A Role for New Brain Magnetic Resonance Imaging Modalities in Daily Clinical Practice: Protocol of the Prediction of Cognitive Recovery After Stroke (PROCRAS) Study

Hugo P Aben; Yael D Reijmer; Johanna Ma Visser-Meily; Jacoba M Spikman; Jeroen de Bresser; Geert Jan Biessels; Paul Lm de Kort

doi:10.2196/resprot.9431

A Role for New Brain Magnetic Resonance Imaging Modalities in Daily Clinical Practice: Protocol of the Prediction of Cognitive Recovery After Stroke (PROCRAS) Study

Hugo P Aben
, Yael D Reijmer
, Johanna Ma Visser-Meily
, Jacoba M Spikman
, Jeroen de Bresser
, Geert Jan Biessels
, Paul Lm de Kort

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Cognitive impairment is common after acute ischemic stroke, affecting up to 75% of the patients. About half of the patients will show recovery, whereas the others will remain cognitively impaired or deteriorate. It is difficult to predict these different cognitive outcomes. Objective: The objective of this study is to investigate whether diffusion tensor imaging-based measures of brain connectivity predict cognitive recovery after 1 year, in addition to patient characteristics and stroke severity. A specific premise of the Prediction of Cognitive Recovery After Stroke (PROCRAS) study is that it is conducted in a daily practice setting. Methods: The PROCRAS study is a prospective, mono-center cohort study conducted in a large teaching hospital in the Netherlands. A total of 350 patients suffering from an ischemic stroke who screen positive for cognitive impairment on the Montreal Cognitive Assessment (MoCA<26) in the acute stage will undergo a 3Tesla-Magnetic Resonance Imaging (3T-MRI) with a diffusion-weighted sequence and a neuropsychological assessment. Patients will be classified as being unimpaired, as having a mild vascular cognitive disorder, or as having a major vascular cognitive disorder. One year after stroke, patients will undergo follow-up neuropsychological assessment. The primary endpoint is recovery of cognitive function 1 year after stroke in patients with a confirmed poststroke cognitive disorder. The secondary endpoint is deterioration of cognitive function in the first year after stroke. Results: The study is already ongoing for 1.5 years, and thus far, 252 patients have provided written informed consent. Final results are expected in June 2019. Conclusions: The PROCRAS study will show the additional predictive value of diffusion tensor imaging-based measures of brain connectivity for cognitive outcome at 1 year in patients with a poststroke cognitive disorder in a daily clinical practice setting.

Original language	English
Article number	e127
Pages (from-to)	e127
Journal	JMIR Research Protocols
Volume	7
Issue number	5
DOIs	https://doi.org/10.2196/resprot.9431
Publication status	Published - May 2018

Keywords

Anisotropy
Brain infarction
Cognitive dysfunction
Diffusion magnetic resonance imaging
Diffusion tensor imaging
Stroke

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Aben, H. P., Reijmer, Y. D., Visser-Meily, J. M., Spikman, J. M., de Bresser, J., Biessels, G. J., & de Kort, P. L. (2018). A Role for New Brain Magnetic Resonance Imaging Modalities in Daily Clinical Practice: Protocol of the Prediction of Cognitive Recovery After Stroke (PROCRAS) Study. JMIR Research Protocols, 7(5), e127. Article e127. https://doi.org/10.2196/resprot.9431

@article{435d9672e0f2424f878e0ea53512d31d,

title = "A Role for New Brain Magnetic Resonance Imaging Modalities in Daily Clinical Practice: Protocol of the Prediction of Cognitive Recovery After Stroke (PROCRAS) Study",

abstract = "Background: Cognitive impairment is common after acute ischemic stroke, affecting up to 75\% of the patients. About half of the patients will show recovery, whereas the others will remain cognitively impaired or deteriorate. It is difficult to predict these different cognitive outcomes. Objective: The objective of this study is to investigate whether diffusion tensor imaging-based measures of brain connectivity predict cognitive recovery after 1 year, in addition to patient characteristics and stroke severity. A specific premise of the Prediction of Cognitive Recovery After Stroke (PROCRAS) study is that it is conducted in a daily practice setting. Methods: The PROCRAS study is a prospective, mono-center cohort study conducted in a large teaching hospital in the Netherlands. A total of 350 patients suffering from an ischemic stroke who screen positive for cognitive impairment on the Montreal Cognitive Assessment (MoCA<26) in the acute stage will undergo a 3Tesla-Magnetic Resonance Imaging (3T-MRI) with a diffusion-weighted sequence and a neuropsychological assessment. Patients will be classified as being unimpaired, as having a mild vascular cognitive disorder, or as having a major vascular cognitive disorder. One year after stroke, patients will undergo follow-up neuropsychological assessment. The primary endpoint is recovery of cognitive function 1 year after stroke in patients with a confirmed poststroke cognitive disorder. The secondary endpoint is deterioration of cognitive function in the first year after stroke. Results: The study is already ongoing for 1.5 years, and thus far, 252 patients have provided written informed consent. Final results are expected in June 2019. Conclusions: The PROCRAS study will show the additional predictive value of diffusion tensor imaging-based measures of brain connectivity for cognitive outcome at 1 year in patients with a poststroke cognitive disorder in a daily clinical practice setting.",

keywords = "Anisotropy, Brain infarction, Cognitive dysfunction, Diffusion magnetic resonance imaging, Diffusion tensor imaging, Stroke",

author = "Aben, \{Hugo P\} and Reijmer, \{Yael D\} and Visser-Meily, \{Johanna Ma\} and Spikman, \{Jacoba M\} and \{de Bresser\}, Jeroen and Biessels, \{Geert Jan\} and \{de Kort\}, \{Paul Lm\}",

