TY - JOUR
T1 - A dual-purpose MRI acquisition to combine 4D-MRI and dynamic contrast-enhanced imaging for abdominal radiotherapy planning
AU - Stemken, Bjorn
AU - Prins, Fieke M.
AU - Bruijnen, Tom
AU - Kerkmeijer, Linda G. W.
AU - Lagendijk, Jan J. W.
AU - van den Ber, Cornelis A. T.
AU - Tijssen, Rob H. N.
N1 - Publisher Copyright:
© 2019 Institute of Physics and Engineering in Medicine.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/3
Y1 - 2019/3
N2 - For successful abdominal radiotherapy it is crucial to have a clear tumor definition and an accurate characterization of the motion. While dynamic contrast-enhanced (DCE) MRI aids tumor visualization, it is often hampered by motion artifacts. 4D-MRI characterizes this motion, but often lacks the contrast to clearly visualize the tumor. This dual requirement is challenging due to time constraints. Here, we propose combining both into a single acquisition by reconstructing the data in various ways in order to achieve both high spatiooral resolution DCE-MRI and accurate 4D-MRI motion estimates. A 5 min T
1 -weigthed DCE acquisition was collected in five renal-cell carcinoma patients and simulated in a digital phantom. Data were acquired continuously using a 3D golden angle radial stack-of-stars acquisition. This enabled three types of reconstruction; (1) a high spatiooral resolution DCE time series, (2) a 5D reconstruction and (3) a contrast-enhanced 4D-MRI for motion characterization. Motion extracted from the 4D- and 5D-MRI was compared with a separately acquired 4D-MRI and additional 2D cine MR imaging. Simulations on XCAT showed that 5D reconstructions severely underestimated motion (), whereas contrast-enhanced 4D-MRI only underestimated motion by . This was confirmed in the in vivo data where motion of the contrast-enhanced 4D-MRI was approximately smaller than the motion in the 2D cine MRI (5.8 mm versus 6.5 mm), but equal to a separately acquired 4D-MRI (5.8 mm versus 5.9 mm). 5D reconstructions underestimated the motion by more than , but minimized respiratory-induced blurring in the contrast enhanced images. DCE time-series demonstrated clear tumor visualization and contrast enhancement throughout the entire field-of-view. DCE- and 4D-MRI can be integrated into a single acquisition that enables different reconstructions with complementary information for abdominal radiotherapy planning and, in an MRI-guided treatment, precise motion information, input for motion models, and rapid feedback on the contrast enhancement.
AB - For successful abdominal radiotherapy it is crucial to have a clear tumor definition and an accurate characterization of the motion. While dynamic contrast-enhanced (DCE) MRI aids tumor visualization, it is often hampered by motion artifacts. 4D-MRI characterizes this motion, but often lacks the contrast to clearly visualize the tumor. This dual requirement is challenging due to time constraints. Here, we propose combining both into a single acquisition by reconstructing the data in various ways in order to achieve both high spatiooral resolution DCE-MRI and accurate 4D-MRI motion estimates. A 5 min T
1 -weigthed DCE acquisition was collected in five renal-cell carcinoma patients and simulated in a digital phantom. Data were acquired continuously using a 3D golden angle radial stack-of-stars acquisition. This enabled three types of reconstruction; (1) a high spatiooral resolution DCE time series, (2) a 5D reconstruction and (3) a contrast-enhanced 4D-MRI for motion characterization. Motion extracted from the 4D- and 5D-MRI was compared with a separately acquired 4D-MRI and additional 2D cine MR imaging. Simulations on XCAT showed that 5D reconstructions severely underestimated motion (), whereas contrast-enhanced 4D-MRI only underestimated motion by . This was confirmed in the in vivo data where motion of the contrast-enhanced 4D-MRI was approximately smaller than the motion in the 2D cine MRI (5.8 mm versus 6.5 mm), but equal to a separately acquired 4D-MRI (5.8 mm versus 5.9 mm). 5D reconstructions underestimated the motion by more than , but minimized respiratory-induced blurring in the contrast enhanced images. DCE time-series demonstrated clear tumor visualization and contrast enhancement throughout the entire field-of-view. DCE- and 4D-MRI can be integrated into a single acquisition that enables different reconstructions with complementary information for abdominal radiotherapy planning and, in an MRI-guided treatment, precise motion information, input for motion models, and rapid feedback on the contrast enhancement.
KW - 4D-MRI
KW - Dynamic contrast ehanced imaging
KW - GRASP
KW - MRI-guided radiotherapy
KW - motion management
KW - radiotherapy treatment planning
KW - renal cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85062596464&partnerID=8YFLogxK
U2 - 10.1088/1361-6560/ab0295
DO - 10.1088/1361-6560/ab0295
M3 - Article
C2 - 30695759
SN - 0031-9155
VL - 64
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
IS - 6
M1 - 06NT02
ER -