A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe

B T Baune; S E Fromme; M Aberg; M Adli; A Afantitis; I Akkouh; O A Andreassen; C Angulo; S Barlati; C Brasso; P Bucci; M Budde; P Buspavanich; V Cavone; K Demyttenaere; C M Diaz-Caneja; M Dierssen; S Djurovic; M Driessen; U W Ebner-Priemer; J Engelmann; S Englisch; C Fabbri; P Fossati; H Fröhlich; S Gasser; N Gottlieb; E Heirman; A Hofer; O Howes; L Ilzarbe; H Jeung-Maarse; L V Kessing; T D Kockler; M Landén; L Levi; K Lieb; N Lorenzon; J Luykx; M Manchia; M Martinez de Lagran; A Minelli; C Moreno; A Mucci; B Müller-Myhsok; P Nilsson; C Okhuijsen-Pfeifer; K D Papavasileiou; S Papiol; A F Pardinas; P Paribello; C Pisanu; M-C Potier; A Reif; R Ricken; S Ripke; P Rocca; D Scherrer; C Schiweck; K O Schubert; T G Schulze; A Serretti; A Squassina; C Stephan; A Tsoumanis; E Van der Eycken; E Vieta; A Vita; J T R Walters; D Weichert; M Weiser; I R Willcocks; I Winter-van Rossum; A H Young; M J Ziller

doi:10.1007/s00406-024-01944-3

A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe

B T Baune^*
, S E Fromme
, M Aberg
, M Adli
, A Afantitis
, I Akkouh
, O A Andreassen
, C Angulo
, S Barlati
, C Brasso
, P Bucci
, M Budde
, P Buspavanich
, V Cavone
, K Demyttenaere
, C M Diaz-Caneja
, M Dierssen
, S Djurovic
, M Driessen
, U W Ebner-Priemer

J Engelmann, S Englisch, C Fabbri, P Fossati, H Fröhlich, S Gasser, N Gottlieb, E Heirman, A Hofer, O Howes, L Ilzarbe, H Jeung-Maarse, L V Kessing, T D Kockler, M Landén, L Levi, K Lieb, N Lorenzon, J Luykx, M Manchia, M Martinez de Lagran, A Minelli, C Moreno, A Mucci, B Müller-Myhsok, P Nilsson, C Okhuijsen-Pfeifer, K D Papavasileiou, S Papiol, A F Pardinas, P Paribello, C Pisanu, M-C Potier, A Reif, R Ricken, S Ripke, P Rocca, D Scherrer, C Schiweck, K O Schubert, T G Schulze, A Serretti, A Squassina, C Stephan, A Tsoumanis, E Van der Eycken, E Vieta, A Vita, J T R Walters, D Weichert, M Weiser, I R Willcocks, I Winter-van Rossum, A H Young, M J Ziller

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Schizophrenia (SCZ), bipolar (BD) and major depression disorder (MDD) are severe psychiatric disorders that are challenging to treat, often leading to treatment resistance (TR). It is crucial to develop effective methods to identify and treat patients at risk of TR at an early stage in a personalized manner, considering their biological basis, their clinical and psychosocial characteristics. Effective translation of theoretical knowledge into clinical practice is essential for achieving this goal. The Psych-STRATA consortium addresses this research gap through a seven-step approach. First, transdiagnostic biosignatures of SCZ, BD and MDD are identified by GWAS and multi-modal omics signatures associated with treatment outcome and TR (steps 1 and 2). In a next step (step 3), a randomized controlled intervention study is conducted to test the efficacy and safety of an early intensified pharmacological treatment. Following this RCT, a combined clinical and omics-based algorithm will be developed to estimate the risk for TR. This algorithm-based tool will be designed for early detection and management of TR (step 4). This algorithm will then be implemented into a framework of shared treatment decision-making with a novel mental health board (step 5). The final focus of the project is based on patient empowerment, dissemination and education (step 6) as well as the development of a software for fast, effective and individualized treatment decisions (step 7). The project has the potential to change the current trial and error treatment approach towards an evidence-based individualized treatment setting that takes TR risk into account at an early stage.

