TY - JOUR
T1 - A novel safety assessment strategy for non-intentionally added substances (NIAS) in carton food contact materials
AU - Koster, Sander
AU - Rennen, Monique
AU - Leeman, Winfried
AU - Houben, Geert
AU - Muilwijk, Bas
AU - van Acker, Frederique
AU - Krul, Lisette
PY - 2014/1/1
Y1 - 2014/1/1
N2 - One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess their health risk upon exposure, whereas the health relevance at low exposure levels might not even be an issue. This paper describes a scientifically based, but pragmatic safety assessment approach for unknown substances present at low exposure levels in food contact matrices. This complex mixture safety assessment strategy (CoMSAS) enables one to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure, and allows one to focus on the substances of potential health concern. In particular, substances for which exposure will be below certain thresholds may be considered not of health relevance in case specific classes of substances are excluded. This can reduce the amount of work needed for identification, characterisation and evaluation of unknown substances at low concentration. The CoMSAS approach is presented in this paper using a safety assessment of unknown NIAS that may migrate from three carton samples.
AB - One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess their health risk upon exposure, whereas the health relevance at low exposure levels might not even be an issue. This paper describes a scientifically based, but pragmatic safety assessment approach for unknown substances present at low exposure levels in food contact matrices. This complex mixture safety assessment strategy (CoMSAS) enables one to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure, and allows one to focus on the substances of potential health concern. In particular, substances for which exposure will be below certain thresholds may be considered not of health relevance in case specific classes of substances are excluded. This can reduce the amount of work needed for identification, characterisation and evaluation of unknown substances at low concentration. The CoMSAS approach is presented in this paper using a safety assessment of unknown NIAS that may migrate from three carton samples.
KW - assessment
KW - complex mixture safety assessment strategy
KW - CoMSAS
KW - evaluation
KW - food contact materials
KW - food matrix
KW - NIAS
KW - non-intentionally added substances
KW - safety
KW - threshold of toxicological concern
KW - TTC
UR - http://www.scopus.com/inward/record.url?scp=84897370727&partnerID=8YFLogxK
U2 - 10.1080/19440049.2013.866718
DO - 10.1080/19440049.2013.866718
M3 - Article
C2 - 24237267
AN - SCOPUS:84897370727
SN - 1944-0049
VL - 31
SP - 422
EP - 443
JO - Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
JF - Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
IS - 3
ER -