Abnormalities of Cerebral Deep Medullary Veins on 7 Tesla MRI in Amnestic Mild Cognitive Impairment and Early Alzheimer's Disease: A Pilot Study

Willem H Bouvy; Hugo J Kuijf; Jaco J M Zwanenburg; Huiberdina L Koek; L Jaap Kappelle; Peter R Luijten; M Kamran Ikram; Geert Jan Biessels

doi:10.3233/JAD-160952

Abnormalities of Cerebral Deep Medullary Veins on 7 Tesla MRI in Amnestic Mild Cognitive Impairment and Early Alzheimer's Disease: A Pilot Study

Willem H Bouvy, Hugo J Kuijf, Jaco J M Zwanenburg, Huiberdina L Koek, L Jaap Kappelle, Peter R Luijten, M Kamran Ikram, Geert Jan Biessels^*,

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Cerebral small vessel disease (SVD) contributes to cognitive impairment and dementia. SVD may affect veins, but veins are difficult to detect with 1.5 and 3T MRI. We compared deep medullary veins (DMVs) visualized on 7T-MRI between patients with early Alzheimer's disease (eAD; n = 17) or amnestic MCI (aMCI; n = 12) and controls (n = 40). The number and density of DMVs was similar in patients and controls, but tortuosity was higher in eAD (Cohen's d=0.7, 95% CI: 0.1-1.2, p=0.02) and aMCI (Cohen's d = 0.8, 95% CI: 0.2-1.5, p = 0.01), independent of brain atrophy. Venous changes provide a new perspective on vascular involvement in dementia.

Original language	English
Pages (from-to)	705-710
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	57
Issue number	3
DOIs	https://doi.org/10.3233/JAD-160952
Publication status	Published - 2017

Keywords

Alzheimer's disease
cerebral small vessel disease
cerebral veins
magnetic resonance imaging

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10.3233/JAD-160952

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title = "Abnormalities of Cerebral Deep Medullary Veins on 7 Tesla MRI in Amnestic Mild Cognitive Impairment and Early Alzheimer's Disease: A Pilot Study",

abstract = "Cerebral small vessel disease (SVD) contributes to cognitive impairment and dementia. SVD may affect veins, but veins are difficult to detect with 1.5 and 3T MRI. We compared deep medullary veins (DMVs) visualized on 7T-MRI between patients with early Alzheimer's disease (eAD; n = 17) or amnestic MCI (aMCI; n = 12) and controls (n = 40). The number and density of DMVs was similar in patients and controls, but tortuosity was higher in eAD (Cohen's d=0.7, 95% CI: 0.1-1.2, p=0.02) and aMCI (Cohen's d = 0.8, 95% CI: 0.2-1.5, p = 0.01), independent of brain atrophy. Venous changes provide a new perspective on vascular involvement in dementia.",

keywords = "Alzheimer's disease, cerebral small vessel disease, cerebral veins, magnetic resonance imaging",

author = "Bouvy, {Willem H} and Kuijf, {Hugo J} and Zwanenburg, {Jaco J M} and Koek, {Huiberdina L} and Kappelle, {L Jaap} and Luijten, {Peter R} and Ikram, {M Kamran} and Biessels, {Geert Jan}",

year = "2017",

doi = "10.3233/JAD-160952",

language = "English",

volume = "57",

pages = "705--710",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "IOS Press",

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TY - JOUR

T1 - Abnormalities of Cerebral Deep Medullary Veins on 7 Tesla MRI in Amnestic Mild Cognitive Impairment and Early Alzheimer's Disease

T2 - A Pilot Study

AU - Bouvy, Willem H

AU - Kuijf, Hugo J

AU - Zwanenburg, Jaco J M

AU - Koek, Huiberdina L

AU - Kappelle, L Jaap

AU - Luijten, Peter R

AU - Ikram, M Kamran

AU - Biessels, Geert Jan

PY - 2017

Y1 - 2017

N2 - Cerebral small vessel disease (SVD) contributes to cognitive impairment and dementia. SVD may affect veins, but veins are difficult to detect with 1.5 and 3T MRI. We compared deep medullary veins (DMVs) visualized on 7T-MRI between patients with early Alzheimer's disease (eAD; n = 17) or amnestic MCI (aMCI; n = 12) and controls (n = 40). The number and density of DMVs was similar in patients and controls, but tortuosity was higher in eAD (Cohen's d=0.7, 95% CI: 0.1-1.2, p=0.02) and aMCI (Cohen's d = 0.8, 95% CI: 0.2-1.5, p = 0.01), independent of brain atrophy. Venous changes provide a new perspective on vascular involvement in dementia.

AB - Cerebral small vessel disease (SVD) contributes to cognitive impairment and dementia. SVD may affect veins, but veins are difficult to detect with 1.5 and 3T MRI. We compared deep medullary veins (DMVs) visualized on 7T-MRI between patients with early Alzheimer's disease (eAD; n = 17) or amnestic MCI (aMCI; n = 12) and controls (n = 40). The number and density of DMVs was similar in patients and controls, but tortuosity was higher in eAD (Cohen's d=0.7, 95% CI: 0.1-1.2, p=0.02) and aMCI (Cohen's d = 0.8, 95% CI: 0.2-1.5, p = 0.01), independent of brain atrophy. Venous changes provide a new perspective on vascular involvement in dementia.

KW - Alzheimer's disease

KW - cerebral small vessel disease

KW - cerebral veins

KW - magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=85017529176&partnerID=8YFLogxK

U2 - 10.3233/JAD-160952

DO - 10.3233/JAD-160952

M3 - Article

C2 - 28282806

SN - 1387-2877

VL - 57

SP - 705

EP - 710

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 3

ER -

Abnormalities of Cerebral Deep Medullary Veins on 7 Tesla MRI in Amnestic Mild Cognitive Impairment and Early Alzheimer's Disease: A Pilot Study

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Keywords

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