A new fully covered metal stent with anti-migration features for the treatment of malignant dysphagia

D. Walter; M.W. van den Berg; J.E. van Hooft; H. Boot; R.C.H. Scheffer; F.P. Vleggaar; P.D. Siersema

doi:10.1055/s-0034-1377632

A new fully covered metal stent with anti-migration features for the treatment of malignant dysphagia

D. Walter, M.W. van den Berg, J.E. van Hooft, H. Boot, R.C.H. Scheffer, F.P. Vleggaar, P.D. Siersema

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND AND STUDY AIMS: A new esophageal stent with two anti-migration features was developed to minimize migration. The aim of this study was to evaluate the clinical efficacy and safety of this stent in patients with malignant dysphagia.

PATIENTS AND METHODS: A total of 40 patients with dysphagia due to a malignant obstruction of the esophagus were prospectively enrolled in this cohort study.

RESULTS: Stent placement was technically successful in 39 patients (98 %). The median dysphagia-free time after stent placement was 220 days (95 % confidence interval 94 - 345 days). Nine patients (23 %) experienced recurrent dysphagia due to tissue overgrowth (n = 2), stent fracture (n = 1), and partial (n = 5) or complete (n = 1) stent migration. A total of 16 serious adverse events occurred in 14 patients (36 %), with hemorrhage (n = 3) and severe nausea or vomiting (n = 3) being the most common causes.

CONCLUSIONS: This new stent design was effective for the palliation of malignant dysphagia and had a low rate of recurrent dysphagia. However, despite the anti-migration features, stent migration was still a major cause of recurrent dysphagia. Furthermore, treatment was associated with a high adverse event rate. Dutch Trial Registration (NTR 3313).

Original language	English
Pages (from-to)	1101-1105
Number of pages	5
Journal	Endoscopy
Volume	46
Issue number	12
DOIs	https://doi.org/10.1055/s-0034-1377632
Publication status	Published - Dec 2014

Keywords

Aged
Deglutition Disorders
Esophageal Neoplasms
Esophageal Stenosis
Esophagectomy
Female
Follow-Up Studies
Foreign-Body Migration
Humans
Male
Prospective Studies
Prosthesis Design
Stents
Treatment Outcome

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title = "A new fully covered metal stent with anti-migration features for the treatment of malignant dysphagia",

abstract = "BACKGROUND AND STUDY AIMS: A new esophageal stent with two anti-migration features was developed to minimize migration. The aim of this study was to evaluate the clinical efficacy and safety of this stent in patients with malignant dysphagia.PATIENTS AND METHODS: A total of 40 patients with dysphagia due to a malignant obstruction of the esophagus were prospectively enrolled in this cohort study.RESULTS: Stent placement was technically successful in 39 patients (98 \%). The median dysphagia-free time after stent placement was 220 days (95 \% confidence interval 94 - 345 days). Nine patients (23 \%) experienced recurrent dysphagia due to tissue overgrowth (n = 2), stent fracture (n = 1), and partial (n = 5) or complete (n = 1) stent migration. A total of 16 serious adverse events occurred in 14 patients (36 \%), with hemorrhage (n = 3) and severe nausea or vomiting (n = 3) being the most common causes.CONCLUSIONS: This new stent design was effective for the palliation of malignant dysphagia and had a low rate of recurrent dysphagia. However, despite the anti-migration features, stent migration was still a major cause of recurrent dysphagia. Furthermore, treatment was associated with a high adverse event rate. Dutch Trial Registration (NTR 3313).",

keywords = "Aged, Deglutition Disorders, Esophageal Neoplasms, Esophageal Stenosis, Esophagectomy, Female, Follow-Up Studies, Foreign-Body Migration, Humans, Male, Prospective Studies, Prosthesis Design, Stents, Treatment Outcome",

author = "D. Walter and \{van den Berg\}, M.W. and \{van Hooft\}, J.E. and H. Boot and R.C.H. Scheffer and F.P. Vleggaar and P.D. Siersema",

note = "{\textcopyright} Georg Thieme Verlag KG Stuttgart · New York.",

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month = dec,

doi = "10.1055/s-0034-1377632",

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T1 - A new fully covered metal stent with anti-migration features for the treatment of malignant dysphagia

AU - Walter, D.

AU - van den Berg, M.W.

AU - van Hooft, J.E.

AU - Boot, H.

AU - Scheffer, R.C.H.

AU - Vleggaar, F.P.

AU - Siersema, P.D.

N1 - © Georg Thieme Verlag KG Stuttgart · New York.

PY - 2014/12

Y1 - 2014/12

N2 - BACKGROUND AND STUDY AIMS: A new esophageal stent with two anti-migration features was developed to minimize migration. The aim of this study was to evaluate the clinical efficacy and safety of this stent in patients with malignant dysphagia.PATIENTS AND METHODS: A total of 40 patients with dysphagia due to a malignant obstruction of the esophagus were prospectively enrolled in this cohort study.RESULTS: Stent placement was technically successful in 39 patients (98 %). The median dysphagia-free time after stent placement was 220 days (95 % confidence interval 94 - 345 days). Nine patients (23 %) experienced recurrent dysphagia due to tissue overgrowth (n = 2), stent fracture (n = 1), and partial (n = 5) or complete (n = 1) stent migration. A total of 16 serious adverse events occurred in 14 patients (36 %), with hemorrhage (n = 3) and severe nausea or vomiting (n = 3) being the most common causes.CONCLUSIONS: This new stent design was effective for the palliation of malignant dysphagia and had a low rate of recurrent dysphagia. However, despite the anti-migration features, stent migration was still a major cause of recurrent dysphagia. Furthermore, treatment was associated with a high adverse event rate. Dutch Trial Registration (NTR 3313).

AB - BACKGROUND AND STUDY AIMS: A new esophageal stent with two anti-migration features was developed to minimize migration. The aim of this study was to evaluate the clinical efficacy and safety of this stent in patients with malignant dysphagia.PATIENTS AND METHODS: A total of 40 patients with dysphagia due to a malignant obstruction of the esophagus were prospectively enrolled in this cohort study.RESULTS: Stent placement was technically successful in 39 patients (98 %). The median dysphagia-free time after stent placement was 220 days (95 % confidence interval 94 - 345 days). Nine patients (23 %) experienced recurrent dysphagia due to tissue overgrowth (n = 2), stent fracture (n = 1), and partial (n = 5) or complete (n = 1) stent migration. A total of 16 serious adverse events occurred in 14 patients (36 %), with hemorrhage (n = 3) and severe nausea or vomiting (n = 3) being the most common causes.CONCLUSIONS: This new stent design was effective for the palliation of malignant dysphagia and had a low rate of recurrent dysphagia. However, despite the anti-migration features, stent migration was still a major cause of recurrent dysphagia. Furthermore, treatment was associated with a high adverse event rate. Dutch Trial Registration (NTR 3313).

KW - Aged

KW - Deglutition Disorders

KW - Esophageal Neoplasms

KW - Esophageal Stenosis

KW - Esophagectomy

KW - Female

KW - Follow-Up Studies

KW - Foreign-Body Migration

KW - Humans

KW - Male

KW - Prospective Studies

KW - Prosthesis Design

KW - Stents

KW - Treatment Outcome

U2 - 10.1055/s-0034-1377632

DO - 10.1055/s-0034-1377632

M3 - Article

C2 - 25268307

SN - 0013-726X

VL - 46

SP - 1101

EP - 1105

JO - Endoscopy

JF - Endoscopy

IS - 12

ER -

A new fully covered metal stent with anti-migration features for the treatment of malignant dysphagia

Abstract

Keywords

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