TY - GEN
T1 - A longitudinal study of the evolution of the central sulcus’ shape in preterm infants using manifold learning
AU - de Vareilles, Héloïse
AU - Sun, Zhongyi
AU - Benders, Manon
AU - Fischer, Clara
AU - Leroy, François
AU - de Vries, Linda
AU - Groenendaal, Floris
AU - Rivière, Denis
AU - Dubois, Jessica
AU - Mangin, Jean François
N1 - Funding Information:
Keywords: Central sulcus · Preterm infants · Cortical development · Brain MRI Supported by the Human Brain Project under the 785907 (SGA2), and by the FRM DIC20161236445.
Publisher Copyright:
© 2019, Springer Nature Switzerland AG.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Cortical folding in humans is different for every individual, and is associated with functional specificities. It forms mainly during the last trimester of pregnancy, hence its development lacks description, especially in a longitudinal way. To cope with this issue, this study focused on the evolution of the central sulcus’ variability of 71 preterm infants studied longitudinally with MRI at 30 and 40 weeks (w) postmenstrual age (PMA). Our aim was to investigate the main shape characteristics and whether they are encoded early on or appear closer to term birth. We captured shape dissimilarity between the sulci using a distance matrix after pairwise co-registration using an Iterative Closest Point algorithm. We applied non-linear dimensionality reduction to this matrix using the Isomap algorithm in order to capture the most discriminative shape features among the central sulci. We characterized the three most discriminative features over the group, and found that the sulci evolved consistently from a given feature at 30w PMA to the 40w PMA equivalent feature. We incidentally captured a feature that could coincide with the most discriminative adult feature, both visually and by its asymmetry in left and right sulcal distribution. These results captured the main shape features of the central sulcus in preterm infants and suggest that they are already encoded at 30w PMA.
AB - Cortical folding in humans is different for every individual, and is associated with functional specificities. It forms mainly during the last trimester of pregnancy, hence its development lacks description, especially in a longitudinal way. To cope with this issue, this study focused on the evolution of the central sulcus’ variability of 71 preterm infants studied longitudinally with MRI at 30 and 40 weeks (w) postmenstrual age (PMA). Our aim was to investigate the main shape characteristics and whether they are encoded early on or appear closer to term birth. We captured shape dissimilarity between the sulci using a distance matrix after pairwise co-registration using an Iterative Closest Point algorithm. We applied non-linear dimensionality reduction to this matrix using the Isomap algorithm in order to capture the most discriminative shape features among the central sulci. We characterized the three most discriminative features over the group, and found that the sulci evolved consistently from a given feature at 30w PMA to the 40w PMA equivalent feature. We incidentally captured a feature that could coincide with the most discriminative adult feature, both visually and by its asymmetry in left and right sulcal distribution. These results captured the main shape features of the central sulcus in preterm infants and suggest that they are already encoded at 30w PMA.
KW - Brain MRI
KW - Central sulcus
KW - Cortical development
KW - Preterm infants
UR - http://www.scopus.com/inward/record.url?scp=85075730610&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-32875-7_16
DO - 10.1007/978-3-030-32875-7_16
M3 - Conference contribution
AN - SCOPUS:85075730610
SN - 9783030328740
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 143
EP - 152
BT - Smart Ultrasound Imaging and Perinatal, Preterm and Paediatric Image Analysis - 1st International Workshop, SUSI 2019, and 4th International Workshop, PIPPI 2019, Held in Conjunction with MICCAI 2019, Proceedings
A2 - Wang, Qian
A2 - Gomez, Alberto
A2 - Hutter, Jana
A2 - Gomez, Alberto
A2 - Zimmer, Veronika
A2 - Hutter, Jana
A2 - Robinson, Emma
A2 - Christiaens, Daan
A2 - Melbourne, Andrew
A2 - McLeod, Kristin
A2 - Zettinig, Oliver
A2 - Licandro, Roxane
A2 - Turk, Esra Abaci
PB - Springer
T2 - 1st International Workshop on Smart Ultrasound Imaging, SUSI 2019, and the 4th International Workshop on Preterm, Perinatal and Paediatric Image Analysis, PIPPI 2019, held in conjunction with the 22nd International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2019
Y2 - 17 October 2019 through 17 October 2019
ER -