A new miniature fiber oxygenator for small animal cardiopulmonary bypass

Ralph J.F. Houston; Fellery De Lange; Cor J. Kalkman

doi:10.1007/978-1-4757-6125-2_44

A new miniature fiber oxygenator for small animal cardiopulmonary bypass

Ralph J.F. Houston^*, Fellery De Lange, Cor J. Kalkman

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

Neurocognitive decline following cardiac surgery is an increasing problem, particularly affecting older patients. The use of cardiopulmonary bypass is a suspected cause. Research into pathophysiology and possible preventive measures requires the use of an animal model. Commercial oxygenators are too large and expensive for use in small animals. We describe a fiber oxygenator scaled for use in the rat. In vitro and in vivo testing show that it is able to support full gas exchange in this size of animal, and causes no allergic or toxic reactions.

Original language	English
Pages (from-to)	313-316
Number of pages	4
Journal	Advances in Experimental Medicine and Biology
Volume	540
DOIs	https://doi.org/10.1007/978-1-4757-6125-2_44
Publication status	Published - 2003

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abstract = "Neurocognitive decline following cardiac surgery is an increasing problem, particularly affecting older patients. The use of cardiopulmonary bypass is a suspected cause. Research into pathophysiology and possible preventive measures requires the use of an animal model. Commercial oxygenators are too large and expensive for use in small animals. We describe a fiber oxygenator scaled for use in the rat. In vitro and in vivo testing show that it is able to support full gas exchange in this size of animal, and causes no allergic or toxic reactions.",

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AB - Neurocognitive decline following cardiac surgery is an increasing problem, particularly affecting older patients. The use of cardiopulmonary bypass is a suspected cause. Research into pathophysiology and possible preventive measures requires the use of an animal model. Commercial oxygenators are too large and expensive for use in small animals. We describe a fiber oxygenator scaled for use in the rat. In vitro and in vivo testing show that it is able to support full gas exchange in this size of animal, and causes no allergic or toxic reactions.

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A new miniature fiber oxygenator for small animal cardiopulmonary bypass

Abstract

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