Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders

Tatiana Oviedo-Salcedo*, Lot De Witte, Tania Kümpfel, René S. Kahn, Peter Falkai, Peter Eichhorn, Jurjen Luykx, Alkomiet Hasan

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Antibody-mediated encephalitis has been discussed as one possible cause for isolated psychotic syndromes. Mostly based on serum samples, findings have been controversial. We present the results of a retrospective study of 124 clinically diagnosed psychotic patients without documented relevant neurological symptoms. All were tested for different antineuronal antibodies in cerebrospinal fluid (CSF) while 81 received serum testing. Antineuronal antibodies in CSF were negative across the sample. 3.7% showed low positive serum antibodies. Our findings highlight the importance of a deeper discussion about the relevance of low positive serum antibodies without concurrent findings in CSF or clinical signs for autoimmune encephalitis.

Original languageEnglish
Pages (from-to)318-320
Number of pages3
JournalBritish Journal of Psychiatry
Issue number5
Publication statusPublished - 1 May 2018


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