A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Joseph Vijai; Zhaoming Wang; Sonja I Berndt; Christine F Skibola; Susan L Slager; Silvia de Sanjose; Mads Melbye; Bengt Glimelius; Paige M Bracci; Lucia Conde; Brenda M Birmann; Sophia S Wang; Angela R Brooks-Wilson; Qing Lan; Paul I W de Bakker; Roel C H Vermeulen; Carol Portlock; Stephen M Ansell; Brian K Link; Jacques Riby; Kari E North; Jian Gu; Henrik Hjalgrim; Wendy Cozen; Nikolaus Becker; Lauren R Teras; John J Spinelli; Jenny Turner; Yawei Zhang; Mark P Purdue; Graham G Giles; Rachel S Kelly; Anne Zeleniuch-Jacquotte; Maria Grazia Ennas; Alain Monnereau; Kimberly A Bertrand; Demetrius Albanes; Tracy Lightfoot; Meredith Yeager; Charles C Chung; Laurie Burdett; Amy Hutchinson; Charles Lawrence; Rebecca Montalvan; Liming Liang; Jinyan Huang; Baoshan Ma; Danylo J Villano; Ann Maria; Marina Corines; Tinu Thomas; Anne J Novak; Ahmet Dogan; Mark Liebow; Carrie A Thompson; Thomas E Witzig; Thomas M Habermann; George J Weiner; Martyn T Smith; Elizabeth A Holly; Rebecca D Jackson; Lesley F Tinker; Yuanqing Ye; Hans-Olov Adami; Karin E Smedby; Anneclaire J De Roos; Patricia Hartge; Lindsay M Morton; Richard K Severson; Yolanda Benavente; Paolo Boffetta; Paul Brennan; Lenka Foretova; Marc Maynadie; James McKay; Anthony Staines; W Ryan Diver; Claire M Vajdic; Bruce K Armstrong; Anne Kricker; Tongzhang Zheng; Theodore R Holford; Gianluca Severi; Paolo Vineis; Giovanni M Ferri; Rosalia Ricco; Lucia Miligi; Jacqueline Clavel; Edward Giovannucci; Peter Kraft; Jarmo Virtamo; Alex Smith; Eleanor Kane; Eve Roman; Brian C H Chiu; Joseph F Fraumeni; Xifeng Wu; James R Cerhan; Kenneth Offit; Stephen J Chanock; Nathaniel Rothman; Alexandra Nieters

doi:10.1038/ncomms6751

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Joseph Vijai
, Zhaoming Wang
, Sonja I Berndt
, Christine F Skibola
, Susan L Slager
, Silvia de Sanjose
, Mads Melbye
, Bengt Glimelius
, Paige M Bracci
, Lucia Conde
, Brenda M Birmann
, Sophia S Wang
, Angela R Brooks-Wilson
, Qing Lan
, Paul I W de Bakker
, Roel C H Vermeulen
, Carol Portlock
, Stephen M Ansell
, Brian K Link
, Jacques Riby

Kari E North, Jian Gu, Henrik Hjalgrim, Wendy Cozen, Nikolaus Becker, Lauren R Teras, John J Spinelli, Jenny Turner, Yawei Zhang, Mark P Purdue, Graham G Giles, Rachel S Kelly, Anne Zeleniuch-Jacquotte, Maria Grazia Ennas, Alain Monnereau, Kimberly A Bertrand, Demetrius Albanes, Tracy Lightfoot, Meredith Yeager, Charles C Chung, Laurie Burdett, Amy Hutchinson, Charles Lawrence, Rebecca Montalvan, Liming Liang, Jinyan Huang, Baoshan Ma, Danylo J Villano, Ann Maria, Marina Corines, Tinu Thomas, Anne J Novak, Ahmet Dogan, Mark Liebow, Carrie A Thompson, Thomas E Witzig, Thomas M Habermann, George J Weiner, Martyn T Smith, Elizabeth A Holly, Rebecca D Jackson, Lesley F Tinker, Yuanqing Ye, Hans-Olov Adami, Karin E Smedby, Anneclaire J De Roos, Patricia Hartge, Lindsay M Morton, Richard K Severson, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadie, James McKay, Anthony Staines, W Ryan Diver, Claire M Vajdic, Bruce K Armstrong, Anne Kricker, Tongzhang Zheng, Theodore R Holford, Gianluca Severi, Paolo Vineis, Giovanni M Ferri, Rosalia Ricco, Lucia Miligi, Jacqueline Clavel, Edward Giovannucci, Peter Kraft, Jarmo Virtamo, Alex Smith, Eleanor Kane, Eve Roman, Brian C H Chiu, Joseph F Fraumeni, Xifeng Wu, James R Cerhan, Kenneth Offit, Stephen J Chanock, Nathaniel Rothman, Alexandra Nieters

