A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering: a randomized prospective proof of concept study

Evangelos G Papanikolaou; Willem Verpoest; Human Fatemi; Basil Tarlatzis; Paul Devroey; Herman Tournaye

doi:10.1016/j.fertnstert.2010.09.023

A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering: a randomized prospective proof of concept study

Evangelos G Papanikolaou^*, Willem Verpoest, Human Fatemi, Basil Tarlatzis, Paul Devroey, Herman Tournaye

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This pilot study investigates the role of luteal supplementation with recombinant LH in an attempt to reverse the poor reproductive outcome previously noticed after GnRH-agonist triggering of final oocyte maturation for IVF. Similar implantation rates were achieved with the novel recombinant LH luteal supplementation scheme compared with the standard luteal P protocol (25.0% vs. 26.7%, respectively). No cases of ovarian hyperstimulation syndrome (OHSS) were noticed in either group.

Original language	English
Pages (from-to)	1174-1177
Number of pages	4
Journal	Fertility and Sterility
Volume	95
Issue number	3
DOIs	https://doi.org/10.1016/j.fertnstert.2010.09.023
Publication status	Published - 1 Mar 2011
Externally published	Yes

Keywords

Adult
Chorionic Gonadotropin
Drug Therapy, Combination
Female
Fertilization in Vitro
Gonadotropin-Releasing Hormone/agonists
Humans
Luteinizing Hormone/administration & dosage
Ovulation/drug effects
Ovulation Induction/methods
Pilot Projects
Pregnancy
Pregnancy Rate
Recombinant Proteins/administration & dosage

Access to Document

10.1016/j.fertnstert.2010.09.023

Fingerprint

Dive into the research topics of 'A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering: a randomized prospective proof of concept study'. Together they form a unique fingerprint.

Cite this

Papanikolaou, E. G., Verpoest, W., Fatemi, H., Tarlatzis, B., Devroey, P., & Tournaye, H. (2011). A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering: a randomized prospective proof of concept study. Fertility and Sterility, 95(3), 1174-1177. https://doi.org/10.1016/j.fertnstert.2010.09.023

Papanikolaou, Evangelos G ; Verpoest, Willem ; Fatemi, Human et al. / A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering : a randomized prospective proof of concept study. In: Fertility and Sterility. 2011 ; Vol. 95, No. 3. pp. 1174-1177.

@article{d28fc63f812346aa8fcc19329b653a27,

title = "A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering: a randomized prospective proof of concept study",

abstract = "This pilot study investigates the role of luteal supplementation with recombinant LH in an attempt to reverse the poor reproductive outcome previously noticed after GnRH-agonist triggering of final oocyte maturation for IVF. Similar implantation rates were achieved with the novel recombinant LH luteal supplementation scheme compared with the standard luteal P protocol (25.0% vs. 26.7%, respectively). No cases of ovarian hyperstimulation syndrome (OHSS) were noticed in either group.",

keywords = "Adult, Chorionic Gonadotropin, Drug Therapy, Combination, Female, Fertilization in Vitro, Gonadotropin-Releasing Hormone/agonists, Humans, Luteinizing Hormone/administration & dosage, Ovulation/drug effects, Ovulation Induction/methods, Pilot Projects, Pregnancy, Pregnancy Rate, Recombinant Proteins/administration & dosage",

author = "Papanikolaou, {Evangelos G} and Willem Verpoest and Human Fatemi and Basil Tarlatzis and Paul Devroey and Herman Tournaye",

year = "2011",

month = mar,

day = "1",

doi = "10.1016/j.fertnstert.2010.09.023",

language = "English",

volume = "95",

pages = "1174--1177",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier",

number = "3",

}

Papanikolaou, EG, Verpoest, W, Fatemi, H, Tarlatzis, B, Devroey, P & Tournaye, H 2011, 'A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering: a randomized prospective proof of concept study', Fertility and Sterility, vol. 95, no. 3, pp. 1174-1177. https://doi.org/10.1016/j.fertnstert.2010.09.023

A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering: a randomized prospective proof of concept study. / Papanikolaou, Evangelos G; Verpoest, Willem; Fatemi, Human et al.
In: Fertility and Sterility, Vol. 95, No. 3, 01.03.2011, p. 1174-1177.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering

T2 - a randomized prospective proof of concept study

AU - Papanikolaou, Evangelos G

AU - Verpoest, Willem

AU - Fatemi, Human

AU - Tarlatzis, Basil

AU - Devroey, Paul

AU - Tournaye, Herman

PY - 2011/3/1

Y1 - 2011/3/1

N2 - This pilot study investigates the role of luteal supplementation with recombinant LH in an attempt to reverse the poor reproductive outcome previously noticed after GnRH-agonist triggering of final oocyte maturation for IVF. Similar implantation rates were achieved with the novel recombinant LH luteal supplementation scheme compared with the standard luteal P protocol (25.0% vs. 26.7%, respectively). No cases of ovarian hyperstimulation syndrome (OHSS) were noticed in either group.

AB - This pilot study investigates the role of luteal supplementation with recombinant LH in an attempt to reverse the poor reproductive outcome previously noticed after GnRH-agonist triggering of final oocyte maturation for IVF. Similar implantation rates were achieved with the novel recombinant LH luteal supplementation scheme compared with the standard luteal P protocol (25.0% vs. 26.7%, respectively). No cases of ovarian hyperstimulation syndrome (OHSS) were noticed in either group.

KW - Adult

KW - Chorionic Gonadotropin

KW - Drug Therapy, Combination

KW - Female

KW - Fertilization in Vitro

KW - Gonadotropin-Releasing Hormone/agonists

KW - Humans

KW - Luteinizing Hormone/administration & dosage

KW - Ovulation/drug effects

KW - Ovulation Induction/methods

KW - Pilot Projects

KW - Pregnancy

KW - Pregnancy Rate

KW - Recombinant Proteins/administration & dosage

U2 - 10.1016/j.fertnstert.2010.09.023

DO - 10.1016/j.fertnstert.2010.09.023

M3 - Article

C2 - 20979997

SN - 0015-0282

VL - 95

SP - 1174

EP - 1177

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 3

ER -

Papanikolaou EG, Verpoest W, Fatemi H, Tarlatzis B, Devroey P, Tournaye H. A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering: a randomized prospective proof of concept study. Fertility and Sterility. 2011 Mar 1;95(3):1174-1177. doi: 10.1016/j.fertnstert.2010.09.023