A RAG driver on the road to pediatric ALL

Roland P Kuiper; Esmé Waanders

doi:10.1038/ng.2879

A RAG driver on the road to pediatric ALL

Roland P Kuiper^*, Esmé Waanders

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic

Abstract

Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1-positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism.

Original language	English
Pages (from-to)	96-8
Number of pages	3
Journal	Nature Genetics
Volume	46
Issue number	2
DOIs	https://doi.org/10.1038/ng.2879
Publication status	Published - Feb 2014
Externally published	Yes

Keywords

Core Binding Factor Alpha 2 Subunit/genetics
Gene Expression Regulation, Neoplastic/genetics
Gene Rearrangement/genetics
Genetic Variation
Homeodomain Proteins/genetics
Humans
Oncogene Proteins, Fusion/genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics
Recombination, Genetic/genetics

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10.1038/ng.2879

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title = "A RAG driver on the road to pediatric ALL",

abstract = "Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1-positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism. ",

keywords = "Core Binding Factor Alpha 2 Subunit/genetics, Gene Expression Regulation, Neoplastic/genetics, Gene Rearrangement/genetics, Genetic Variation, Homeodomain Proteins/genetics, Humans, Oncogene Proteins, Fusion/genetics, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics, Recombination, Genetic/genetics",

author = "Kuiper, \{Roland P\} and Esm{\'e} Waanders",

year = "2014",

month = feb,

doi = "10.1038/ng.2879",

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journal = "Nature Genetics",

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AU - Waanders, Esmé

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AB - Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1-positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism.

KW - Core Binding Factor Alpha 2 Subunit/genetics

KW - Gene Expression Regulation, Neoplastic/genetics

KW - Gene Rearrangement/genetics

KW - Genetic Variation

KW - Homeodomain Proteins/genetics

KW - Humans

KW - Oncogene Proteins, Fusion/genetics

KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics

KW - Recombination, Genetic/genetics

U2 - 10.1038/ng.2879

DO - 10.1038/ng.2879

M3 - Article

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SN - 1061-4036

VL - 46

SP - 96

EP - 98

JO - Nature Genetics

JF - Nature Genetics

IS - 2

ER -

A RAG driver on the road to pediatric ALL

Abstract

Keywords

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