TY - JOUR
T1 - A bacterial mutational footprint in colorectal cancer genomes
AU - Rosendahl Huber, Axel
AU - Pleguezuelos-Manzano, Cayetano
AU - Puschhof, Jens
N1 - Funding Information:
Funding information A.R.H., C.P.-M. and J.P. were supported by the Oncode Institute (partly financed by the Dutch Cancer Society). A.R.H. was supported by a VIDI grant from the NWO (no. 016.Vidi.171.023); C.P.-M. and J.P. were supported by the following grants: CRUK OPTIMISTICC (C10674/A27140), the Gravitation project CancerGe-nomiCs.nl, and the Netherlands Organ-on-Chip Initiative (024.003.001) from the Netherlands Organisation for Scientific Research (NWO) funded by the Ministry of Education, Culture and Science of the government of the Netherlands.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Cancer Research UK.
PY - 2021/5/25
Y1 - 2021/5/25
N2 - Changes in the microbiome are associated with the development of colorectal cancer, but causal explanations have been lacking. We recently demonstrated that pks+Escherichia coli induce a specific mutational pattern using intestinal organoids and these mutations are present in the genomes of colorectal cancer. This finding warrants further studies on the microbial role in oncogenic mutation induction, cancer development and future preventive strategies.
AB - Changes in the microbiome are associated with the development of colorectal cancer, but causal explanations have been lacking. We recently demonstrated that pks+Escherichia coli induce a specific mutational pattern using intestinal organoids and these mutations are present in the genomes of colorectal cancer. This finding warrants further studies on the microbial role in oncogenic mutation induction, cancer development and future preventive strategies.
UR - http://www.scopus.com/inward/record.url?scp=85102734434&partnerID=8YFLogxK
U2 - 10.1038/s41416-021-01273-5
DO - 10.1038/s41416-021-01273-5
M3 - Comment/Letter to the editor
C2 - 33742142
AN - SCOPUS:85102734434
SN - 0007-0920
VL - 124
SP - 1751
EP - 1753
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 11
ER -