoplasm Grading

KW - Neoplasm Invasiveness

KW - Neoplasm Staging

KW - Positron-Emission Tomography

KW - Prognosis

KW - Radiopharmaceuticals

KW - Sensitivity and Specificity

KW - Tomography, X-Ray Computed

U2 - 10.3109/0284186X.2013.783714

DO - 10.3109/0284186X.2013.783714

M3 - Article

C2 - 23672678

SN - 0284-186X

VL - 53

SP - 50

EP - 57

JO - Acta Oncologica

JF - Acta Oncologica

IS - 1

ER -

Accuracy of 18F-FDG PET/CT for primary tumor visualization and staging in T1 breast cancer

Abstract

Keywords

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