@article{9f562e0999134cc2bf0fbd7ff451a399,
title = "A prospective population-based study of gestational vitamin D status and brain morphology in preadolescents",
abstract = "Low vitamin D level during pregnancy has been associated with adverse neurodevelopmental outcomes such as autism spectrum disorders (ASD) in children. However, the underlying neurobiological mechanism remains largely unknown. This study investigated the association between gestational 25-hydroxyvitamin D [25(OH)D] concentration and brain morphology in 2597 children at the age of 10 years in the population-based Generation R Study. We studied both 25(OH)D in maternal venous blood in mid-gestation and in umbilical cord blood at delivery, in relation to brain volumetric measures and surface-based cortical metrics including cortical thickness, surface area, and gyrification using linear regression. We found exposure to higher maternal 25(OH)D concentrations in mid-gestation was associated with a larger cerebellar volume in children (b = 0.02, 95%CI 0.001 to 0.04), however this association did not remain after correction for multiple comparisons. In addition, children exposed to persistently deficient (i.e., <25 nmol/L) 25(OH)D concentration from mid-gestation to delivery showed less cerebral gray matter and white matter volumes, as well as smaller surface area and less gyrification at 10 years than those with persistently sufficient (i.e., ≥50 nmol/L) 25(OH)D concentration. These results suggest temporal relationships between gestational vitamin D concentration and brain morphological development in children.",
keywords = "Epidemiology, Neuroimaging, Pregnancy, Vitamin D",
author = "Runyu Zou and {El Marroun}, Hanan and McGrath, {John J.} and Muetzel, {Ryan L.} and Manon Hillegers and Tonya White and Henning Tiemeier",
note = "Funding Information: This work was supported by China Scholarship Council (201606100056 to R. Zou); the Erasmus University Rotterdam Fellowship 2014 (H. El Marroun); Stichting Volksbond Rotterdam, Netherlands (H. El Marroun); the Dutch Brain Foundation, Netherlands (GH2016.2.01 to H. El Marroun); a Niels Bohr Professorship from the Danish National Research Foundation (J. J. McGrath); the Netherlands Organization for Health Research and Development, Netherlands (TOP 91211021 to T. White), and (016. VICI.170.200 to H. Tiemeier); the European Union's Horizon 2020 research and innovation program (DynaHEALTH 633595) and (LifeCycle 733206). The vitamin D assay was supported by the National Health and Medical Research Council APP1062846, APP1056929. Shipping of the samples was supported by FP7 Nutrimenthe 212652. Supercomputing resources were supported by the Netherlands Organization for Scientific Research (Exacte Wetenschappen) and SURFsara (Cartesius Computer Cluster, www.surfsara.nl). The general design of the Generation R Study was made possible by financial support from the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, ZonMw, the Netherlands Organization for Scientific Research, and the Ministry of Health, Welfare, and Sport. Funding Information: This work was supported by China Scholarship Council ( 201606100056 to R. Zou); the Erasmus University Rotterdam Fellowship 2014 (H. El Marroun); Stichting Volksbond Rotterdam, Netherlands (H. El Marroun); the Dutch Brain Foundation, Netherlands (GH2016.2.01 to H. El Marroun); a Niels Bohr Professorship from the Danish National Research Foundation (J. J. McGrath); the Netherlands Organization for Health Research and Development, Netherlands (TOP 91211021 to T. White), and (016. VICI.170.200 to H. Tiemeier); the European Union{\textquoteright}s Horizon 2020 research and innovation program ( DynaHEALTH 633595 ) and ( LifeCycle 73320 6). The vitamin D assay was supported by the National Health and Medical Research Council APP1062846 , APP1056929 . Shipping of the samples was supported by FP7 Nutrimenthe 212652. Supercomputing resources were supported by the Netherlands Organization for Scientific Research (Exacte Wetenschappen) and SURFsara (Cartesius Computer Cluster, www.surfsara.nl ). The general design of the Generation R Study was made possible by financial support from the Erasmus Medical Center, Rotterdam , the Erasmus University Rotterdam , ZonMw, the Netherlands Organization for Scientific Research , and the Ministry of Health, Welfare, and Sport . Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = apr,
day = "1",
doi = "10.1016/j.neuroimage.2020.116514",
language = "English",
volume = "209",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
}