7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures

R Van Leeuwen; R De Vries; M R Dzoljic

7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures

R Van Leeuwen
, R De Vries
, M R Dzoljic

Infection & Immunity

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

7-Nitro indazole (25-100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system (CNS) following administration of 7-nitro indazole may be due to inhibition of neuronal NO synthase, implying that NO acts as an excitatory and proconvulsant factor in the CNS.

Original language	English
Pages (from-to)	211-3
Number of pages	3
Journal	European Journal of Pharmacology
Volume	287
Issue number	2
Publication status	Published - 12 Dec 1995

Keywords

Animals
Dose-Response Relationship, Drug
Enzyme Inhibitors
Indazoles
Male
Mice
Mice, Inbred Strains
Motor Activity
Nitric Oxide Synthase
Pilocarpine
Seizures
Journal Article

Cite this

@article{b8f7249646f24f539f09cc14cd4b6e63,

title = "7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures",

abstract = "7-Nitro indazole (25-100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system (CNS) following administration of 7-nitro indazole may be due to inhibition of neuronal NO synthase, implying that NO acts as an excitatory and proconvulsant factor in the CNS.",

keywords = "Animals, Dose-Response Relationship, Drug, Enzyme Inhibitors, Indazoles, Male, Mice, Mice, Inbred Strains, Motor Activity, Nitric Oxide Synthase, Pilocarpine, Seizures, Journal Article",

author = "\{Van Leeuwen\}, R and \{De Vries\}, R and Dzoljic, \{M R\}",

year = "1995",

month = dec,

day = "12",

language = "English",

volume = "287",

pages = "211--3",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - 7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures

AU - Van Leeuwen, R

AU - De Vries, R

AU - Dzoljic, M R

PY - 1995/12/12

Y1 - 1995/12/12

N2 - 7-Nitro indazole (25-100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system (CNS) following administration of 7-nitro indazole may be due to inhibition of neuronal NO synthase, implying that NO acts as an excitatory and proconvulsant factor in the CNS.

AB - 7-Nitro indazole (25-100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system (CNS) following administration of 7-nitro indazole may be due to inhibition of neuronal NO synthase, implying that NO acts as an excitatory and proconvulsant factor in the CNS.

KW - Animals

KW - Dose-Response Relationship, Drug

KW - Enzyme Inhibitors

KW - Indazoles

KW - Male

KW - Mice

KW - Mice, Inbred Strains

KW - Motor Activity

KW - Nitric Oxide Synthase

KW - Pilocarpine

KW - Seizures

KW - Journal Article

M3 - Article

C2 - 8749039

SN - 0014-2999

VL - 287

SP - 211

EP - 213

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2

ER -

7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures

Abstract

Keywords

Fingerprint

Cite this