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Abstract

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

Original language	English
Article number	5751
Number of pages	7
Journal	Nature Communications [E]
Volume	6
DOIs	https://doi.org/10.1038/ncomms6751
Publication status	Published - 2015

Keywords

Computational Biology
European Continental Ancestry Group
Genome-Wide Association Study
Genotype
Humans
Lymphoma, B-Cell, Marginal Zone
Major Histocompatibility Complex
Membrane Glycoproteins
Polymorphism, Single Nucleotide

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Vijai, J., Wang, Z., Berndt, S. I., Skibola, C. F., Slager, S. L., de Sanjose, S., Melbye, M., Glimelius, B., Bracci, P. M., Conde, L., Birmann, B. M., Wang, S. S., Brooks-Wilson, A. R., Lan, Q., de Bakker, P. I. W., Vermeulen, R. C. H., Portlock, C., Ansell, S. M., Link, B. K., ... Nieters, A. (2015). A genome-wide association study of marginal zone lymphoma shows association to the HLA region. Nature Communications [E], 6, Article 5751. https://doi.org/10.1038/ncomms6751

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title = "A genome-wide association study of marginal zone lymphoma shows association to the HLA region",

abstract = "Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.",

keywords = "Computational Biology, European Continental Ancestry Group, Genome-Wide Association Study, Genotype, Humans, Lymphoma, B-Cell, Marginal Zone, Major Histocompatibility Complex, Membrane Glycoproteins, Polymorphism, Single Nucleotide",

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year = "2015",

doi = "10.1038/ncomms6751",

language = "English",

volume = "6",

journal = "Nature Communications [E]",

issn = "2041-1723",

publisher = "Nature Research",

}

Vijai, J, Wang, Z, Berndt, SI, Skibola, CF, Slager, SL, de Sanjose, S, Melbye, M, Glimelius, B, Bracci, PM, Conde, L, Birmann, BM, Wang, SS, Brooks-Wilson, AR, Lan, Q, de Bakker, PIW, Vermeulen, RCH, Portlock, C, Ansell, SM, Link, BK, Riby, J, North, KE, Gu, J, Hjalgrim, H, Cozen, W, Becker, N, Teras, LR, Spinelli, JJ, Turner, J, Zhang, Y, Purdue, MP, Giles, GG, Kelly, RS, Zeleniuch-Jacquotte, A, Ennas, MG, Monnereau, A, Bertrand, KA, Albanes, D, Lightfoot, T, Yeager, M, Chung, CC, Burdett, L, Hutchinson, A, Lawrence, C, Montalvan, R, Liang, L, Huang, J, Ma, B, Villano, DJ, Maria, A, Corines, M, Thomas, T, Novak, AJ, Dogan, A, Liebow, M, Thompson, CA, Witzig, TE, Habermann, TM, Weiner, GJ, Smith, MT, Holly, EA, Jackson, RD, Tinker, LF, Ye, Y, Adami, H-O, Smedby, KE, De Roos, AJ, Hartge, P, Morton, LM, Severson, RK, Benavente, Y, Boffetta, P, Brennan, P, Foretova, L, Maynadie, M, McKay, J, Staines, A, Diver, WR, Vajdic, CM, Armstrong, BK, Kricker, A, Zheng, T, Holford, TR, Severi, G, Vineis, P, Ferri, GM, Ricco, R, Miligi, L, Clavel, J, Giovannucci, E, Kraft, P, Virtamo, J, Smith, A, Kane, E, Roman, E, Chiu, BCH, Fraumeni, JF, Wu, X, Cerhan, JR, Offit, K, Chanock, SJ, Rothman, N & Nieters, A 2015, 'A genome-wide association study of marginal zone lymphoma shows association to the HLA region', Nature Communications [E], vol. 6, 5751. https://doi.org/10.1038/ncomms6751

