A metabolomic study of preterm and term human and formula milk by proton MRS analysis: preliminary results

Mariangela Longini; Maria Luisa Tataranno; Fabrizio Proietti; Mario Tortoriello; Elisa Belvisi; Antonio Vivi; Maria Tassini; Serafina Perrone; Giuseppe Buonocore

doi:10.3109/14767058.2014.955958

A metabolomic study of preterm and term human and formula milk by proton MRS analysis: preliminary results

Mariangela Longini, Maria Luisa Tataranno, Fabrizio Proietti, Mario Tortoriello, Elisa Belvisi, Antonio Vivi, Maria Tassini, Serafina Perrone, Giuseppe Buonocore^*

^*Corresponding author for this work

Birth Center Neonatology - Medical

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To investigate changes in global metabolic profile between: 1 - breast milk and formula milk, 2 - breast milk from mothers delivering at different gestational age (GA) collected within one week from delivery, and then week by week until term equivalent age.

METHODS: Proton magnetic resonance spectroscopy (MRS) was used to analyze the water-soluble and lipid fractions extracted from 50 milk samples, 46 human milk at different GA, from 23 weeks of gestation until term equivalent age and four different formula milks.

RESULTS: The formula milk for premature infants was the most similar to breast milk of preterm babies. Breast milk showed higher lactose concentrations than formula milk, that conversely presented higher galactose 1-phosphate and maltose concentrations. Mother's milk of very preterm babies (23-25 wks of GA) showed a different metabolic profile from preterm infants ≥29 wks of GA with a subsequent trend to similarity around the 30th week of post-natal age. Breast milk from preterm infants of 29-34 wks, collected up to 40 wks of post-natal age showed a temporal change over the first three weeks of lactation, approaching to zero with the achievement of term age.

CONCLUSIONS: Metabolome is a promising tool to study human and artificial milk global metabolic profile.

Original language	English
Pages (from-to)	27-33
Number of pages	7
Journal	Journal of Maternal-fetal & Neonatal Medicine
Volume	27 Suppl 2
DOIs	https://doi.org/10.3109/14767058.2014.955958
Publication status	Published - Oct 2014

Keywords

Animals
Female
Humans
Infant Formula/chemistry
Infant, Newborn
Infant, Premature
Metabolomics/methods
Milk/chemistry
Milk, Human/chemistry
Principal Component Analysis
Proton Magnetic Resonance Spectroscopy
Term Birth

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10.3109/14767058.2014.955958

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@article{b207e28c85984a3f95615dd7bcb1e287,

title = "A metabolomic study of preterm and term human and formula milk by proton MRS analysis: preliminary results",

abstract = "OBJECTIVE: To investigate changes in global metabolic profile between: 1 - breast milk and formula milk, 2 - breast milk from mothers delivering at different gestational age (GA) collected within one week from delivery, and then week by week until term equivalent age.METHODS: Proton magnetic resonance spectroscopy (MRS) was used to analyze the water-soluble and lipid fractions extracted from 50 milk samples, 46 human milk at different GA, from 23 weeks of gestation until term equivalent age and four different formula milks.RESULTS: The formula milk for premature infants was the most similar to breast milk of preterm babies. Breast milk showed higher lactose concentrations than formula milk, that conversely presented higher galactose 1-phosphate and maltose concentrations. Mother's milk of very preterm babies (23-25 wks of GA) showed a different metabolic profile from preterm infants ≥29 wks of GA with a subsequent trend to similarity around the 30th week of post-natal age. Breast milk from preterm infants of 29-34 wks, collected up to 40 wks of post-natal age showed a temporal change over the first three weeks of lactation, approaching to zero with the achievement of term age.CONCLUSIONS: Metabolome is a promising tool to study human and artificial milk global metabolic profile.",

keywords = "Animals, Female, Humans, Infant Formula/chemistry, Infant, Newborn, Infant, Premature, Metabolomics/methods, Milk/chemistry, Milk, Human/chemistry, Principal Component Analysis, Proton Magnetic Resonance Spectroscopy, Term Birth",

author = "Mariangela Longini and Tataranno, {Maria Luisa} and Fabrizio Proietti and Mario Tortoriello and Elisa Belvisi and Antonio Vivi and Maria Tassini and Serafina Perrone and Giuseppe Buonocore",

year = "2014",

month = oct,

doi = "10.3109/14767058.2014.955958",

language = "English",

volume = "27 Suppl 2",

pages = "27--33",

journal = "Journal of Maternal-fetal & Neonatal Medicine",

issn = "1476-7058",

publisher = "Informa Healthcare",

}

TY - JOUR

T1 - A metabolomic study of preterm and term human and formula milk by proton MRS analysis

