A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review

Raquel Dávila Fajardo*, Bradley R. Pieters, Jim C.H. Wilde, Hugo A. Heij, Rafal Chrzan, Godelieve Tytgat, Annelies M.C. Mavinkurve-Groothuis, Anne Smets, Petra S. Kroon, An Van Damme, Kees P. van de Ven, Ronald R. de Krijger, Marc R. Lilien, Marc H. Wijnen, Marry M. van den Heuvel-Eibrink, Geert O. Janssens

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Purpose: To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature. Results (Methods and Case Description): Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and one metachronous) underwent enucleation and perioperative brachytherapy to the tumor bed. With a minimum follow-up of 5 years, all three patients are in continuous complete remission with preserved kidney function. Conclusions: Although nephron sparing surgery aiming at tumor free-margins remains the gold standard for bilateral WT, tumor enucleation followed by brachytherapy may be considered in carefully selected patients at high risk for end-stage kidney failure. Given the rarity and complexity of the procedure, concentration of care of such patients is mandatory.

Original languageEnglish
Pages (from-to)478-484
Number of pages7
JournalBrachytherapy
Volume20
Issue number2
DOIs
Publication statusPublished - 1 Mar 2021

Keywords

  • Brachytherapy
  • Enucleation
  • Wilms tumor

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