A layered approach of response to treatment in Psoriasis and Psoriatic Arthritis

Nanette Vincken

doi:10.33540/2029

A layered approach of response to treatment in Psoriasis and Psoriatic Arthritis

Nanette Vincken

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

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Abstract

Psoriasis is a chronic skin condition affecting approximately 60 million people worldwide, significantly impacting their lives. Its origins are complex, involving genetic and environmental factors, as well as immune system issues. Treatment is challenging and requires a multidisciplinary approach. Tofacitinib, a new medicine, appears effective in patients with higher IFN-γ levels. Systemic corticosteroids may be a safe option, contrary to previous concerns. The research also sheds light on predictive factors for methotrexate treatment in psoriatic arthritis and atopic eczema. These findings could pave the way for personalized treatments and contribute to understanding complex conditions like psoriasis and psoriatic arthritis.

Original language	English
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	van Laar, Jaap, Primary supervisor Angiolilli, Chiara, Co-supervisor Welsing, Paco, Co-supervisor
Award date	20 Dec 2023
Publisher	Utrecht University
Print ISBNs	978-94-6483-489-5
DOIs	https://doi.org/10.33540/2029
Publication status	Published - 20 Dec 2023

Keywords

psoriasis
psoriatic arthritis
personalized medicine
mDC
tofacitinib
IL23

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https://dspace.library.uu.nl/handle/1874/433421

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title = "A layered approach of response to treatment in Psoriasis and Psoriatic Arthritis",

abstract = "Psoriasis is a chronic skin condition affecting approximately 60 million people worldwide, significantly impacting their lives. Its origins are complex, involving genetic and environmental factors, as well as immune system issues. Treatment is challenging and requires a multidisciplinary approach. Tofacitinib, a new medicine, appears effective in patients with higher IFN-γ levels. Systemic corticosteroids may be a safe option, contrary to previous concerns. The research also sheds light on predictive factors for methotrexate treatment in psoriatic arthritis and atopic eczema. These findings could pave the way for personalized treatments and contribute to understanding complex conditions like psoriasis and psoriatic arthritis.",

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AB - Psoriasis is a chronic skin condition affecting approximately 60 million people worldwide, significantly impacting their lives. Its origins are complex, involving genetic and environmental factors, as well as immune system issues. Treatment is challenging and requires a multidisciplinary approach. Tofacitinib, a new medicine, appears effective in patients with higher IFN-γ levels. Systemic corticosteroids may be a safe option, contrary to previous concerns. The research also sheds light on predictive factors for methotrexate treatment in psoriatic arthritis and atopic eczema. These findings could pave the way for personalized treatments and contribute to understanding complex conditions like psoriasis and psoriatic arthritis.

KW - psoriasis

KW - psoriatic arthritis

KW - personalized medicine

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KW - tofacitinib

KW - IL23

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SN - 978-94-6483-489-5

PB - Utrecht University

ER -

A layered approach of response to treatment in Psoriasis and Psoriatic Arthritis

Abstract

Keywords

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