A Unified Nomenclature and Amino Acid Numbering for Human PTEN

Rafael Pulido; Suzanne J. Baker; Joao T. Barata; Arkaitz Carracedo; Victor J. Cid; Ian D. Chin-Sang; Vrushank Dave; J. den Hertog; Peter Devreotes; Britta J. Eickholt; Charis Eng; Frank B. Furnari; Maria Magdalena Georgescu; Arne Gericke; Benjamin Hopkins; Xeujun Jiang; Seung Rock Lee; Mathias Loesche; Prerna Malaney; Xavier Matias-Guiu; Maria Molina; Pier Paolo Pandolfi; Ramon Parsons; Paolo Pinton; Carmen Rivas; Rafael M. Rocha; Manuel S. Rodriguez; Alonzo H. Ross; Manuel Serrano; Vuk Stambolic; Bangyan Stiles; Akira Suzuki; Seong Seng Tan; Nicholas K. Tonks; Lloyd C. Trotman; Nicolas Wolff; Rudiger Woscholski; W. Wu; Nicholas R. Leslie

A Unified Nomenclature and Amino Acid Numbering for Human PTEN

Translated title of the contribution: A Unified Nomenclature and Amino Acid Numbering for Human PTEN

Rafael Pulido, Suzanne J. Baker, Joao T. Barata, Arkaitz Carracedo, Victor J. Cid, Ian D. Chin-Sang, Vrushank Dave, J. den Hertog, Peter Devreotes, Britta J. Eickholt, Charis Eng, Frank B. Furnari, Maria Magdalena Georgescu, Arne Gericke, Benjamin Hopkins, Xeujun Jiang, Seung Rock Lee, Mathias Loesche, Prerna Malaney, Xavier Matias-GuiuMaria Molina, Pier Paolo Pandolfi, Ramon Parsons, Paolo Pinton, Carmen Rivas, Rafael M. Rocha, Manuel S. Rodriguez, Alonzo H. Ross, Manuel Serrano, Vuk Stambolic, Bangyan Stiles, Akira Suzuki, Seong Seng Tan, Nicholas K. Tonks, Lloyd C. Trotman, Nicolas Wolff, Rudiger Woscholski, W. Wu, Nicholas R. Leslie

Cancer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P-3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN

Translated title of the contribution	A Unified Nomenclature and Amino Acid Numbering for Human PTEN
Original language	Undefined/Unknown
Pages (from-to)	pe15
Number of pages	1
Journal	Science Signaling
Volume	7
Issue number	332
Publication status	Published - 2014

Keywords

Specialized histories (international relations, law)
Literary theory, analysis and criticism
Culturele activiteiten
Overig maatschappelijk onderzoek

Cite this

Pulido, R., Baker, S. J., Barata, J. T., Carracedo, A., Cid, V. J., Chin-Sang, I. D., Dave, V., den Hertog, J., Devreotes, P., Eickholt, B. J., Eng, C., Furnari, F. B., Georgescu, M. M., Gericke, A., Hopkins, B., Jiang, X., Lee, S. R., Loesche, M., Malaney, P., ... Leslie, N. R. (2014). A Unified Nomenclature and Amino Acid Numbering for Human PTEN. Science Signaling, 7(332), pe15.

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title = "A Unified Nomenclature and Amino Acid Numbering for Human PTEN",

abstract = "The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P-3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN",

keywords = "Specialized histories (international relations, law), Literary theory, analysis and criticism, Culturele activiteiten, Overig maatschappelijk onderzoek",

