Abstract
Currently, pressure ulcer preventive strategies focus mainly on pressure redistribution. Little attention is paid to reduce the harmful effects of shear-force, because little is known about pathophysiological aspects of shear-force. Even today, no method to measure the effects of shear-force on the skin is available. Therefore, the aim of this study was to investigate the response to shear-forces in terms of analyzing a noninvasive biomarker and reactive hyperemic parameter measured at the skin of healthy participants. A physical model was developed to produce a combination of pressure and shear or pressure alone on the skin. Ten healthy male participants were included and pressure (3.9 kPa) and a combined loading of pressure and shear (2.4 kPa?+?14.5 N) was applied at the volar aspect of the forearms for 15 and 30 minutes. A Sebutape sample was used to collect IL-1? and total protein (TP) noninvasively. The reactive hyperemic parameter was derived from a laser Doppler flowmeter. The increase in IL-1?/TP-ratio after a combined loading of pressure and shear for 30 minutes of 6.2?±?2.5 was significantly higher compared with all other test conditions (p?
| Original language | English |
|---|---|
| Pages (from-to) | 885-890 |
| Number of pages | 6 |
| Journal | Wound Repair and Regeneration |
| Volume | 23 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Nov 2015 |
| Externally published | Yes |