A primer on the immune system in the pathogenesis and treatment of atherosclerosis

Dolf Segers; Hector M. Garcia-Garcia; Caroline Cheng; Rini De Crom; Rob Krams; Jolanda J. Wentzel; Anton F.W. Van der Steen; Patrick W. Serruys; Pieter J.M. Leenen; Jon D. Laman

doi:10.4244/EIJV4I3A67

A primer on the immune system in the pathogenesis and treatment of atherosclerosis

Dolf Segers, Hector M. Garcia-Garcia, Caroline Cheng, Rini De Crom, Rob Krams, Jolanda J. Wentzel, Anton F.W. Van der Steen, Patrick W. Serruys, Pieter J.M. Leenen, Jon D. Laman^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Atherosclerosis is currently appreciated as a disease with a large inflammatory component. The underlying mechanisms, which are uncovered in a rapid pace, are greatly interconnected and as such very complex. Nevertheless, for clinicians it is important have some degree of insight in these immunologic mechanisms in order to interpret the current research advances. The aim of this review is to supply clinicians with this knowledge, avoiding too much detail. All the relevant immunologic basics will be discussed at first, followed by the immunity related theories of atherosclerosis. Finally, current and new immune-modulatory therapies will be discussed.

Original language	English
Pages (from-to)	378-390
Number of pages	13
Journal	EuroIntervention
Volume	4
Issue number	3
DOIs	https://doi.org/10.4244/EIJV4I3A67
Publication status	Published - 2008
Externally published	Yes

Keywords

Atherosclerosis
Immunity
Immunomodulation
OxLDL

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title = "A primer on the immune system in the pathogenesis and treatment of atherosclerosis",

abstract = "Atherosclerosis is currently appreciated as a disease with a large inflammatory component. The underlying mechanisms, which are uncovered in a rapid pace, are greatly interconnected and as such very complex. Nevertheless, for clinicians it is important have some degree of insight in these immunologic mechanisms in order to interpret the current research advances. The aim of this review is to supply clinicians with this knowledge, avoiding too much detail. All the relevant immunologic basics will be discussed at first, followed by the immunity related theories of atherosclerosis. Finally, current and new immune-modulatory therapies will be discussed.",

keywords = "Atherosclerosis, Immunity, Immunomodulation, OxLDL",

author = "Dolf Segers and Garcia-Garcia, {Hector M.} and Caroline Cheng and {De Crom}, Rini and Rob Krams and Wentzel, {Jolanda J.} and {Van der Steen}, {Anton F.W.} and Serruys, {Patrick W.} and Leenen, {Pieter J.M.} and Laman, {Jon D.}",

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T1 - A primer on the immune system in the pathogenesis and treatment of atherosclerosis

AU - Segers, Dolf

AU - Garcia-Garcia, Hector M.

AU - Cheng, Caroline

AU - De Crom, Rini

AU - Krams, Rob

AU - Wentzel, Jolanda J.

AU - Van der Steen, Anton F.W.

AU - Serruys, Patrick W.

AU - Leenen, Pieter J.M.

AU - Laman, Jon D.

PY - 2008

Y1 - 2008

N2 - Atherosclerosis is currently appreciated as a disease with a large inflammatory component. The underlying mechanisms, which are uncovered in a rapid pace, are greatly interconnected and as such very complex. Nevertheless, for clinicians it is important have some degree of insight in these immunologic mechanisms in order to interpret the current research advances. The aim of this review is to supply clinicians with this knowledge, avoiding too much detail. All the relevant immunologic basics will be discussed at first, followed by the immunity related theories of atherosclerosis. Finally, current and new immune-modulatory therapies will be discussed.

AB - Atherosclerosis is currently appreciated as a disease with a large inflammatory component. The underlying mechanisms, which are uncovered in a rapid pace, are greatly interconnected and as such very complex. Nevertheless, for clinicians it is important have some degree of insight in these immunologic mechanisms in order to interpret the current research advances. The aim of this review is to supply clinicians with this knowledge, avoiding too much detail. All the relevant immunologic basics will be discussed at first, followed by the immunity related theories of atherosclerosis. Finally, current and new immune-modulatory therapies will be discussed.

KW - Atherosclerosis

KW - Immunity

KW - Immunomodulation

KW - OxLDL

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DO - 10.4244/EIJV4I3A67

M3 - Review article

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AN - SCOPUS:59049085841

SN - 1774-024X

VL - 4

SP - 378

EP - 390

JO - EuroIntervention

JF - EuroIntervention

IS - 3

ER -

A primer on the immune system in the pathogenesis and treatment of atherosclerosis

Abstract

Keywords

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