Original language	English
Pages (from-to)	1453-1464
Number of pages	12
Journal	European Archives of Psychiatry and Clinical Neuroscience
Volume	275
Issue number	5
Early online date	27 Dec 2024
DOIs	https://doi.org/10.1007/s00406-024-01944-3
Publication status	Published - Aug 2025

Keywords

Depression schizophrenia
Early detection
Early treatment
Precision psychiatry
Treatment resistance

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Baune, B. T., Fromme, S. E., Aberg, M., Adli, M., Afantitis, A., Akkouh, I., Andreassen, O. A., Angulo, C., Barlati, S., Brasso, C., Bucci, P., Budde, M., Buspavanich, P., Cavone, V., Demyttenaere, K., Diaz-Caneja, C. M., Dierssen, M., Djurovic, S., Driessen, M., ... Ziller, M. J. (2025). A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe. European Archives of Psychiatry and Clinical Neuroscience, 275(5), 1453-1464. https://doi.org/10.1007/s00406-024-01944-3

Baune, B T ; Fromme, S E ; Aberg, M et al. / A stratified treatment algorithm in psychiatry : a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe. In: European Archives of Psychiatry and Clinical Neuroscience. 2025 ; Vol. 275, No. 5. pp. 1453-1464.

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title = "A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe",

abstract = "Schizophrenia (SCZ), bipolar (BD) and major depression disorder (MDD) are severe psychiatric disorders that are challenging to treat, often leading to treatment resistance (TR). It is crucial to develop effective methods to identify and treat patients at risk of TR at an early stage in a personalized manner, considering their biological basis, their clinical and psychosocial characteristics. Effective translation of theoretical knowledge into clinical practice is essential for achieving this goal. The Psych-STRATA consortium addresses this research gap through a seven-step approach. First, transdiagnostic biosignatures of SCZ, BD and MDD are identified by GWAS and multi-modal omics signatures associated with treatment outcome and TR (steps 1 and 2). In a next step (step 3), a randomized controlled intervention study is conducted to test the efficacy and safety of an early intensified pharmacological treatment. Following this RCT, a combined clinical and omics-based algorithm will be developed to estimate the risk for TR. This algorithm-based tool will be designed for early detection and management of TR (step 4). This algorithm will then be implemented into a framework of shared treatment decision-making with a novel mental health board (step 5). The final focus of the project is based on patient empowerment, dissemination and education (step 6) as well as the development of a software for fast, effective and individualized treatment decisions (step 7). The project has the potential to change the current trial and error treatment approach towards an evidence-based individualized treatment setting that takes TR risk into account at an early stage.",

keywords = "Depression schizophrenia, Early detection, Early treatment, Precision psychiatry, Treatment resistance",

author = "Baune, \{B T\} and Fromme, \{S E\} and M Aberg and M Adli and A Afantitis and I Akkouh and Andreassen, \{O A\} and C Angulo and S Barlati and C Brasso and P Bucci and M Budde and P Buspavanich and V Cavone and K Demyttenaere and Diaz-Caneja, \{C M\} and M Dierssen and S Djurovic and M Driessen and Ebner-Priemer, \{U W\} and J Engelmann and S Englisch and C Fabbri and P Fossati and H Fr{\"o}hlich and S Gasser and N Gottlieb and E Heirman and A Hofer and O Howes and L Ilzarbe and H Jeung-Maarse and Kessing, \{L V\} and Kockler, \{T D\} and M Land{\'e}n and L Levi and K Lieb and N Lorenzon and J Luykx and M Manchia and \{Martinez de Lagran\}, M and A Minelli and C Moreno and A Mucci and B M{\"u}ller-Myhsok and P Nilsson and C Okhuijsen-Pfeifer and Papavasileiou, \{K D\} and S Papiol and Pardinas, \{A F\} and P Paribello and C Pisanu and M-C Potier and A Reif and R Ricken and S Ripke and P Rocca and D Scherrer and C Schiweck and Schubert, \{K O\} and Schulze, \{T G\} and A Serretti and A Squassina and C Stephan and A Tsoumanis and \{Van der Eycken\}, E and E Vieta and A Vita and Walters, \{J T R\} and D Weichert and M Weiser and Willcocks, \{I R\} and \{Winter-van Rossum\}, I and Young, \{A H\} and Ziller, \{M J\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2025",

