A Long-Distance Chromatin Affair

Annette Denker; Wouter de Laat

doi:10.1016/j.cell.2015.08.022

A Long-Distance Chromatin Affair

Annette Denker, Wouter de Laat

Cancer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Changes in transcription factor binding sequences result in correlated changes in chromatin composition locally and at sites hundreds of kilobases away. New studies demonstrate that this concordance is mediated via spatial chromatin interactions that constitute regulatory modules of the human genome.

Original language	English
Pages (from-to)	942-3
Number of pages	2
Journal	Cell
Volume	162
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2015.08.022
Publication status	Published - 27 Aug 2015

Keywords

Chromatin
Chromosomes, Human
Female
Gene Expression Regulation
Genetic Variation
Genome, Human
Human Genome Project
Humans
Male

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10.1016/j.cell.2015.08.022

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title = "A Long-Distance Chromatin Affair",

abstract = "Changes in transcription factor binding sequences result in correlated changes in chromatin composition locally and at sites hundreds of kilobases away. New studies demonstrate that this concordance is mediated via spatial chromatin interactions that constitute regulatory modules of the human genome.",

keywords = "Chromatin, Chromosomes, Human, Female, Gene Expression Regulation, Genetic Variation, Genome, Human, Human Genome Project, Humans, Male",

author = "Annette Denker and {de Laat}, Wouter",

year = "2015",

month = aug,

day = "27",

doi = "10.1016/j.cell.2015.08.022",

language = "English",

volume = "162",

pages = "942--3",

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T1 - A Long-Distance Chromatin Affair

AU - Denker, Annette

AU - de Laat, Wouter

PY - 2015/8/27

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N2 - Changes in transcription factor binding sequences result in correlated changes in chromatin composition locally and at sites hundreds of kilobases away. New studies demonstrate that this concordance is mediated via spatial chromatin interactions that constitute regulatory modules of the human genome.

AB - Changes in transcription factor binding sequences result in correlated changes in chromatin composition locally and at sites hundreds of kilobases away. New studies demonstrate that this concordance is mediated via spatial chromatin interactions that constitute regulatory modules of the human genome.

KW - Chromatin

KW - Chromosomes, Human

KW - Female

KW - Gene Expression Regulation

KW - Genetic Variation

KW - Genome, Human

KW - Human Genome Project

KW - Humans

KW - Male

U2 - 10.1016/j.cell.2015.08.022

DO - 10.1016/j.cell.2015.08.022

M3 - Article

C2 - 26317462

SN - 0092-8674

VL - 162

SP - 942

EP - 943

JO - Cell

JF - Cell

IS - 5

ER -

A Long-Distance Chromatin Affair

Abstract

Keywords

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