TY - JOUR
T1 - Absence of association between whole blood viscosity and delirium after cardiac surgery
T2 - A case-controlled study
AU - CheheiliSobbi, Shokoufeh
AU - van den Boogaard, Mark
AU - Slooter, Arjen J C
AU - van Swieten, Henry A.
AU - Ceelen, Linda
AU - Pop, Gheorghe
AU - Abdo, Wilson F.
AU - Pickkers, Peter
PY - 2016/8/5
Y1 - 2016/8/5
N2 - Background: Delirium after cardiothoracic surgery is common and associated with impaired outcomes. Although several mechanisms have been proposed (including changes in cerebral perfusion), the pathophysiology of postoperative delirium remains unclear. Blood viscosity is related to cerebral perfusion and thereby might contribute to the development of delirium after cardiothoracic surgery. The aim of this study was to investigate whether whole blood viscosity differs between cardiothoracic surgery patients with and without delirium. Methods: In this observational study postoperative whole blood viscosity of patients that developed delirium (cases) were compared with non-delirious cardiothoracic surgery patients (controls). Cases were matched with the controls, yielding a 1:4 case-control study. Serial hematocrit, fibrinogen, and whole blood viscosity were determined pre-operatively and at each postoperative day. Delirium was assessed using the validated Confusion Assessment Method for the Intensive Care Unit or Delirium Screening Observation scale. Results: In total 80 cardiothoracic surgery patients were screened of whom 12 delirious and 48 matched non-delirious patients were included. No significant difference was found between both groups in fibrinogen (p = 0.36), hematocrit (p = 0.23) and the area under curve of the whole blood viscosity between shear rates 0.02 and 50 s-1 (p = 0.80) or between shear rates 0.02 and 5 s-1 (p = 0.78). Conclusion: In this case control study in cardiothoracic surgery patients changes in whole blood viscosity were not associated with the development of delirium.
AB - Background: Delirium after cardiothoracic surgery is common and associated with impaired outcomes. Although several mechanisms have been proposed (including changes in cerebral perfusion), the pathophysiology of postoperative delirium remains unclear. Blood viscosity is related to cerebral perfusion and thereby might contribute to the development of delirium after cardiothoracic surgery. The aim of this study was to investigate whether whole blood viscosity differs between cardiothoracic surgery patients with and without delirium. Methods: In this observational study postoperative whole blood viscosity of patients that developed delirium (cases) were compared with non-delirious cardiothoracic surgery patients (controls). Cases were matched with the controls, yielding a 1:4 case-control study. Serial hematocrit, fibrinogen, and whole blood viscosity were determined pre-operatively and at each postoperative day. Delirium was assessed using the validated Confusion Assessment Method for the Intensive Care Unit or Delirium Screening Observation scale. Results: In total 80 cardiothoracic surgery patients were screened of whom 12 delirious and 48 matched non-delirious patients were included. No significant difference was found between both groups in fibrinogen (p = 0.36), hematocrit (p = 0.23) and the area under curve of the whole blood viscosity between shear rates 0.02 and 50 s-1 (p = 0.80) or between shear rates 0.02 and 5 s-1 (p = 0.78). Conclusion: In this case control study in cardiothoracic surgery patients changes in whole blood viscosity were not associated with the development of delirium.
KW - Cardiothoracic surgery
KW - Delirium
KW - Intensive care
KW - Medicine
KW - Whole blood viscosity
UR - http://www.scopus.com/inward/record.url?scp=84980649342&partnerID=8YFLogxK
U2 - 10.1186/s13019-016-0517-9
DO - 10.1186/s13019-016-0517-9
M3 - Article
C2 - 27495293
AN - SCOPUS:84980649342
SN - 1749-8090
VL - 11
JO - Journal of Cardiothoracic Surgery [E]
JF - Journal of Cardiothoracic Surgery [E]
IS - 1
M1 - 132
ER -