@article{e0f7e76e5f0c43df9d4549a742e309bc,
title = "A Genome-Wide Association Study of Outcome After Aneurysmal Subarachnoid Haemorrhage: Discovery Analysis",
abstract = "Candidate gene studies have identified genetic variants associated with clinical outcomes following aneurysmal subarachnoid haemorrhage (aSAH), but no genome-wide association studies have been performed to date. Here we report the results of the discovery phase of a two-stage genome-wide meta-analysis of outcome after aSAH. We identified 157 independent loci harbouring 756 genetic variants associated with outcome after aSAH (p < 1 × 10 -4), which require validation. A single variant (rs12949158), in SPNS2, achieved genome-wide significance (p = 4.29 × 10 -8) implicating sphingosine-1-phosphate signalling in outcome after aSAH. A large multicentre international effort to recruit samples for validation is required and ongoing. Validation of these findings will provide significant insight into the pathophysiology of outcomes after aSAH with potential implications for treatment. ",
keywords = "Genetics, Medical, Outcome assessment, Health care, Stroke, Subarachnoid haemorrhage",
author = "Ben Gaastra and Sheila Alexander and Bakker, {Mark K.} and Hemant Bhagat and Philippe Bijlenga and Blackburn, {Spiros L.} and Collins, {Malie K.} and Sylvain Dor{\'e} and Griessenauer, {Christoph J.} and Philipp Hendrix and Hong, {Eun Pyo} and Hostettler, {Isabel C.} and Henry Houlden and Koji IIhara and Jeon, {Jin Pyeong} and Kim, {Bong Jun} and Jiang Li and Sandrine Morel and Paul Nyquist and Dianxu Ren and Ruigrok, {Ynte M.} and David Werring and Will Tapper and Ian Galea and Diederik Bulters",
note = "Funding Information: This research has been conducted using the UK Biobank Resource under Application Number 49305. The authors acknowledge the use of the IRIDIS High Performance Computing Facility, and associated support services at the University of Southampton, in the completion of this work. We also acknowledge the contributions of the Clinical Research Center, University Hospital and Faculty of Medicine, Geneva. Funding Information: BG is funded by is funded by the Royal College of Surgeons, Society of British Neurological Surgeons, Barrow Foundation and Guarantors of Brain in addition to the Institute for Life Sciences, University of Southampton. DJW, HH and IH received funding for recruitment to the GOSH study and genotyping from the Stroke Association and the UCLH NIHR Biomedical Research Centre. SA received funding for data and sample collection from the National Institute of Nursing Research (R01NR004339). YR received funding from the Netherlands Cardiovascular Research Initiative: An initiative with the support of the Dutch Heart Foundation, CVON2015-08 ERASE and from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (PRYSM, grant agreement No. 852173). PB and SM received funding for the AneuX project from SystemsX.ch; it was evaluated by the Swiss National Science Foundation. SB is supported by NIH Grant (K23NS106054). Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2023",
month = oct,
doi = "10.1007/s12975-022-01095-4",
language = "English",
volume = "14",
pages = "681--687",
journal = "Translational Stroke Research",
issn = "1868-4483",
publisher = "Springer US",
number = "5",
}