author = "Rafael Pulido and Baker, {Suzanne J.} and Barata, {Joao T.} and Arkaitz Carracedo and Cid, {Victor J.} and Chin-Sang, {Ian D.} and Vrushank Dave and {den Hertog}, J. and Peter Devreotes and Eickholt, {Britta J.} and Charis Eng and Furnari, {Frank B.} and Georgescu, {Maria Magdalena} and Arne Gericke and Benjamin Hopkins and Xeujun Jiang and Lee, {Seung Rock} and Mathias Loesche and Prerna Malaney and Xavier Matias-Guiu and Maria Molina and Pandolfi, {Pier Paolo} and Ramon Parsons and Paolo Pinton and Carmen Rivas and Rocha, {Rafael M.} and Rodriguez, {Manuel S.} and Ross, {Alonzo H.} and Manuel Serrano and Vuk Stambolic and Bangyan Stiles and Akira Suzuki and Tan, {Seong Seng} and Tonks, {Nicholas K.} and Trotman, {Lloyd C.} and Nicolas Wolff and Rudiger Woscholski and W. Wu and Leslie, {Nicholas R.}",

note = "J UL 1 2014",

year = "2014",

language = "Undefined/Unknown",

volume = "7",

pages = "pe15",

journal = "Science Signaling",

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Pulido, R, Baker, SJ, Barata, JT, Carracedo, A, Cid, VJ, Chin-Sang, ID, Dave, V, den Hertog, J, Devreotes, P, Eickholt, BJ, Eng, C, Furnari, FB, Georgescu, MM, Gericke, A, Hopkins, B, Jiang, X, Lee, SR, Loesche, M, Malaney, P, Matias-Guiu, X, Molina, M, Pandolfi, PP, Parsons, R, Pinton, P, Rivas, C, Rocha, RM, Rodriguez, MS, Ross, AH, Serrano, M, Stambolic, V, Stiles, B, Suzuki, A, Tan, SS, Tonks, NK, Trotman, LC, Wolff, N, Woscholski, R, Wu, W & Leslie, NR 2014, 'A Unified Nomenclature and Amino Acid Numbering for Human PTEN', Science Signaling, vol. 7, no. 332, pp. pe15.

TY - JOUR

T1 - A Unified Nomenclature and Amino Acid Numbering for Human PTEN

AU - Pulido, Rafael

AU - Baker, Suzanne J.

AU - Barata, Joao T.

AU - Carracedo, Arkaitz

AU - Cid, Victor J.

AU - Chin-Sang, Ian D.

AU - Dave, Vrushank

AU - den Hertog, J.

AU - Devreotes, Peter

AU - Eickholt, Britta J.

AU - Eng, Charis

AU - Furnari, Frank B.

AU - Georgescu, Maria Magdalena

AU - Gericke, Arne

AU - Hopkins, Benjamin

AU - Jiang, Xeujun

AU - Lee, Seung Rock

AU - Loesche, Mathias

AU - Malaney, Prerna

AU - Matias-Guiu, Xavier

AU - Molina, Maria

AU - Pandolfi, Pier Paolo

AU - Parsons, Ramon

AU - Pinton, Paolo

AU - Rivas, Carmen

AU - Rocha, Rafael M.

AU - Rodriguez, Manuel S.

AU - Ross, Alonzo H.

AU - Serrano, Manuel

AU - Stambolic, Vuk

AU - Stiles, Bangyan

AU - Suzuki, Akira

AU - Tan, Seong Seng

AU - Tonks, Nicholas K.

AU - Trotman, Lloyd C.

AU - Wolff, Nicolas

AU - Woscholski, Rudiger

AU - Wu, W.

AU - Leslie, Nicholas R.

N1 - J UL 1 2014

PY - 2014

Y1 - 2014

N2 - The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P-3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN

AB - The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P-3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN

KW - Specialized histories (international relations, law)

KW - Literary theory, analysis and criticism

KW - Culturele activiteiten

KW - Overig maatschappelijk onderzoek

M3 - Article

SN - 1945-0877

VL - 7

SP - pe15

JO - Science Signaling

JF - Science Signaling

IS - 332

ER -

A Unified Nomenclature and Amino Acid Numbering for Human PTEN

Abstract

Keywords

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