note = "Publisher Copyright: {\textcopyright} Hugo P Aben, Yael D Reijmer, Johanna MA Visser-Meily, Jacoba M Spikman, Jeroen de Bresser, Geert Jan Biessels, Paul LM de Kort.",

year = "2018",

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A Role for New Brain Magnetic Resonance Imaging Modalities in Daily Clinical Practice: Protocol of the Prediction of Cognitive Recovery After Stroke (PROCRAS) Study. / Aben, Hugo P; Reijmer, Yael D; Visser-Meily, Johanna Ma et al.
In: JMIR Research Protocols, Vol. 7, No. 5, e127, 05.2018, p. e127.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A Role for New Brain Magnetic Resonance Imaging Modalities in Daily Clinical Practice

T2 - Protocol of the Prediction of Cognitive Recovery After Stroke (PROCRAS) Study

AU - Aben, Hugo P

AU - Reijmer, Yael D

AU - Visser-Meily, Johanna Ma

AU - Spikman, Jacoba M

AU - de Bresser, Jeroen

AU - Biessels, Geert Jan

AU - de Kort, Paul Lm

N1 - Publisher Copyright: © Hugo P Aben, Yael D Reijmer, Johanna MA Visser-Meily, Jacoba M Spikman, Jeroen de Bresser, Geert Jan Biessels, Paul LM de Kort.

PY - 2018/5

Y1 - 2018/5

N2 - Background: Cognitive impairment is common after acute ischemic stroke, affecting up to 75% of the patients. About half of the patients will show recovery, whereas the others will remain cognitively impaired or deteriorate. It is difficult to predict these different cognitive outcomes. Objective: The objective of this study is to investigate whether diffusion tensor imaging-based measures of brain connectivity predict cognitive recovery after 1 year, in addition to patient characteristics and stroke severity. A specific premise of the Prediction of Cognitive Recovery After Stroke (PROCRAS) study is that it is conducted in a daily practice setting. Methods: The PROCRAS study is a prospective, mono-center cohort study conducted in a large teaching hospital in the Netherlands. A total of 350 patients suffering from an ischemic stroke who screen positive for cognitive impairment on the Montreal Cognitive Assessment (MoCA<26) in the acute stage will undergo a 3Tesla-Magnetic Resonance Imaging (3T-MRI) with a diffusion-weighted sequence and a neuropsychological assessment. Patients will be classified as being unimpaired, as having a mild vascular cognitive disorder, or as having a major vascular cognitive disorder. One year after stroke, patients will undergo follow-up neuropsychological assessment. The primary endpoint is recovery of cognitive function 1 year after stroke in patients with a confirmed poststroke cognitive disorder. The secondary endpoint is deterioration of cognitive function in the first year after stroke. Results: The study is already ongoing for 1.5 years, and thus far, 252 patients have provided written informed consent. Final results are expected in June 2019. Conclusions: The PROCRAS study will show the additional predictive value of diffusion tensor imaging-based measures of brain connectivity for cognitive outcome at 1 year in patients with a poststroke cognitive disorder in a daily clinical practice setting.

AB - Background: Cognitive impairment is common after acute ischemic stroke, affecting up to 75% of the patients. About half of the patients will show recovery, whereas the others will remain cognitively impaired or deteriorate. It is difficult to predict these different cognitive outcomes. Objective: The objective of this study is to investigate whether diffusion tensor imaging-based measures of brain connectivity predict cognitive recovery after 1 year, in addition to patient characteristics and stroke severity. A specific premise of the Prediction of Cognitive Recovery After Stroke (PROCRAS) study is that it is conducted in a daily practice setting. Methods: The PROCRAS study is a prospective, mono-center cohort study conducted in a large teaching hospital in the Netherlands. A total of 350 patients suffering from an ischemic stroke who screen positive for cognitive impairment on the Montreal Cognitive Assessment (MoCA<26) in the acute stage will undergo a 3Tesla-Magnetic Resonance Imaging (3T-MRI) with a diffusion-weighted sequence and a neuropsychological assessment. Patients will be classified as being unimpaired, as having a mild vascular cognitive disorder, or as having a major vascular cognitive disorder. One year after stroke, patients will undergo follow-up neuropsychological assessment. The primary endpoint is recovery of cognitive function 1 year after stroke in patients with a confirmed poststroke cognitive disorder. The secondary endpoint is deterioration of cognitive function in the first year after stroke. Results: The study is already ongoing for 1.5 years, and thus far, 252 patients have provided written informed consent. Final results are expected in June 2019. Conclusions: The PROCRAS study will show the additional predictive value of diffusion tensor imaging-based measures of brain connectivity for cognitive outcome at 1 year in patients with a poststroke cognitive disorder in a daily clinical practice setting.

KW - Anisotropy

KW - Brain infarction

KW - Cognitive dysfunction

KW - Diffusion magnetic resonance imaging

KW - Diffusion tensor imaging

KW - Stroke

UR - https://www.scopus.com/pages/publications/85063259013

U2 - 10.2196/resprot.9431

DO - 10.2196/resprot.9431

M3 - Article

C2 - 29807883

SN - 1929-0748

VL - 7

SP - e127

JO - JMIR Research Protocols

JF - JMIR Research Protocols

IS - 5

M1 - e127

ER -

A Role for New Brain Magnetic Resonance Imaging Modalities in Daily Clinical Practice: Protocol of the Prediction of Cognitive Recovery After Stroke (PROCRAS) Study

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