7 tesla T2-weighted MRI as a tool to improve detection of focal cortical dysplasia

Tim J. Veersema; Pieter van Eijsden; PH Gosselaar; J Hendrikse; Jaco J M Zwanenburg; Wim G M Spliet; Eleonora Aronica; Kees P J Braun; Cyrille H. Ferrier

doi:10.1684/epd.2016.0838

7 tesla T₂-weighted MRI as a tool to improve detection of focal cortical dysplasia

Tim J. Veersema^*, Pieter van Eijsden, PH Gosselaar, J Hendrikse, Jaco J M Zwanenburg, Wim G M Spliet, Eleonora Aronica, Kees P J Braun, Cyrille H. Ferrier

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Focal cortical dysplasia is one of the most common underlying pathologies in patients who undergo surgery for refractory epilepsy. Absence of a MRI-visible lesion necessitates additional diagnostic tests and is a predictor of poor surgical outcome.We describe a series of six patients with refractory epilepsy due to histopathologically-confirmed focal cortical dysplasia, for whom pre-surgical 7 tesla T₂-weighted MRIwas acquired. In four of six patients, T₂ sequences showed areas of marked superficial hypointensity, co-localizing with the epileptogenic lesion. 7 tesla T₂ hypointensities overlying focal cortical dysplasia may represent leptomeningeal venous vascular abnormalities associated with the underlying dysplastic cortex. Adding T₂ sequences to the MRI protocol may aid in the detection of focal cortical dysplasias.

Original language	English
Pages (from-to)	315-323
Number of pages	9
Journal	Epileptic Disorders
Volume	18
Issue number	3
DOIs	https://doi.org/10.1684/epd.2016.0838
Publication status	Published - 1 Sept 2016

Keywords

Cortical localization
Epilepsy
FCD
Magnetic resonance imaging
Susceptibility weighted
Ultra-high field

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10.1684/epd.2016.0838

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title = "7 tesla T2-weighted MRI as a tool to improve detection of focal cortical dysplasia",

abstract = "Focal cortical dysplasia is one of the most common underlying pathologies in patients who undergo surgery for refractory epilepsy. Absence of a MRI-visible lesion necessitates additional diagnostic tests and is a predictor of poor surgical outcome.We describe a series of six patients with refractory epilepsy due to histopathologically-confirmed focal cortical dysplasia, for whom pre-surgical 7 tesla T2-weighted MRIwas acquired. In four of six patients, T2 sequences showed areas of marked superficial hypointensity, co-localizing with the epileptogenic lesion. 7 tesla T2 hypointensities overlying focal cortical dysplasia may represent leptomeningeal venous vascular abnormalities associated with the underlying dysplastic cortex. Adding T2 sequences to the MRI protocol may aid in the detection of focal cortical dysplasias.",

keywords = "Cortical localization, Epilepsy, FCD, Magnetic resonance imaging, Susceptibility weighted, Ultra-high field",

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doi = "10.1684/epd.2016.0838",

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AU - Veersema, Tim J.

AU - van Eijsden, Pieter

AU - Gosselaar, PH

AU - Hendrikse, J

AU - Zwanenburg, Jaco J M

AU - Spliet, Wim G M

AU - Aronica, Eleonora

AU - Braun, Kees P J

AU - Ferrier, Cyrille H.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Focal cortical dysplasia is one of the most common underlying pathologies in patients who undergo surgery for refractory epilepsy. Absence of a MRI-visible lesion necessitates additional diagnostic tests and is a predictor of poor surgical outcome.We describe a series of six patients with refractory epilepsy due to histopathologically-confirmed focal cortical dysplasia, for whom pre-surgical 7 tesla T2-weighted MRIwas acquired. In four of six patients, T2 sequences showed areas of marked superficial hypointensity, co-localizing with the epileptogenic lesion. 7 tesla T2 hypointensities overlying focal cortical dysplasia may represent leptomeningeal venous vascular abnormalities associated with the underlying dysplastic cortex. Adding T2 sequences to the MRI protocol may aid in the detection of focal cortical dysplasias.

AB - Focal cortical dysplasia is one of the most common underlying pathologies in patients who undergo surgery for refractory epilepsy. Absence of a MRI-visible lesion necessitates additional diagnostic tests and is a predictor of poor surgical outcome.We describe a series of six patients with refractory epilepsy due to histopathologically-confirmed focal cortical dysplasia, for whom pre-surgical 7 tesla T2-weighted MRIwas acquired. In four of six patients, T2 sequences showed areas of marked superficial hypointensity, co-localizing with the epileptogenic lesion. 7 tesla T2 hypointensities overlying focal cortical dysplasia may represent leptomeningeal venous vascular abnormalities associated with the underlying dysplastic cortex. Adding T2 sequences to the MRI protocol may aid in the detection of focal cortical dysplasias.

KW - Cortical localization

KW - Epilepsy

KW - FCD

KW - Magnetic resonance imaging

KW - Susceptibility weighted

KW - Ultra-high field

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DO - 10.1684/epd.2016.0838

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SN - 1294-9361

VL - 18

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EP - 323

JO - Epileptic Disorders

JF - Epileptic Disorders

IS - 3

ER -

7 tesla T₂-weighted MRI as a tool to improve detection of focal cortical dysplasia

Abstract

Keywords

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