TY - JOUR

T1 - A genome-wide association study of marginal zone lymphoma shows association to the HLA region

AU - Vijai, Joseph

AU - Wang, Zhaoming

AU - Berndt, Sonja I

AU - Skibola, Christine F

AU - Slager, Susan L

AU - de Sanjose, Silvia

AU - Melbye, Mads

AU - Glimelius, Bengt

AU - Bracci, Paige M

AU - Conde, Lucia

AU - Birmann, Brenda M

AU - Wang, Sophia S

AU - Brooks-Wilson, Angela R

AU - Lan, Qing

AU - de Bakker, Paul I W

AU - Vermeulen, Roel C H

AU - Portlock, Carol

AU - Ansell, Stephen M

AU - Link, Brian K

AU - Riby, Jacques

AU - North, Kari E

AU - Gu, Jian

AU - Hjalgrim, Henrik

AU - Cozen, Wendy

AU - Becker, Nikolaus

AU - Teras, Lauren R

AU - Spinelli, John J

AU - Turner, Jenny

AU - Zhang, Yawei

AU - Purdue, Mark P

AU - Giles, Graham G

AU - Kelly, Rachel S

AU - Zeleniuch-Jacquotte, Anne

AU - Ennas, Maria Grazia

AU - Monnereau, Alain

AU - Bertrand, Kimberly A

AU - Albanes, Demetrius

AU - Lightfoot, Tracy

AU - Yeager, Meredith

AU - Chung, Charles C

AU - Burdett, Laurie

AU - Hutchinson, Amy

AU - Lawrence, Charles

AU - Montalvan, Rebecca

AU - Liang, Liming

AU - Huang, Jinyan

AU - Ma, Baoshan

AU - Villano, Danylo J

AU - Maria, Ann

AU - Corines, Marina

AU - Thomas, Tinu

AU - Novak, Anne J

AU - Dogan, Ahmet

AU - Liebow, Mark

AU - Thompson, Carrie A

AU - Witzig, Thomas E

AU - Habermann, Thomas M

AU - Weiner, George J

AU - Smith, Martyn T

AU - Holly, Elizabeth A

AU - Jackson, Rebecca D

AU - Tinker, Lesley F

AU - Ye, Yuanqing

AU - Adami, Hans-Olov

AU - Smedby, Karin E

AU - De Roos, Anneclaire J

AU - Hartge, Patricia

AU - Morton, Lindsay M

AU - Severson, Richard K

AU - Benavente, Yolanda

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Foretova, Lenka

AU - Maynadie, Marc

AU - McKay, James

AU - Staines, Anthony

AU - Diver, W Ryan

AU - Vajdic, Claire M

AU - Armstrong, Bruce K

AU - Kricker, Anne

AU - Zheng, Tongzhang

AU - Holford, Theodore R

AU - Severi, Gianluca

AU - Vineis, Paolo

AU - Ferri, Giovanni M

AU - Ricco, Rosalia

AU - Miligi, Lucia

AU - Clavel, Jacqueline

AU - Giovannucci, Edward

AU - Kraft, Peter

AU - Virtamo, Jarmo

AU - Smith, Alex

AU - Kane, Eleanor

AU - Roman, Eve

AU - Chiu, Brian C H

AU - Fraumeni, Joseph F

AU - Wu, Xifeng

AU - Cerhan, James R

AU - Offit, Kenneth

AU - Chanock, Stephen J

AU - Rothman, Nathaniel

AU - Nieters, Alexandra

PY - 2015

Y1 - 2015

N2 - Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

AB - Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

KW - Computational Biology

KW - European Continental Ancestry Group

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Lymphoma, B-Cell, Marginal Zone

KW - Major Histocompatibility Complex

KW - Membrane Glycoproteins

KW - Polymorphism, Single Nucleotide

U2 - 10.1038/ncomms6751

DO - 10.1038/ncomms6751

M3 - Article

C2 - 25569183

SN - 2041-1723

VL - 6

JO - Nature Communications [E]

JF - Nature Communications [E]

M1 - 5751

ER -

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Abstract

Keywords

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