A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13

Reynir Arngrímsson; Sigrún Siguröardóttir; Michael L. Frigge; Ragnheiöur I. Bjarnadóttir; Thorlákur Jónsson; Hreinn Stefánsson; Ásdís Baldursdóttir; Anna S. Einarsdóttir; Birgir Palsson; Steinunn Snorradóttir; A. M.A. Lachmeijer; Dan Nicolae; Augustine Kong; Birkir Thor Bragason; Jeffrey R. Gulcher; Reynir Tómas Geirsson; Kári Stefánsson

doi:10.1093/hmg/8.9.1799

A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13

Reynir Arngrímsson^*, Sigrún Siguröardóttir, Michael L. Frigge, Ragnheiöur I. Bjarnadóttir, Thorlákur Jónsson, Hreinn Stefánsson, Ásdís Baldursdóttir, Anna S. Einarsdóttir, Birgir Palsson, Steinunn Snorradóttir, A. M.A. Lachmeijer, Dan Nicolae, Augustine Kong, Birkir Thor Bragason, Jeffrey R. Gulcher, Reynir Tómas Geirsson, Kári Stefánsson

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Pre-eclampsia is a common and serious disease and a major cause of maternal and infant mortality. Antenatal care systems world-wide screen for signs of the disease such as hypertension and proteinuria. Unlike most other human disorders it impacts two individuals, the mother and the child, both of whom can be severely affected. The pathophysiology of the disorder is incompletely understood, but familial clustering of the disease is apparent. Here we report the results of a genome-wide screen of Icelandic families representing 343 affected women. Including those patients with non-proteinuric pre-eclampsia (gestational hypertension), proteinuric pre-eclampsia and eclampsia, we detected a significant locus on 2p13 with a lod score of 4.70 (single point P < 3.49 x 10^-6). This is the first reported locus for pre-eclampsia meeting the criteria for genome-wide significance.

Original language	English
Pages (from-to)	1799-1805
Number of pages	7
Journal	Human molecular genetics
Volume	8
Issue number	9
DOIs	https://doi.org/10.1093/hmg/8.9.1799
Publication status	Published - 1999
Externally published	Yes

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Arngrímsson, R., Siguröardóttir, S., Frigge, M. L., Bjarnadóttir, R. I., Jónsson, T., Stefánsson, H., Baldursdóttir, Á., Einarsdóttir, A. S., Palsson, B., Snorradóttir, S., Lachmeijer, A. M. A., Nicolae, D., Kong, A., Bragason, B. T., Gulcher, J. R., Geirsson, R. T., & Stefánsson, K. (1999). A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. Human molecular genetics, 8(9), 1799-1805. https://doi.org/10.1093/hmg/8.9.1799

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title = "A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13",

abstract = "Pre-eclampsia is a common and serious disease and a major cause of maternal and infant mortality. Antenatal care systems world-wide screen for signs of the disease such as hypertension and proteinuria. Unlike most other human disorders it impacts two individuals, the mother and the child, both of whom can be severely affected. The pathophysiology of the disorder is incompletely understood, but familial clustering of the disease is apparent. Here we report the results of a genome-wide screen of Icelandic families representing 343 affected women. Including those patients with non-proteinuric pre-eclampsia (gestational hypertension), proteinuric pre-eclampsia and eclampsia, we detected a significant locus on 2p13 with a lod score of 4.70 (single point P < 3.49 x 10-6). This is the first reported locus for pre-eclampsia meeting the criteria for genome-wide significance.",

author = "Reynir Arngr{\'i}msson and Sigr{\'u}n Sigur{\"o}ard{\'o}ttir and Frigge, \{Michael L.\} and Bjarnad{\'o}ttir, \{Ragnhei{\"o}ur I.\} and Thorl{\'a}kur J{\'o}nsson and Hreinn Stef{\'a}nsson and {\'A}sd{\'i}s Baldursd{\'o}ttir and Einarsd{\'o}ttir, \{Anna S.\} and Birgir Palsson and Steinunn Snorrad{\'o}ttir and Lachmeijer, \{A. M.A.\} and Dan Nicolae and Augustine Kong and Bragason, \{Birkir Thor\} and Gulcher, \{Jeffrey R.\} and Geirsson, \{Reynir T{\'o}mas\} and K{\'a}ri Stef{\'a}nsson",

year = "1999",

doi = "10.1093/hmg/8.9.1799",

language = "English",

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Arngrímsson, R, Siguröardóttir, S, Frigge, ML, Bjarnadóttir, RI, Jónsson, T, Stefánsson, H, Baldursdóttir, Á, Einarsdóttir, AS, Palsson, B, Snorradóttir, S, Lachmeijer, AMA, Nicolae, D, Kong, A, Bragason, BT, Gulcher, JR, Geirsson, RT & Stefánsson, K 1999, 'A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13', Human molecular genetics, vol. 8, no. 9, pp. 1799-1805. https://doi.org/10.1093/hmg/8.9.1799

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T1 - A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13

AU - Arngrímsson, Reynir

AU - Siguröardóttir, Sigrún

AU - Frigge, Michael L.

AU - Bjarnadóttir, Ragnheiöur I.

AU - Jónsson, Thorlákur

AU - Stefánsson, Hreinn

AU - Baldursdóttir, Ásdís

AU - Einarsdóttir, Anna S.

AU - Palsson, Birgir

AU - Snorradóttir, Steinunn

AU - Lachmeijer, A. M.A.

AU - Nicolae, Dan

AU - Kong, Augustine

AU - Bragason, Birkir Thor

AU - Gulcher, Jeffrey R.

AU - Geirsson, Reynir Tómas

AU - Stefánsson, Kári

PY - 1999

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AB - Pre-eclampsia is a common and serious disease and a major cause of maternal and infant mortality. Antenatal care systems world-wide screen for signs of the disease such as hypertension and proteinuria. Unlike most other human disorders it impacts two individuals, the mother and the child, both of whom can be severely affected. The pathophysiology of the disorder is incompletely understood, but familial clustering of the disease is apparent. Here we report the results of a genome-wide screen of Icelandic families representing 343 affected women. Including those patients with non-proteinuric pre-eclampsia (gestational hypertension), proteinuric pre-eclampsia and eclampsia, we detected a significant locus on 2p13 with a lod score of 4.70 (single point P < 3.49 x 10-6). This is the first reported locus for pre-eclampsia meeting the criteria for genome-wide significance.

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SP - 1799

EP - 1805

JO - Human molecular genetics

JF - Human molecular genetics

IS - 9

ER -

A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13

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