A review of methods for addressing components of interventions in meta-analysis

Maria Petropoulou; Orestis Efthimiou; Gerta Rücker; Guido Schwarzer; Toshi A. Furukawa; Alessandro Pompoli; Huiberdina L. Koek; Cinzia Del Giovane; Nicolas Rodondi; Dimitris Mavridis

doi:10.1371/journal.pone.0246631

A review of methods for addressing components of interventions in meta-analysis

Maria Petropoulou^*, Orestis Efthimiou, Gerta Rücker, Guido Schwarzer, Toshi A. Furukawa, Alessandro Pompoli, Huiberdina L. Koek, Cinzia Del Giovane, Nicolas Rodondi, Dimitris Mavridis

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Many healthcare interventions are complex, consisting of multiple, possibly interacting, components. Several methodological articles addressing complex interventions in the metaanalytical context have been published. We hereby provide an overview of methods used to evaluate the effects of complex interventions with meta-analytical models. We summarized the methodology, highlighted new developments, and described the benefits, drawbacks, and potential challenges of each identified method. We expect meta-analytical methods focusing on components of several multicomponent interventions to become increasingly popular due to recently developed, easy-to-use, software tools that can be used to conduct the relevant analyses. The different meta-analytical methods are illustrated through two examples comparing psychotherapies for panic disorder.

Original language	English
Article number	e0246631
Pages (from-to)	1-15
Journal	PLoS ONE
Volume	16
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0246631
Publication status	Published - 8 Feb 2021

Keywords

Animals
Data Analysis
Delivery of Health Care/methods
Humans
Meta-Analysis as Topic
Research Design
Software

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journal.pone.0246631Final published version, 1.77 MBLicence: CC BY

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AU - Pompoli, Alessandro

AU - Koek, Huiberdina L.

AU - Del Giovane, Cinzia

AU - Rodondi, Nicolas

AU - Mavridis, Dimitris

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A review of methods for addressing components of interventions in meta-analysis

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