month = aug,

doi = "10.1007/s00406-024-01944-3",

language = "English",

volume = "275",

pages = "1453--1464",

journal = "European Archives of Psychiatry and Clinical Neuroscience",

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publisher = "Springer Science and Business Media Deutschland GmbH",

number = "5",

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Baune, BT, Fromme, SE, Aberg, M, Adli, M, Afantitis, A, Akkouh, I, Andreassen, OA, Angulo, C, Barlati, S, Brasso, C, Bucci, P, Budde, M, Buspavanich, P, Cavone, V, Demyttenaere, K, Diaz-Caneja, CM, Dierssen, M, Djurovic, S, Driessen, M, Ebner-Priemer, UW, Engelmann, J, Englisch, S, Fabbri, C, Fossati, P, Fröhlich, H, Gasser, S, Gottlieb, N, Heirman, E, Hofer, A, Howes, O, Ilzarbe, L, Jeung-Maarse, H, Kessing, LV, Kockler, TD, Landén, M, Levi, L, Lieb, K, Lorenzon, N, Luykx, J, Manchia, M, Martinez de Lagran, M, Minelli, A, Moreno, C, Mucci, A, Müller-Myhsok, B, Nilsson, P, Okhuijsen-Pfeifer, C, Papavasileiou, KD, Papiol, S, Pardinas, AF, Paribello, P, Pisanu, C, Potier, M-C, Reif, A, Ricken, R, Ripke, S, Rocca, P, Scherrer, D, Schiweck, C, Schubert, KO, Schulze, TG, Serretti, A, Squassina, A, Stephan, C, Tsoumanis, A, Van der Eycken, E, Vieta, E, Vita, A, Walters, JTR, Weichert, D, Weiser, M, Willcocks, IR, Winter-van Rossum, I, Young, AH & Ziller, MJ 2025, 'A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe', European Archives of Psychiatry and Clinical Neuroscience, vol. 275, no. 5, pp. 1453-1464. https://doi.org/10.1007/s00406-024-01944-3

A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe. / Baune, B T; Fromme, S E; Aberg, M et al.
In: European Archives of Psychiatry and Clinical Neuroscience, Vol. 275, No. 5, 08.2025, p. 1453-1464.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A stratified treatment algorithm in psychiatry

