TY - JOUR
T1 - A systematic review on brain injury and altered brain development in moderate-late preterm infants
AU - Boswinkel, Vivian
AU - Nijboer-Oosterveld, Jacqueline
AU - Nijholt, Ingrid M
AU - Edens, Mireille A
AU - Mulder-de Tollenaer, Susanne M
AU - Boomsma, Martijn F
AU - de Vries, Linda S
AU - van Wezel-Meijler, Gerda
N1 - Funding Information:
V. Boswinkel is supported by a grant of the Innovation and Science foundation of Isala (Isala Hospital, Zwolle, the Netherlands) . The other authors received no funding.
Publisher Copyright:
© 2020 Elsevier B.V.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/9
Y1 - 2020/9
N2 - OBJECTIVES: To provide a systematic review of brain injury and altered brain development in moderate-late preterm (MLPT) infants as compared to very preterm and term infants.STUDY DESIGN: A systematic search in five databases was performed in January 2020. Original research papers on incidence of brain injury and papers using quantitative data on brain development in MLPT infants were selected. The Johanna Briggs Institute 'Critical Appraisal Checklist for Studies Reporting Prevalence Data' was used for quality appraisal. Data extraction included: imaging modality, incidences of brain injury, brain volumes, 2D-measurements and diffusivity values.RESULTS: In total, 24 studies were eligible. Most studies had a moderate quality. Twenty studies reported on the incidence of brain injury in MLPT infants. The incidence of intraventricular hemorrhage (IVH) ranged from 0.0% to 23.5% and of white matter injury (WMI) from 0.5% to 10.8%. One study reported the incidence of arterial infarction (0.3%) and none of cerebellar hemorrhage. Eleven studies compared incidences of brain injury between MLPT infants and very preterm or term infants. Five studies reported signs of altered brain development in MLPT infants.CONCLUSIONS: The incidences of IVH and WMI in MLPT infants varied widely between studies. Other abnormalities were sparsely reported. Evidence regarding a higher or lower incidence of brain injury in MLPT infants compared to very preterm or term infants is weak due to moderate methodological quality of reported studies. There is limited evidence suggesting a difference in brain development between MLPT and term infants.
AB - OBJECTIVES: To provide a systematic review of brain injury and altered brain development in moderate-late preterm (MLPT) infants as compared to very preterm and term infants.STUDY DESIGN: A systematic search in five databases was performed in January 2020. Original research papers on incidence of brain injury and papers using quantitative data on brain development in MLPT infants were selected. The Johanna Briggs Institute 'Critical Appraisal Checklist for Studies Reporting Prevalence Data' was used for quality appraisal. Data extraction included: imaging modality, incidences of brain injury, brain volumes, 2D-measurements and diffusivity values.RESULTS: In total, 24 studies were eligible. Most studies had a moderate quality. Twenty studies reported on the incidence of brain injury in MLPT infants. The incidence of intraventricular hemorrhage (IVH) ranged from 0.0% to 23.5% and of white matter injury (WMI) from 0.5% to 10.8%. One study reported the incidence of arterial infarction (0.3%) and none of cerebellar hemorrhage. Eleven studies compared incidences of brain injury between MLPT infants and very preterm or term infants. Five studies reported signs of altered brain development in MLPT infants.CONCLUSIONS: The incidences of IVH and WMI in MLPT infants varied widely between studies. Other abnormalities were sparsely reported. Evidence regarding a higher or lower incidence of brain injury in MLPT infants compared to very preterm or term infants is weak due to moderate methodological quality of reported studies. There is limited evidence suggesting a difference in brain development between MLPT and term infants.
KW - Brain imaging
KW - Brain injury
KW - Intraventricular hemorrhage
KW - Moderate-late preterm infants
UR - http://www.scopus.com/inward/record.url?scp=85088221053&partnerID=8YFLogxK
U2 - 10.1016/j.earlhumdev.2020.105094
DO - 10.1016/j.earlhumdev.2020.105094
M3 - Review article
C2 - 32711341
SN - 0378-3782
VL - 148
SP - 105094
JO - Early Human Development
JF - Early Human Development
M1 - 105094
ER -