A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review

Raquel Dávila Fajardo; Bradley R. Pieters; Jim C.H. Wilde; Hugo A. Heij; Rafal Chrzan; Godelieve Tytgat; Annelies M.C. Mavinkurve-Groothuis; Anne Smets; Petra S. Kroon; An Van Damme; Kees P. van de Ven; Ronald R. de Krijger; Marc R. Lilien; Marc H. Wijnen; Marry M. van den Heuvel-Eibrink; Geert O. Janssens

doi:10.1016/j.brachy.2020.09.001

A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review

Raquel Dávila Fajardo^*, Bradley R. Pieters, Jim C.H. Wilde, Hugo A. Heij, Rafal Chrzan, Godelieve Tytgat, Annelies M.C. Mavinkurve-Groothuis, Anne Smets, Petra S. Kroon, An Van Damme, Kees P. van de Ven, Ronald R. de Krijger, Marc R. Lilien, Marc H. Wijnen, Marry M. van den Heuvel-Eibrink, Geert O. Janssens

^*Corresponding author for this work

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Abstract

Purpose: To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature. Results (Methods and Case Description): Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and one metachronous) underwent enucleation and perioperative brachytherapy to the tumor bed. With a minimum follow-up of 5 years, all three patients are in continuous complete remission with preserved kidney function. Conclusions: Although nephron sparing surgery aiming at tumor free-margins remains the gold standard for bilateral WT, tumor enucleation followed by brachytherapy may be considered in carefully selected patients at high risk for end-stage kidney failure. Given the rarity and complexity of the procedure, concentration of care of such patients is mandatory.

Original language	English
Pages (from-to)	478-484
Number of pages	7
Journal	Brachytherapy
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.brachy.2020.09.001
Publication status	Published - 1 Mar 2021

Keywords

Brachytherapy
Enucleation
Wilms tumor

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10.1016/j.brachy.2020.09.001

1-s2.0-S1538472120301999-mainFinal published version, 762 KBLicence: CC BY

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Dávila Fajardo, R., Pieters, B. R., Wilde, J. C. H., Heij, H. A., Chrzan, R., Tytgat, G., Mavinkurve-Groothuis, A. M. C., Smets, A., Kroon, P. S., Van Damme, A., van de Ven, K. P., de Krijger, R. R., Lilien, M. R., Wijnen, M. H., van den Heuvel-Eibrink, M. M., & Janssens, G. O. (2021). A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review. Brachytherapy, 20(2), 478-484. https://doi.org/10.1016/j.brachy.2020.09.001

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title = "A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review",

abstract = "Purpose: To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature. Results (Methods and Case Description): Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and one metachronous) underwent enucleation and perioperative brachytherapy to the tumor bed. With a minimum follow-up of 5 years, all three patients are in continuous complete remission with preserved kidney function. Conclusions: Although nephron sparing surgery aiming at tumor free-margins remains the gold standard for bilateral WT, tumor enucleation followed by brachytherapy may be considered in carefully selected patients at high risk for end-stage kidney failure. Given the rarity and complexity of the procedure, concentration of care of such patients is mandatory.",

keywords = "Brachytherapy, Enucleation, Wilms tumor",

author = "{D{\'a}vila Fajardo}, Raquel and Pieters, {Bradley R.} and Wilde, {Jim C.H.} and Heij, {Hugo A.} and Rafal Chrzan and Godelieve Tytgat and Mavinkurve-Groothuis, {Annelies M.C.} and Anne Smets and Kroon, {Petra S.} and {Van Damme}, An and {van de Ven}, {Kees P.} and {de Krijger}, {Ronald R.} and Lilien, {Marc R.} and Wijnen, {Marc H.} and {van den Heuvel-Eibrink}, {Marry M.} and Janssens, {Geert O.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2021",

month = mar,

day = "1",

doi = "10.1016/j.brachy.2020.09.001",

language = "English",

volume = "20",

pages = "478--484",

journal = "Brachytherapy",

issn = "1538-4721",

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Dávila Fajardo, R, Pieters, BR, Wilde, JCH, Heij, HA, Chrzan, R, Tytgat, G, Mavinkurve-Groothuis, AMC, Smets, A, Kroon, PS, Van Damme, A, van de Ven, KP, de Krijger, RR, Lilien, MR, Wijnen, MH , van den Heuvel-Eibrink, MM & Janssens, GO 2021, 'A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review', Brachytherapy, vol. 20, no. 2, pp. 478-484. https://doi.org/10.1016/j.brachy.2020.09.001

TY - JOUR

T1 - A Role of brachytherapy in bilateral Wilms tumors

T2 - A long-term follow-up of three highly selected cases and literature review

AU - Dávila Fajardo, Raquel

AU - Pieters, Bradley R.

AU - Wilde, Jim C.H.

AU - Heij, Hugo A.

AU - Chrzan, Rafal

AU - Tytgat, Godelieve

AU - Mavinkurve-Groothuis, Annelies M.C.

AU - Smets, Anne

AU - Kroon, Petra S.

AU - Van Damme, An

AU - van de Ven, Kees P.

AU - de Krijger, Ronald R.

AU - Lilien, Marc R.

AU - Wijnen, Marc H.

AU - van den Heuvel-Eibrink, Marry M.

AU - Janssens, Geert O.

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Purpose: To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature. Results (Methods and Case Description): Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and one metachronous) underwent enucleation and perioperative brachytherapy to the tumor bed. With a minimum follow-up of 5 years, all three patients are in continuous complete remission with preserved kidney function. Conclusions: Although nephron sparing surgery aiming at tumor free-margins remains the gold standard for bilateral WT, tumor enucleation followed by brachytherapy may be considered in carefully selected patients at high risk for end-stage kidney failure. Given the rarity and complexity of the procedure, concentration of care of such patients is mandatory.

AB - Purpose: To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature. Results (Methods and Case Description): Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and one metachronous) underwent enucleation and perioperative brachytherapy to the tumor bed. With a minimum follow-up of 5 years, all three patients are in continuous complete remission with preserved kidney function. Conclusions: Although nephron sparing surgery aiming at tumor free-margins remains the gold standard for bilateral WT, tumor enucleation followed by brachytherapy may be considered in carefully selected patients at high risk for end-stage kidney failure. Given the rarity and complexity of the procedure, concentration of care of such patients is mandatory.

KW - Brachytherapy

KW - Enucleation

KW - Wilms tumor

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U2 - 10.1016/j.brachy.2020.09.001

DO - 10.1016/j.brachy.2020.09.001

M3 - Review article

AN - SCOPUS:85097479143

SN - 1538-4721

VL - 20

SP - 478

EP - 484

JO - Brachytherapy

JF - Brachytherapy

IS - 2

ER -

A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review

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