T2 - a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe

AU - Baune, B T

AU - Fromme, S E

AU - Aberg, M

AU - Adli, M

AU - Afantitis, A

AU - Akkouh, I

AU - Andreassen, O A

AU - Angulo, C

AU - Barlati, S

AU - Brasso, C

AU - Bucci, P

AU - Budde, M

AU - Buspavanich, P

AU - Cavone, V

AU - Demyttenaere, K

AU - Diaz-Caneja, C M

AU - Dierssen, M

AU - Djurovic, S

AU - Driessen, M

AU - Ebner-Priemer, U W

AU - Engelmann, J

AU - Englisch, S

AU - Fabbri, C

AU - Fossati, P

AU - Fröhlich, H

AU - Gasser, S

AU - Gottlieb, N

AU - Heirman, E

AU - Hofer, A

AU - Howes, O

AU - Ilzarbe, L

AU - Jeung-Maarse, H

AU - Kessing, L V

AU - Kockler, T D

AU - Landén, M

AU - Levi, L

AU - Lieb, K

AU - Lorenzon, N

AU - Luykx, J

AU - Manchia, M

AU - Martinez de Lagran, M

AU - Minelli, A

AU - Moreno, C

AU - Mucci, A

AU - Müller-Myhsok, B

AU - Nilsson, P

AU - Okhuijsen-Pfeifer, C

AU - Papavasileiou, K D

AU - Papiol, S

AU - Pardinas, A F

AU - Paribello, P

AU - Pisanu, C

AU - Potier, M-C

AU - Reif, A

AU - Ricken, R

AU - Ripke, S

AU - Rocca, P

AU - Scherrer, D

AU - Schiweck, C

AU - Schubert, K O

AU - Schulze, T G

AU - Serretti, A

AU - Squassina, A

AU - Stephan, C

AU - Tsoumanis, A

AU - Van der Eycken, E

AU - Vieta, E

AU - Vita, A

AU - Walters, J T R

AU - Weichert, D

AU - Weiser, M

AU - Willcocks, I R

AU - Winter-van Rossum, I

AU - Young, A H

AU - Ziller, M J

PY - 2025/8

Y1 - 2025/8

N2 - Schizophrenia (SCZ), bipolar (BD) and major depression disorder (MDD) are severe psychiatric disorders that are challenging to treat, often leading to treatment resistance (TR). It is crucial to develop effective methods to identify and treat patients at risk of TR at an early stage in a personalized manner, considering their biological basis, their clinical and psychosocial characteristics. Effective translation of theoretical knowledge into clinical practice is essential for achieving this goal. The Psych-STRATA consortium addresses this research gap through a seven-step approach. First, transdiagnostic biosignatures of SCZ, BD and MDD are identified by GWAS and multi-modal omics signatures associated with treatment outcome and TR (steps 1 and 2). In a next step (step 3), a randomized controlled intervention study is conducted to test the efficacy and safety of an early intensified pharmacological treatment. Following this RCT, a combined clinical and omics-based algorithm will be developed to estimate the risk for TR. This algorithm-based tool will be designed for early detection and management of TR (step 4). This algorithm will then be implemented into a framework of shared treatment decision-making with a novel mental health board (step 5). The final focus of the project is based on patient empowerment, dissemination and education (step 6) as well as the development of a software for fast, effective and individualized treatment decisions (step 7). The project has the potential to change the current trial and error treatment approach towards an evidence-based individualized treatment setting that takes TR risk into account at an early stage.

AB - Schizophrenia (SCZ), bipolar (BD) and major depression disorder (MDD) are severe psychiatric disorders that are challenging to treat, often leading to treatment resistance (TR). It is crucial to develop effective methods to identify and treat patients at risk of TR at an early stage in a personalized manner, considering their biological basis, their clinical and psychosocial characteristics. Effective translation of theoretical knowledge into clinical practice is essential for achieving this goal. The Psych-STRATA consortium addresses this research gap through a seven-step approach. First, transdiagnostic biosignatures of SCZ, BD and MDD are identified by GWAS and multi-modal omics signatures associated with treatment outcome and TR (steps 1 and 2). In a next step (step 3), a randomized controlled intervention study is conducted to test the efficacy and safety of an early intensified pharmacological treatment. Following this RCT, a combined clinical and omics-based algorithm will be developed to estimate the risk for TR. This algorithm-based tool will be designed for early detection and management of TR (step 4). This algorithm will then be implemented into a framework of shared treatment decision-making with a novel mental health board (step 5). The final focus of the project is based on patient empowerment, dissemination and education (step 6) as well as the development of a software for fast, effective and individualized treatment decisions (step 7). The project has the potential to change the current trial and error treatment approach towards an evidence-based individualized treatment setting that takes TR risk into account at an early stage.

KW - Depression schizophrenia

KW - Early detection

KW - Early treatment

KW - Precision psychiatry

KW - Treatment resistance

UR - https://www.scopus.com/pages/publications/85213695030

U2 - 10.1007/s00406-024-01944-3

DO - 10.1007/s00406-024-01944-3

M3 - Article

C2 - 39729102

AN - SCOPUS:85213695030

SN - 0940-1334

VL - 275

SP - 1453

EP - 1464

JO - European Archives of Psychiatry and Clinical Neuroscience

JF - European Archives of Psychiatry and Clinical Neuroscience

IS - 5

ER -

Baune BT, Fromme SE, Aberg M, Adli M, Afantitis A, Akkouh I et al. A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe. European Archives of Psychiatry and Clinical Neuroscience. 2025 Aug;275(5):1453-1464. Epub 2024 Dec 27. doi: 10.1007/s00406-024-01944-3

A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe

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Keywords

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