T2 - preliminary results

AU - Longini, Mariangela

AU - Tataranno, Maria Luisa

AU - Proietti, Fabrizio

AU - Tortoriello, Mario

AU - Belvisi, Elisa

AU - Vivi, Antonio

AU - Tassini, Maria

AU - Perrone, Serafina

AU - Buonocore, Giuseppe

PY - 2014/10

Y1 - 2014/10

N2 - OBJECTIVE: To investigate changes in global metabolic profile between: 1 - breast milk and formula milk, 2 - breast milk from mothers delivering at different gestational age (GA) collected within one week from delivery, and then week by week until term equivalent age.METHODS: Proton magnetic resonance spectroscopy (MRS) was used to analyze the water-soluble and lipid fractions extracted from 50 milk samples, 46 human milk at different GA, from 23 weeks of gestation until term equivalent age and four different formula milks.RESULTS: The formula milk for premature infants was the most similar to breast milk of preterm babies. Breast milk showed higher lactose concentrations than formula milk, that conversely presented higher galactose 1-phosphate and maltose concentrations. Mother's milk of very preterm babies (23-25 wks of GA) showed a different metabolic profile from preterm infants ≥29 wks of GA with a subsequent trend to similarity around the 30th week of post-natal age. Breast milk from preterm infants of 29-34 wks, collected up to 40 wks of post-natal age showed a temporal change over the first three weeks of lactation, approaching to zero with the achievement of term age.CONCLUSIONS: Metabolome is a promising tool to study human and artificial milk global metabolic profile.

AB - OBJECTIVE: To investigate changes in global metabolic profile between: 1 - breast milk and formula milk, 2 - breast milk from mothers delivering at different gestational age (GA) collected within one week from delivery, and then week by week until term equivalent age.METHODS: Proton magnetic resonance spectroscopy (MRS) was used to analyze the water-soluble and lipid fractions extracted from 50 milk samples, 46 human milk at different GA, from 23 weeks of gestation until term equivalent age and four different formula milks.RESULTS: The formula milk for premature infants was the most similar to breast milk of preterm babies. Breast milk showed higher lactose concentrations than formula milk, that conversely presented higher galactose 1-phosphate and maltose concentrations. Mother's milk of very preterm babies (23-25 wks of GA) showed a different metabolic profile from preterm infants ≥29 wks of GA with a subsequent trend to similarity around the 30th week of post-natal age. Breast milk from preterm infants of 29-34 wks, collected up to 40 wks of post-natal age showed a temporal change over the first three weeks of lactation, approaching to zero with the achievement of term age.CONCLUSIONS: Metabolome is a promising tool to study human and artificial milk global metabolic profile.

KW - Animals

KW - Female

KW - Humans

KW - Infant Formula/chemistry

KW - Infant, Newborn

KW - Infant, Premature

KW - Metabolomics/methods

KW - Milk/chemistry

KW - Milk, Human/chemistry

KW - Principal Component Analysis

KW - Proton Magnetic Resonance Spectroscopy

KW - Term Birth

U2 - 10.3109/14767058.2014.955958

DO - 10.3109/14767058.2014.955958

M3 - Article

C2 - 25284174

SN - 1476-7058

VL - 27 Suppl 2

SP - 27

EP - 33

JO - Journal of Maternal-fetal & Neonatal Medicine

JF - Journal of Maternal-fetal & Neonatal Medicine

ER -

A metabolomic study of preterm and term human and formula milk by proton MRS analysis: preliminary results

Abstract

Keywords

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